Q8N0X7: Spartin {ECO:0000305}

General Information

Protein names	- Spartin {ECO:0000305} - Spastic paraplegia 20 protein - Trans-activated by hepatitis C virus core protein 1
Gene names	SPG20
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N0X7

3 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEQEPQNGEP AEIKIIREAY KKAFLFVNKG LNTDELGQKE EAKNYYKQGI GHLLRGISIS
        70         80         90        100        110        120
SKESEHTGPG WESARQMQQK MKETLQNVRT RLEILEKGLA TSLQNDLQEV PKLYPEFPPK
       130        140        150        160        170        180
DMCEKLPEPQ SFSSAPQHAE VNGNTSTPSA GAVAAPASLS LPSQSCPAEA PPAYTPQAAE
       190        200        210        220        230        240
GHYTVSYGTD SGEFSSVGEE FYRNHSQPPP LETLGLDADE LILIPNGVQI FFVNPAGEVS
       250        260        270        280        290        300
APSYPGYLRI VRFLDNSLDT VLNRPPGFLQ VCDWLYPLVP DRSPVLKCTA GAYMFPDTML
       310        320        330        340        350        360
QAAGCFVGVV LSSELPEDDR ELFEDLLRQM SDLRLQANWN RAEEENEFQI PGRTRPSSDQ
       370        380        390        400        410        420
LKEASGTDVK QLDQGNKDVR HKGKRGKRAK DTSSEEVNLS HIVPCEPVPE EKPKELPEWS
       430        440        450        460        470        480
EKVAHNILSG ASWVSWGLVK GAEITGKAIQ KGASKLRERI QPEEKPVEVS PAVTKGLYIA
       490        500        510        520        530        540
KQATGGAAKV SQFLVDGVCT VANCVGKELA PHVKKHGSKL VPESLKKDKD GKSPLDGAMV
       550        560        570        580        590        600
VAASSVQGFS TVWQGLECAA KCIVNNVSAE TVQTVRYKYG YNAGEATHHA VDSAVNVGVT
       610        620        630        640        650        660
AYNINNIGIK AMVKKTATQT GHTLLEDYQI VDNSQRENQE GAANVNVRGE KDEQTKEVKE

AKKKDK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

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Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8N0X7-1-Acetylation	MEQEPQ...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N0X7-1-Acetylation	MEQEPQ...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8N0X7-1-Acetylation	MEQEPQ...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8N0X7-191-unknown	SGEFSS...	191		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12843
Q8N0X7-360-unknown	QLKEAS...	360		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12844

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SYGTDS	190	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12843
...RPSSDQ	359	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12844
...KKKDK	666	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KKKDK	666		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KKKDK	666		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	190	GTDS.\|.SGEF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	359	SSDQ.\|.QLKE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)