Q8N6H7: ADP-ribosylation factor GTPase-activating protein 2

General Information

Protein names	- ADP-ribosylation factor GTPase-activating protein 2 - ARF GAP 2 - GTPase-activating protein ZNF289 - Zinc finger protein 289
Gene names	ARFGAP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N6H7

10 N-termini

10 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of ADP-ribosylation factor GTPase-activating protein 2 - Isoform 3 of ADP-ribosylation factor GTPase-activating protein 2

Sequence View

        10         20         30         40         50         60
MAAEPNKTEI QTLFKRLRAV PTNKACFDCG AKNPSWASIT YGVFLCIDCS GVHRSLGVHL
        70         80         90        100        110        120
SFIRSTELDS NWNWFQLRCM QVGGNANATA FFRQHGCTAN DANTKYNSRA AQMYREKIRQ
       130        140        150        160        170        180
LGSAALARHG TDLWIDNMSS AVPNHSPEKK DSDFFTEHTQ PPAWDAPATE PSGTQQPAPS
       190        200        210        220        230        240
TESSGLAQPE HGPNTDLLGT SPKASLELKS SIIGKKKPAA AKKGLGAKKG LGAQKVSSQS
       250        260        270        280        290        300
FSEIERQAQV AEKLREQQAA DAKKQAEESM VASMRLAYQE LQIDRKKEEK KLQNLEGKKR
       310        320        330        340        350        360
EQAERLGMGL VSRSSVSHSV LSEMQVIEQE TPVSAKSSRS QLDLFDDVGT FASGPPKYKD
       370        380        390        400        410        420
NPFSLGESFG SRWDTDAAWG MDRVEEKEPE VTISSIRPIS ERATNRREVE SRSSGLESSE
       430        440        450        460        470        480
ARQKFAGAKA ISSDMFFGRE VDAEYEARSR LQQLSGSSAI SSSDLFGDMD GAHGAGSVSL
       490        500        510        520
GNVLPTADIA QFKQGVKSVA GKMAVLANGV MNSLQDRYGS Y         10         20         30         40         50         60
MAAEPNKTEI QTLFKRLRAV PTNKACFDCG AKNPSWASIT YGVFLCIDCS GVHRSLGVHL
        70         80         90        100        110        120
SFIRSTELDS NWNWFQLRCM QVGGNANATA FFRQHGCTAN DANTKYNSRA AQMYREKIRQ
       130        140        150        160        170        180
LGSAALARHG TDLWIDNMSS AVPNHSPEKK DSDFFTEHTQ PPAWDAPATE PSGTQQPAPS
       190        200        210        220        230        240
TESSGLAQPE HGPNTDLLGT SPKASLELKS SIIGKKKPAA AKKGLGAKKG LGAQKVSSQS
       250        260        270        280        290        300
FSEIERQAQV AEKLREQQAA DAKKQAEESM VASMRLAYQE LQIDRKKEEK KLQNLEGKKR
       310        320        330        340        350        360
EQAERLGMGL VSRSSVSHSV LSEMQVIEQE TPVSAKSSRS QLDLFDDVGT FASGPPKYKD
       370        380        390        400        410        420
NPFSLGESFG SRWDTDAAWG MDRVEEKEPE VTISSIRPIS ERATNRREVE SRSSGLESSE
       430        440        450        460        470        480
ARQKFAGAKA ISSDMFFGRE VDAEYEARSR LQQLSGSSAI SSSDLFGDMD GAHGAGSVSL
       490        500        510        520
GNVLPTADIA QFKQGVKSVA GKMAVLANGV MNSLQDRYGS Y

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 10 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8N6H7-2-unknown	MAAEPN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N6H7-2-Acetylation	AAEPNK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N6H7-2-Acetylation	AAEPNK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8N6H7-2-Acetylation	AAEPNK...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8N6H7-80-unknown	MQVGGN...	80		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000389264
Q8N6H7-270-unknown	MVASMR...	270		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000327309
Q8N6H7-319-	SVLSEM...	319			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8N6H7-322-	SEMQVI...	322			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8N6H7-364-unknown	SLGESF...	364			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8N6H7-364-	SLGESF...	364			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8N6H7-377-unknown	AAWGMD...	377		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1324
Q8N6H7-383-unknown	RVEEKE...	383		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1325

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QPAPST	180	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435488
...KSSIIG	213	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431684
...QKVSSQ	238	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434809
...GLVSRS	313	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431939
...RWDTDA	376	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1324
...AWGMDR	382	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1325
...RREVES	410	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434433
...YEARSR	449	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437305
...MNSLQD	515	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434022
...RYGSY	521	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	376	DTDA.\|.AAWG	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CASP1_HUMAN	382	GMDR.\|.RVEE	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)