Q8N6R0: eEF1A lysine and N-terminal methyltransferase {ECO:0000303|PubMed:30143613}

General Information

Protein names	- eEF1A lysine and N-terminal methyltransferase {ECO:0000303\|PubMed:30143613} - eEF1A-KNMT {ECO:0000303\|PubMed:30143613} - Methyltransferase-like protein 13 - eEF1A lysine methyltransferase {ECO:0000303\|PubMed:30143613, ECO:0000303\|PubMed:30612740} - 2.1.1.- {ECO:0000269\|PubMed:30143613, ECO:0000269\|PubMed:30612740} - eEF1A N-terminal methyltransferase {ECO:0000303\|PubMed:30143613} - 2.1.1.- {ECO:0000269\|PubMed:30143613}
Gene names	METTL13
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N6R0

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Methyltransferase-like protein 13 - Isoform 3 of Methyltransferase-like protein 13 - Isoform 4 of Methyltransferase-like protein 13 - Isoform 5 of Methyltransferase-like protein 13 - Isoform 2 of eEF1A lysine and N-terminal methyltransferase - Isoform 3 of eEF1A lysine and N-terminal methyltransferase - Isoform 4 of eEF1A lysine and N-terminal methyltransferase - Isoform 5 of eEF1A lysine and N-terminal methyltransferase

Sequence View

        10         20         30         40         50         60
MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVIGCGNS
        70         80         90        100        110        120
ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF LKMDMTQMEF PDASFQVVLD
       130        140        150        160        170        180
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
       190        200        210        220        230        240
VRVHQVANSQ DQVLEAEPQF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE
       250        260        270        280        290        300
RLAEAVQERQ QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
       310        320        330        340        350        360
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI QAELSARVME
       370        380        390        400        410        420
LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDKRY FRRLIFLSNR
       430        440        450        460        470        480
NVVQSEARLL KDVSHKAQKK RKKDRKKQRP ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG
       490        500        510        520        530        540
LALLRNPELL LEIPLALLVV GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS
       550        560        570        580        590        600
QSDRMKVHIA DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
       610        620        630        640        650        660
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL
       670        680        690
ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV         10         20         30         40         50         60
MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVIGCGNS
        70         80         90        100        110        120
ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF LKMDMTQMEF PDASFQVVLD
       130        140        150        160        170        180
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
       190        200        210        220        230        240
VRVHQVANSQ DQVLEAEPQF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE
       250        260        270        280        290        300
RLAEAVQERQ QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
       310        320        330        340        350        360
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI QAELSARVME
       370        380        390        400        410        420
LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDKRY FRRLIFLSNR
       430        440        450        460        470        480
NVVQSEARLL KDVSHKAQKK RKKDRKKQRP ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG
       490        500        510        520        530        540
LALLRNPELL LEIPLALLVV GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS
       550        560        570        580        590        600
QSDRMKVHIA DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
       610        620        630        640        650        660
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL
       670        680        690
ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV         10         20         30         40         50         60
MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVIGCGNS
        70         80         90        100        110        120
ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF LKMDMTQMEF PDASFQVVLD
       130        140        150        160        170        180
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
       190        200        210        220        230        240
VRVHQVANSQ DQVLEAEPQF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE
       250        260        270        280        290        300
RLAEAVQERQ QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
       310        320        330        340        350        360
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI QAELSARVME
       370        380        390        400        410        420
LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDKRY FRRLIFLSNR
       430        440        450        460        470        480
NVVQSEARLL KDVSHKAQKK RKKDRKKQRP ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG
       490        500        510        520        530        540
LALLRNPELL LEIPLALLVV GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS
       550        560        570        580        590        600
QSDRMKVHIA DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
       610        620        630        640        650        660
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL
       670        680        690
ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV         10         20         30         40         50         60
MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVIGCGNS
        70         80         90        100        110        120
ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF LKMDMTQMEF PDASFQVVLD
       130        140        150        160        170        180
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
       190        200        210        220        230        240
VRVHQVANSQ DQVLEAEPQF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE
       250        260        270        280        290        300
RLAEAVQERQ QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
       310        320        330        340        350        360
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI QAELSARVME
       370        380        390        400        410        420
LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDKRY FRRLIFLSNR
       430        440        450        460        470        480
NVVQSEARLL KDVSHKAQKK RKKDRKKQRP ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG
       490        500        510        520        530        540
LALLRNPELL LEIPLALLVV GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS
       550        560        570        580        590        600
QSDRMKVHIA DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
       610        620        630        640        650        660
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL
       670        680        690
ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV         10         20         30         40         50         60
MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVIGCGNS
        70         80         90        100        110        120
ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF LKMDMTQMEF PDASFQVVLD
       130        140        150        160        170        180
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
       190        200        210        220        230        240
VRVHQVANSQ DQVLEAEPQF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE
       250        260        270        280        290        300
RLAEAVQERQ QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
       310        320        330        340        350        360
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI QAELSARVME
       370        380        390        400        410        420
LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDKRY FRRLIFLSNR
       430        440        450        460        470        480
NVVQSEARLL KDVSHKAQKK RKKDRKKQRP ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG
       490        500        510        520        530        540
LALLRNPELL LEIPLALLVV GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS
       550        560        570        580        590        600
QSDRMKVHIA DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
       610        620        630        640        650        660
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL
       670        680        690
ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV         10         20         30         40         50         60
MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVIGCGNS
        70         80         90        100        110        120
ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF LKMDMTQMEF PDASFQVVLD
       130        140        150        160        170        180
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
       190        200        210        220        230        240
VRVHQVANSQ DQVLEAEPQF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE
       250        260        270        280        290        300
RLAEAVQERQ QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
       310        320        330        340        350        360
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI QAELSARVME
       370        380        390        400        410        420
LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDKRY FRRLIFLSNR
       430        440        450        460        470        480
NVVQSEARLL KDVSHKAQKK RKKDRKKQRP ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG
       490        500        510        520        530        540
LALLRNPELL LEIPLALLVV GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS
       550        560        570        580        590        600
QSDRMKVHIA DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
       610        620        630        640        650        660
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL
       670        680        690
ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV         10         20         30         40         50         60
MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVIGCGNS
        70         80         90        100        110        120
ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF LKMDMTQMEF PDASFQVVLD
       130        140        150        160        170        180
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
       190        200        210        220        230        240
VRVHQVANSQ DQVLEAEPQF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE
       250        260        270        280        290        300
RLAEAVQERQ QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
       310        320        330        340        350        360
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI QAELSARVME
       370        380        390        400        410        420
LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDKRY FRRLIFLSNR
       430        440        450        460        470        480
NVVQSEARLL KDVSHKAQKK RKKDRKKQRP ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG
       490        500        510        520        530        540
LALLRNPELL LEIPLALLVV GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS
       550        560        570        580        590        600
QSDRMKVHIA DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
       610        620        630        640        650        660
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL
       670        680        690
ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV         10         20         30         40         50         60
MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVIGCGNS
        70         80         90        100        110        120
ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF LKMDMTQMEF PDASFQVVLD
       130        140        150        160        170        180
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHILKKA VGHFSREGWM
       190        200        210        220        230        240
VRVHQVANSQ DQVLEAEPQF SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE
       250        260        270        280        290        300
RLAEAVQERQ QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
       310        320        330        340        350        360
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI QAELSARVME
       370        380        390        400        410        420
LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI EDVQGDDKRY FRRLIFLSNR
       430        440        450        460        470        480
NVVQSEARLL KDVSHKAQKK RKKDRKKQRP ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG
       490        500        510        520        530        540
LALLRNPELL LEIPLALLVV GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS
       550        560        570        580        590        600
QSDRMKVHIA DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
       610        620        630        640        650        660
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHPEQKL
       670        680        690
ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8N6R0-1-unknown	MNLLPK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80916
Q8N6R0-1-Acetylation	MNLLPK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N6R0-1-Acetylation	MNLLPK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8N6R0-1-Acetylation	MNLLPK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8N6R0-1-Acetylation	MNLLPK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103488
Q8N6R0-87-unknown	MKECNA...	87		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80917
Q8N6R0-87-unknown	MKECNA...	87		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80919
Q8N6R0-87-unknown	MKECNA...	87		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97086
Q8N6R0-398-unknown	YVIEDV...	398		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12875
Q8N6R0-398-unknown	YVIEDV...	398		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150154
Q8N6R0-398-unknown	YVIEDV...	398		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151968

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PLSGDY	397	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12875
...PLSGDY	397	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133547
...PLSGDY	397	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135376
...YVRRIE	642	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76534
...YVRRIE	642	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93173
...YVRRIE	642	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93175
...TVKIV	699	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TVKIV	699	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76537
...TVKIV	699	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76535

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	397	SGDY.\|.YVIE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)