Q8NBA8: DTW domain-containing protein 2

General Information

Protein names	- DTW domain-containing protein 2
Gene names	DTWD2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NBA8

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MESQKEARTL QEPVARPSGA SSSQTPNDKE RREGGAVPAA AALGAEADDD SADGLWELPV
        70         80         90        100        110        120
EPAERRPECT RCSRPQKVCL CPFLPAHPLH ISTHLYIIQH PAEENKVLRT VPLLAACLPQ
       130        140        150        160        170        180
DKCKVKIGRR FSEERDPELS TVCRKSGTLI LYPGAEAANL EEFILDSPVY PSTIIIIDGT
       190        200        210        220        230        240
WSQAKDIFYK NSLFRHPKQV QLKTSISSQY VIRMQPTNRC LSTLECAAVA LSILEKNNYI
       250        260        270        280        290
QETLLRPLQA LCSFQLQHGA QIRLSKEHLL KNGLYPKPMP KNKRKLRKME LLMNSVKI

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8NBA8-1-Acetylation	MESQKE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8NBA8-1-Acetylation	MESQKE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8NBA8-1-Acetylation	MESQKE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8NBA8-49-unknown	DDSADG...	49		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12883
Q8NBA8-54-	GLWELP...	54			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8NBA8-54-	GLWELP...	54			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...GAEADD	48	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12883
	...NSVKI	298	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	48	EADD.\|.DDSA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)