Q8NCE0: tRNA-splicing endonuclease subunit Sen2

General Information

Protein names	- tRNA-splicing endonuclease subunit Sen2 - 4.6.1.16 - tRNA-intron endonuclease Sen2 - HsSen2
Gene names	TSEN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NCE0

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of tRNA-splicing endonuclease subunit Sen2 - Isoform 3 of tRNA-splicing endonuclease subunit Sen2 - Isoform 4 of tRNA-splicing endonuclease subunit Sen2 - Isoform 5 of tRNA-splicing endonuclease subunit Sen2

Sequence View

        10         20         30         40         50         60
MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL
        70         80         90        100        110        120
YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ
       130        140        150        160        170        180
DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVVNGDSGKS
       190        200        210        220        230        240
GGVGDPREPL GCLQEGSGCH PTTESFEKSV REDASPLPHV CCCKQDALIL QRGLHHEDGS
       250        260        270        280        290        300
QHIGLLHPGD RGPDHEYVLV EEAECAMSER EAAPNEELVQ RNRLICRRNP YRIFEYLQLS
       310        320        330        340        350        360
LEEAFFLVYA LGCLSIYYEK EPLTIVKLWK AFTVVQPTFR TTYMAYHYFR SKGWVPKVGL
       370        380        390        400        410        420
KYGTDLLLYR KGPPFYHASY SVIIELVDDH FEGSLRRPLS WKSLAALSRV SVNVSKELML
       430        440        450        460
CYLIKPSTMT DKEMESPECM KRIKVQEVIL SRWVSSRERS DQDDL         10         20         30         40         50         60
MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL
        70         80         90        100        110        120
YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ
       130        140        150        160        170        180
DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVVNGDSGKS
       190        200        210        220        230        240
GGVGDPREPL GCLQEGSGCH PTTESFEKSV REDASPLPHV CCCKQDALIL QRGLHHEDGS
       250        260        270        280        290        300
QHIGLLHPGD RGPDHEYVLV EEAECAMSER EAAPNEELVQ RNRLICRRNP YRIFEYLQLS
       310        320        330        340        350        360
LEEAFFLVYA LGCLSIYYEK EPLTIVKLWK AFTVVQPTFR TTYMAYHYFR SKGWVPKVGL
       370        380        390        400        410        420
KYGTDLLLYR KGPPFYHASY SVIIELVDDH FEGSLRRPLS WKSLAALSRV SVNVSKELML
       430        440        450        460
CYLIKPSTMT DKEMESPECM KRIKVQEVIL SRWVSSRERS DQDDL         10         20         30         40         50         60
MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL
        70         80         90        100        110        120
YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ
       130        140        150        160        170        180
DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVVNGDSGKS
       190        200        210        220        230        240
GGVGDPREPL GCLQEGSGCH PTTESFEKSV REDASPLPHV CCCKQDALIL QRGLHHEDGS
       250        260        270        280        290        300
QHIGLLHPGD RGPDHEYVLV EEAECAMSER EAAPNEELVQ RNRLICRRNP YRIFEYLQLS
       310        320        330        340        350        360
LEEAFFLVYA LGCLSIYYEK EPLTIVKLWK AFTVVQPTFR TTYMAYHYFR SKGWVPKVGL
       370        380        390        400        410        420
KYGTDLLLYR KGPPFYHASY SVIIELVDDH FEGSLRRPLS WKSLAALSRV SVNVSKELML
       430        440        450        460
CYLIKPSTMT DKEMESPECM KRIKVQEVIL SRWVSSRERS DQDDL         10         20         30         40         50         60
MAEAVFHAPK RKRRVYETYE SPLPIPFGQD HGPLKEFKIF RAEMINNNVI VRNAEDIEQL
        70         80         90        100        110        120
YGKGYFGKGI LSRSRPSFTI SDPKLVAKWK DMKTNMPIIT SKRYQHSVEW AAELMRRQGQ
       130        140        150        160        170        180
DESTVRRILK DYTKPLEHPP VKRNEEAQVH DKLNSGMVSN MEGTAGGERP SVVNGDSGKS
       190        200        210        220        230        240
GGVGDPREPL GCLQEGSGCH PTTESFEKSV REDASPLPHV CCCKQDALIL QRGLHHEDGS
       250        260        270        280        290        300
QHIGLLHPGD RGPDHEYVLV EEAECAMSER EAAPNEELVQ RNRLICRRNP YRIFEYLQLS
       310        320        330        340        350        360
LEEAFFLVYA LGCLSIYYEK EPLTIVKLWK AFTVVQPTFR TTYMAYHYFR SKGWVPKVGL
       370        380        390        400        410        420
KYGTDLLLYR KGPPFYHASY SVIIELVDDH FEGSLRRPLS WKSLAALSRV SVNVSKELML
       430        440        450        460
CYLIKPSTMT DKEMESPECM KRIKVQEVIL SRWVSSRERS DQDDL

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8NCE0-1-unknown	MAEAVF...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8NCE0-1-unknown	MAEAVF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89248
Q8NCE0-1-unknown	MAEAVF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89249
Q8NCE0-1-unknown	MAEAVF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89250
Q8NCE0-1-unknown	MAEAVF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89251
Q8NCE0-177-unknown	SGKSGG...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12892
Q8NCE0-177-unknown	SGKSGG...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145790
Q8NCE0-177-unknown	SGKSGG...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145791
Q8NCE0-177-unknown	SGKSGG...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145792

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VVNGDS	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12892
...VVNGDS	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129087
...VVNGDS	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129088
...VVNGDS	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129089
...DQDDL	465	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DQDDL	465	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84868
...DQDDL	465	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84867
...DQDDL	465	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84866

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	176	NGDS.\|.SGKS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)