Q8NEM2: SHC SH2 domain-binding protein 1

General Information

Protein names	- SHC SH2 domain-binding protein 1
Gene names	SHCBP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NEM2

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADGSLTGGG LEAAAMAPER MGWAVEQELA SLEKGLFQDE DSCSDCSYRD KPGSSLQSFM
        70         80         90        100        110        120
PEGKTFFPEI FQTNQLLFYE RFRAYQDYIL ADCKASEVQE FTAEFLEKVL EPSGWRAVWH
       130        140        150        160        170        180
TNVFKVLVEI TDVDFAALKA VVRLAEPYLC DSQVSTFTME CMKELLDLKE HRLPLQELWV
       190        200        210        220        230        240
VFDDSGVFDQ TALAIEHVRF FYQNIWRSWD EEEEDEYDYF VRCVEPRLRL HYDILEDRVP
       250        260        270        280        290        300
SGLIVDYHNL LSQCEESYRK FLNLRSSLSN CNSDSEQENI SMVEGLKLYS EMEQLKQKLK
       310        320        330        340        350        360
LIENPLLRYV FGYQKNSNIQ AKGVRSSGQK ITHVVSSTMM AGLLRSLLTD RLCQEPGEEE
       370        380        390        400        410        420
REIQFHSDPL SAINACFEGD TVIVCPGHYV VHGTFSIADS IELEGYGLPD DIVIEKRGKG
       430        440        450        460        470        480
DTFVDCTGAD IKISGIKFVQ HDAVEGILIV HRGKTTLENC VLQCETTGVT VRTSAEFLMK
       490        500        510        520        530        540
NSDLYGAKGA GIEIYPGSQC TLSDNGIHHC KEGILIKDFL DEHYDIPKIS MVNNIIHNNE
       550        560        570        580        590        600
GYGVVLVKPT IFSDLQENAE DGTEENKALK IQTSGEPDVA ERVDLEELIE CATGKMELCA
       610        620        630        640        650        660
RTDPSEQVEG NCEIVNELIA ASTQKGQIKK KRLSELGITQ ADDNLMSQEM FVGIVGNQFK
       670
WNGKGSFGTF LF

Isoforms

Sequence View

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Directness:

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8NEM2-2-unknown	MADGSL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8NEM2-2-Acetylation	ADGSLT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8NEM2-2-Acetylation	ADGSLT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8NEM2-2-Acetylation	ADGSLT...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q8NEM2-2-Acetylation	ADGSLT...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8NEM2-612-unknown	CEIVNE...	612		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12908

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DIVIEK	415	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460840
...QVEGNC	611	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12908
...GTFLF	672	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	611	EGNC.\|.CEIV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)