Q8NI22: Multiple coagulation factor deficiency protein 2

General Information

Protein names	- Multiple coagulation factor deficiency protein 2 - Neural stem cell-derived neuronal survival protein
Gene names	MCFD2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NI22

9 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Multiple coagulation factor deficiency protein 2 - Isoform 3 of Multiple coagulation factor deficiency protein 2

Sequence View

        10         20         30         40         50         60
MTMRSLLRTP FLCGLLWAFC APGARAEEPA ASFSQPGSMG LDKNTVHDQE HIMEHLEGVI
        70         80         90        100        110        120
NKPEAEMSPQ ELQLHYFKMH DYDGNNLLDG LELSTAITHV HKEEGSEQAP LMSEDELINI
       130        140
IDGVLRDDDK NNDGYIDYAE FAKSLQ         10         20         30         40         50         60
MTMRSLLRTP FLCGLLWAFC APGARAEEPA ASFSQPGSMG LDKNTVHDQE HIMEHLEGVI
        70         80         90        100        110        120
NKPEAEMSPQ ELQLHYFKMH DYDGNNLLDG LELSTAITHV HKEEGSEQAP LMSEDELINI
       130        140
IDGVLRDDDK NNDGYIDYAE FAKSLQ

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8NI22-27-unknown	EEPAAS...	27	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8NI22-53-unknown	MEHLEG...	53	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80619
Q8NI22-53-unknown	MEHLEG...	53	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q8NI22-53-unknown	MEHLEG...	53	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108909
Q8NI22-58-unknown	GVINKP...	58	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178115
Q8NI22-58-unknown	GVINKP...	58	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178114
Q8NI22-58-	GVINKP...	58		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8NI22-94-unknown	STAITH...	94	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164462
Q8NI22-94-unknown	STAITH...	94	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164461
Q8NI22-94-	STAITH...	94		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q8NI22-112-unknown	MSEDEL...	112	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14775
Q8NI22-112-unknown	MSEDEL...	112	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139943
Q8NI22-112-unknown	MSEDEL...	112	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142035
Q8NI22-134-unknown	GYIDYA...	134	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164459
Q8NI22-134-unknown	GYIDYA...	134	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164458
Q8NI22-134-	GYIDYA...	134		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EQAPLM	111	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14775
...EQAPLM	111	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt123048
...EQAPLM	111	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt125218
...AKSLQ	146	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AKSLQ	146	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt76237
...AKSLQ	146	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt76238
...AKSLQ	146		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...AKSLQ	146		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	111	APLM.\|.MSED	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)