Q8TBC4: NEDD8-activating enzyme E1 catalytic subunit

General Information

Protein names	- NEDD8-activating enzyme E1 catalytic subunit - 6.2.1.- - NEDD8-activating enzyme E1C - Ubiquitin-activating enzyme E1C - Ubiquitin-like modifier-activating enzyme 3 - Ubiquitin-activating enzyme 3
Gene names	UBA3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8TBC4

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADGEEPEKK RRRIEELLAE KMAVDGGCGD TGDWEGRWNH VKKFLERSGP FTHPDFEPST
        70         80         90        100        110        120
ESLQFLLDTC KVLVIGAGGL GCELLKNLAL SGFRQIHVID MDTIDVSNLN RQFLFRPKDI
       130        140        150        160        170        180
GRPKAEVAAE FLNDRVPNCN VVPHFNKIQD FNDTFYRQFH IIVCGLDSII ARRWINGMLI
       190        200        210        220        230        240
SLLNYEDGVL DPSSIVPLID GGTEGFKGNA RVILPGMTAC IECTLELYPP QVNFPMCTIA
       250        260        270        280        290        300
SMPRLPEHCI EYVRMLQWPK EQPFGEGVPL DGDDPEHIQW IFQKSLERAS QYNIRGVTYR
       310        320        330        340        350        360
LTQGVVKRII PAVASTNAVI AAVCATEVFK IATSAYIPLN NYLVFNDVDG LYTYTFEAER
       370        380        390        400        410        420
KENCPACSQL PQNIQFSPSA KLQEVLDYLT NSASLQMKSP AITATLEGKN RTLYLQSVTS
       430        440        450        460
IEERTRPNLS KTLKELGLVD GQELAVADVT TPQTVLFKLH FTS

Isoforms

- Isoform 2 of NEDD8-activating enzyme E1 catalytic subunit

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8TBC4-2-unknown	MADGEE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8TBC4-2-Acetylation	ADGEEP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8TBC4-2-Acetylation	ADGEEP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8TBC4-2-Acetylation	ADGEEP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8TBC4-2-Acetylation	ADGEEP...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q8TBC4-23-acetylation	AVDGGC...	23	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q8TBC4-23-acetylation	AVDGGC...	23	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163347

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LHFTS	463	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...LHFTS	463	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt89185

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)