Q8TBZ6: tRNA methyltransferase 10 homolog A

General Information

Protein names	- tRNA methyltransferase 10 homolog A - 2.1.1.221 {ECO:0000269\|PubMed:23042678, ECO:0000269\|PubMed:25053765} - RNA (guanine-9-)-methyltransferase domain-containing protein 2 - tRNA (guanine(9)-N(1))-methyltransferase TRMT10A
Gene names	TRMT10A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8TBZ6

4 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSEMLPAFI ETSNVDKKQG INEDQEESQK PRLGEGCEPI SKRQMKKLIK QKQWEEQREL
        70         80         90        100        110        120
RKQKRKEKRK RKKLERQCQM EPNSDGHDRK RVRRDVVHST LRLIIDCSFD HLMVLKDIKK
       130        140        150        160        170        180
LHKQIQRCYA ENRRALHPVQ FYLTSHGGQL KKNMDENDKG WVNWKDIHIK PEHYSELIKK
       190        200        210        220        230        240
EDLIYLTSDS PNILKELDES KAYVIGGLVD HNHHKGLTYK QASDYGINHA QLPLGNFVKM
       250        260        270        280        290        300
NSRKVLAVNH VFEIILEYLE TRDWQEAFFT ILPQRKGAVP TDKACESASH DNQSVRMEEG
       310        320        330
GSDSDSSEEE YSRNELDSPH EEKQDKENHT ESTVNSLPH

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8TBZ6-1-unknown	MSSEML...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8TBZ6-2-acetylation	SSEMLP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8TBZ6-5-	MLPAFI...	5			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q8TBZ6-5-	MLPAFI...	5			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8TBZ6-5-	MLPAFI...	5			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8TBZ6-5-	MLPAFI...	5			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q8TBZ6-5-	MLPAFI...	5			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8TBZ6-5-unknown	MLPAFI...	5			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KELDES	199	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000423628
...KAYVIG	205	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000397551
...NSLPH	339	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)