Q8TD30: Alanine aminotransferase 2

General Information

Protein names	- Alanine aminotransferase 2 - ALT2 - 2.6.1.2 - Glutamate pyruvate transaminase 2 - GPT 2 - Glutamic--alanine transaminase 2 - Glutamic--pyruvic transaminase 2
Gene names	GPT2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8TD30

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQRAAALVRR GCGPRTPSSW GRSQSSAAAE ASAVLKVRPE RSRRERILTL ESMNPQVKAV
        70         80         90        100        110        120
EYAVRGPIVL KAGEIELELQ RGIKKPFTEV IRANIGDAQA MGQQPITFLR QVMALCTYPN
       130        140        150        160        170        180
LLDSPSFPED AKKRARRILQ ACGGNSLGSY SASQGVNCIR EDVAAYITRR DGGVPADPDN
       190        200        210        220        230        240
IYLTTGASDG ISTILKILVS GGGKSRTGVM IPIPQYPLYS AVISELDAIQ VNYYLDEENC
       250        260        270        280        290        300
WALNVNELRR AVQEAKDHCD PKVLCIINPG NPTGQVQSRK CIEDVIHFAW EEKLFLLADE
       310        320        330        340        350        360
VYQDNVYSPD CRFHSFKKVL YEMGPEYSSN VELASFHSTS KGYMGECGYR GGYMEVINLH
       370        380        390        400        410        420
PEIKGQLVKL LSVRLCPPVS GQAAMDIVVN PPVAGEESFE QFSREKESVL GNLAKKAKLT
       430        440        450        460        470        480
EDLFNQVPGI HCNPLQGAMY AFPRIFIPAK AVEAAQAHQM APDMFYCMKL LEETGICVVP
       490        500        510        520
GSGFGQREGT YHFRMTILPP VEKLKTVLQK VKDFHINFLE KYA

Isoforms

- Isoform 2 of Alanine aminotransferase 2

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8TD30-1-unknown	MQRAAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8TD30-25-	SSAAAE...	25		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q8TD30-25-	SSAAAE...	25		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q8TD30-25-	SSAAAE...	25		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8TD30-25-	SSAAAE...	25		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8TD30-25-	SSAAAE...	25		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8TD30-25-	SSAAAE...	25		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8TD30-25-	SSAAAE...	25		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q8TD30-25-	SSAAAE...	25		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8TD30-25-unknown	SSAAAE...	25		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8TD30-26-	SAAAEA...	26		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8TD30-101-unknown	MGQQPI...	101	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66710

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LEKYA	523	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...LEKYA	523	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt62328

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)