Q8TDN6: Ribosome biogenesis protein BRX1 homolog

General Information

Protein names	- Ribosome biogenesis protein BRX1 homolog - Brix domain-containing protein 2
Gene names	BRIX1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8TDN6

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAATKRKRRG GFAVQAKKPK RNEIDAEPPA KRHATAEEVE EEERDRIPGP VCKGKWKNKE
        70         80         90        100        110        120
RILIFSSRGI NFRTRHLMQD LRMLMPHSKA DTKMDRKDKL FVINEVCEMK NCNKCIYFEA
       130        140        150        160        170        180
KKKQDLYMWL SNSPHGPSAK FLVQNIHTLA ELKMTGNCLK GSRPLLSFDP AFDELPHYAL
       190        200        210        220        230        240
LKELLIQIFS TPRYHPKSQP FVDHVFTFTI LDNRIWFRNF QIIEEDAALV EIGPRFVLNL
       250        260        270        280        290        300
IKIFQGSFGG PTLYENPHYQ SPNMHRRVIR SITAAKYREK QQVKDVQKLR KKEPKTLLPH
       310        320        330        340        350
DPTADVFVTP AEEKPIEIQW VKPEPKVDLK ARKKRIYKRQ RKMKQRMDSG KTK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8TDN6-1-unknown	MAATKR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8TDN6-9-unknown	RGGFAV...	9	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q8TDN6-271-unknown	SITAAK...	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10444

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RRVIRS	270	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10444
...SGKTK	353		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SGKTK	353		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SGKTK	353	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SGKTK	353		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SGKTK	353		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	270	VIRS.\|.SITA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)