Q8WYB5: Histone acetyltransferase KAT6B
Protein names | - Histone acetyltransferase KAT6B - 2.3.1.48 {ECO:0000269|PubMed:10497217} - Histone acetyltransferase MOZ2 - MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4 - MYST-4 - Monocytic leukemia zinc finger protein-related factor |
---|---|
Gene names | KAT6B |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q8WYB5 |
4
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MVKLANPLYT EWILEAIQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ LELSVQDGSV
70 80 90 100 110 120
LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK SAKGSRGSCN DLRNVDWNKL LRRAIEGLEE
130 140 150 160 170 180
PNGSSLKNIE KYLRSQSDLT STTNNPAFQQ RLRLGAKRAV NNGRLLKDGP QYRVNYGSLD
190 200 210 220 230 240
GKGAPQYPSA FPSSLPPVSL LPHEKDQPRA DPIPICSFCL GTKESNREKK PEELLSCADC
250 260 270 280 290 300
GSSGHPSCLK FCPELTTNVK ALRWQCIECK TCSACRVQGR NADNMLFCDS CDRGFHMECC
310 320 330 340 350 360
DPPLSRMPKG MWICQVCRPK KKGRKLLHEK AAQIKRRYAK PIGRPKNKLK QRLLSVTSDE
370 380 390 400 410 420
GSMNAFTGRG SPGRGQKTKV CTTPSSGHAA SGKDSSSRLA VTDPTRPGAT TKITTTSTYI
430 440 450 460 470 480
SASTLKVNKK TKGLIDGLTK FFTPSPDGRR SRGEIIDFSK HYRPRKKVSQ KQSCTSHVLA
490 500 510 520 530 540
TGTTQKLKPP PSSLPPPTPI SGQSPSSQKS STATSSPSPQ SSSSQCSVPS LSSLTTNSQL
550 560 570 580 590 600
KALFDGLSHI YTTQGQSRKK GHPSYAPPKR MRRKTELSST AKSKAHFFGK RDIRSRFISH
610 620 630 640 650 660
SSSSSWGMAR GSIFKAIAHF KRTTFLKKHR MLGRLKYKVT PQMGTPSPGK GSLTDGRIKP
670 680 690 700 710 720
DQDDDTEIKI NIKQESADVN VIGNKDVVTE EDLDVFKQAQ ELSWEKIECE SGVEDCGRYP
730 740 750 760 770 780
SVIEFGKYEI QTWYSSPYPQ EYARLPKLYL CEFCLKYMKS KNILLRHSKK CGWFHPPANE
790 800 810 820 830 840
IYRRKDLSVF EVDGNMSKIY CQNLCLLAKL FLDHKTLYYD VEPFLFYVLT KNDEKGCHLV
850 860 870 880 890 900
GYFSKEKLCQ QKYNVSCIMI MPQHQRQGFG RFLIDFSYLL SRREGQAGSP EKPLSDLGRL
910 920 930 940 950 960
SYLAYWKSVI LEYLYHHHER HISIKAISRA TGMCPHDIAT TLQHLHMIDK RDGRFVIIRR
970 980 990 1000 1010 1020
EKLILSHMEK LKTCSRANEL DPDSLRWTPI LISNAAVSEE EREAEKEAER LMEQASCWEK
1030 1040 1050 1060 1070 1080
EEQEILSTRA NSRQSPAKVQ SKNKYLHSPE SRPVTGERGQ LLELSKESSE EEEEEEDEEE
1090 1100 1110 1120 1130 1140
EEEEEEEEED EEEEEEEEEE EEEENIQSSP PRLTKPQSVA IKRKRPFVLK KKRGRKRRRI
1150 1160 1170 1180 1190 1200
NSSVTTETIS ETTEVLNEPF DNSDEERPMP QLEPTCEIEV EEDGRKPVLR KAFQHQPGKK
1210 1220 1230 1240 1250 1260
RQTEEEEGKD NHCFKNADPC RNNMNDDSSN LKEGSKDNPE PLKCKQVWPK GTKRGLSKWR
1270 1280 1290 1300 1310 1320
QNKERKTGFK LNLYTPPETP MEPDEQVTVE EQKETSEGKT SPSPIRIEEE VKETGEALLP
1330 1340 1350 1360 1370 1380
QEENRREETC APVSPNTSPG EKPEDDLIKP EEEEEEEEEE EEEEEEEEGE EEEGGGNVEK
1390 1400 1410 1420 1430 1440
DPDGAKSQEK EEPEISTEKE DSARLDDHEE EEEEDEEPSH NEDHDADDED DSHMESAEVE
1450 1460 1470 1480 1490 1500
KEELPRESFK EVLENQETFL DLNVQPGHSN PEVLMDCGVD LTASCNSEPK ELAGDPEAVP
1510 1520 1530 1540 1550 1560
ESDEEPPPGE QAQKQDQKNS KEVDTEFKEG NPATMEIDSE TVQAVQSLTQ ESSEQDDTFQ
1570 1580 1590 1600 1610 1620
DCAETQEACR SLQNYTRADQ SPQIATTLDD CQQSDHSSPV SSVHSHPGQS VRSVNSPSVP
1630 1640 1650 1660 1670 1680
ALENSYAQIS PDQSAISVPS LQNMETSPMM DVPSVSDHSQ QVVDSGFSDL GSIESTTENY
1690 1700 1710 1720 1730 1740
ENPSSYDSTM GGSICGNGSS QNSCSYSNLT SSSLTQSSCA VTQQMSNISG SCSMLQQTSI
1750 1760 1770 1780 1790 1800
SSPPTCSVKS PQGCVVERPP SSSQQLAQCS MAANFTPPMQ LAEIPETSNA NIGLYERMGQ
1810 1820 1830 1840 1850 1860
SDFGAGHYPQ PSATFSLAKL QQLTNTLIDH SLPYSHSAAV TSYANSASLS TPLSNTGLVQ
1870 1880 1890 1900 1910 1920
LSQSPHSVPG GPQAQATMTP PPNLTPPPMN LPPPLLQRNM AASNIGISHS QRLQTQIASK
1930 1940 1950 1960 1970 1980
GHISMRTKSA SLSPAAATHQ SQIYGRSQTV AMQGPARTLT MQRGMNMSVN LMPAPAYNVN
1990 2000 2010 2020 2030 2040
SVNMNMNTLN AMNGYSMSQP MMNSGYHSNH GYMNQTPQYP MQMQMGMMGT QPYAQQPMQT
2050 2060 2070
PPHGNMMYTA PGHHGYMNTG MSKQSLNGSY MRR
Isoforms
- Isoform 2 of Histone acetyltransferase KAT6B - Isoform 3 of Histone acetyltransferase KAT6BSequence View
10 20 30 40 50 60
MVKLANPLYT EWILEAIQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ LELSVQDGSV
70 80 90 100 110 120
LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK SAKGSRGSCN DLRNVDWNKL LRRAIEGLEE
130 140 150 160 170 180
PNGSSLKNIE KYLRSQSDLT STTNNPAFQQ RLRLGAKRAV NNGRLLKDGP QYRVNYGSLD
190 200 210 220 230 240
GKGAPQYPSA FPSSLPPVSL LPHEKDQPRA DPIPICSFCL GTKESNREKK PEELLSCADC
250 260 270 280 290 300
GSSGHPSCLK FCPELTTNVK ALRWQCIECK TCSACRVQGR NADNMLFCDS CDRGFHMECC
310 320 330 340 350 360
DPPLSRMPKG MWICQVCRPK KKGRKLLHEK AAQIKRRYAK PIGRPKNKLK QRLLSVTSDE
370 380 390 400 410 420
GSMNAFTGRG SPGRGQKTKV CTTPSSGHAA SGKDSSSRLA VTDPTRPGAT TKITTTSTYI
430 440 450 460 470 480
SASTLKVNKK TKGLIDGLTK FFTPSPDGRR SRGEIIDFSK HYRPRKKVSQ KQSCTSHVLA
490 500 510 520 530 540
TGTTQKLKPP PSSLPPPTPI SGQSPSSQKS STATSSPSPQ SSSSQCSVPS LSSLTTNSQL
550 560 570 580 590 600
KALFDGLSHI YTTQGQSRKK GHPSYAPPKR MRRKTELSST AKSKAHFFGK RDIRSRFISH
610 620 630 640 650 660
SSSSSWGMAR GSIFKAIAHF KRTTFLKKHR MLGRLKYKVT PQMGTPSPGK GSLTDGRIKP
670 680 690 700 710 720
DQDDDTEIKI NIKQESADVN VIGNKDVVTE EDLDVFKQAQ ELSWEKIECE SGVEDCGRYP
730 740 750 760 770 780
SVIEFGKYEI QTWYSSPYPQ EYARLPKLYL CEFCLKYMKS KNILLRHSKK CGWFHPPANE
790 800 810 820 830 840
IYRRKDLSVF EVDGNMSKIY CQNLCLLAKL FLDHKTLYYD VEPFLFYVLT KNDEKGCHLV
850 860 870 880 890 900
GYFSKEKLCQ QKYNVSCIMI MPQHQRQGFG RFLIDFSYLL SRREGQAGSP EKPLSDLGRL
910 920 930 940 950 960
SYLAYWKSVI LEYLYHHHER HISIKAISRA TGMCPHDIAT TLQHLHMIDK RDGRFVIIRR
970 980 990 1000 1010 1020
EKLILSHMEK LKTCSRANEL DPDSLRWTPI LISNAAVSEE EREAEKEAER LMEQASCWEK
1030 1040 1050 1060 1070 1080
EEQEILSTRA NSRQSPAKVQ SKNKYLHSPE SRPVTGERGQ LLELSKESSE EEEEEEDEEE
1090 1100 1110 1120 1130 1140
EEEEEEEEED EEEEEEEEEE EEEENIQSSP PRLTKPQSVA IKRKRPFVLK KKRGRKRRRI
1150 1160 1170 1180 1190 1200
NSSVTTETIS ETTEVLNEPF DNSDEERPMP QLEPTCEIEV EEDGRKPVLR KAFQHQPGKK
1210 1220 1230 1240 1250 1260
RQTEEEEGKD NHCFKNADPC RNNMNDDSSN LKEGSKDNPE PLKCKQVWPK GTKRGLSKWR
1270 1280 1290 1300 1310 1320
QNKERKTGFK LNLYTPPETP MEPDEQVTVE EQKETSEGKT SPSPIRIEEE VKETGEALLP
1330 1340 1350 1360 1370 1380
QEENRREETC APVSPNTSPG EKPEDDLIKP EEEEEEEEEE EEEEEEEEGE EEEGGGNVEK
1390 1400 1410 1420 1430 1440
DPDGAKSQEK EEPEISTEKE DSARLDDHEE EEEEDEEPSH NEDHDADDED DSHMESAEVE
1450 1460 1470 1480 1490 1500
KEELPRESFK EVLENQETFL DLNVQPGHSN PEVLMDCGVD LTASCNSEPK ELAGDPEAVP
1510 1520 1530 1540 1550 1560
ESDEEPPPGE QAQKQDQKNS KEVDTEFKEG NPATMEIDSE TVQAVQSLTQ ESSEQDDTFQ
1570 1580 1590 1600 1610 1620
DCAETQEACR SLQNYTRADQ SPQIATTLDD CQQSDHSSPV SSVHSHPGQS VRSVNSPSVP
1630 1640 1650 1660 1670 1680
ALENSYAQIS PDQSAISVPS LQNMETSPMM DVPSVSDHSQ QVVDSGFSDL GSIESTTENY
1690 1700 1710 1720 1730 1740
ENPSSYDSTM GGSICGNGSS QNSCSYSNLT SSSLTQSSCA VTQQMSNISG SCSMLQQTSI
1750 1760 1770 1780 1790 1800
SSPPTCSVKS PQGCVVERPP SSSQQLAQCS MAANFTPPMQ LAEIPETSNA NIGLYERMGQ
1810 1820 1830 1840 1850 1860
SDFGAGHYPQ PSATFSLAKL QQLTNTLIDH SLPYSHSAAV TSYANSASLS TPLSNTGLVQ
1870 1880 1890 1900 1910 1920
LSQSPHSVPG GPQAQATMTP PPNLTPPPMN LPPPLLQRNM AASNIGISHS QRLQTQIASK
1930 1940 1950 1960 1970 1980
GHISMRTKSA SLSPAAATHQ SQIYGRSQTV AMQGPARTLT MQRGMNMSVN LMPAPAYNVN
1990 2000 2010 2020 2030 2040
SVNMNMNTLN AMNGYSMSQP MMNSGYHSNH GYMNQTPQYP MQMQMGMMGT QPYAQQPMQT
2050 2060 2070
PPHGNMMYTA PGHHGYMNTG MSKQSLNGSY MRR
10 20 30 40 50 60
MVKLANPLYT EWILEAIQKI KKQKQRPSEE RICHAVSTSH GLDKKTVSEQ LELSVQDGSV
70 80 90 100 110 120
LKVTNKGLAS YKDPDNPGRF SSVKPGTFPK SAKGSRGSCN DLRNVDWNKL LRRAIEGLEE
130 140 150 160 170 180
PNGSSLKNIE KYLRSQSDLT STTNNPAFQQ RLRLGAKRAV NNGRLLKDGP QYRVNYGSLD
190 200 210 220 230 240
GKGAPQYPSA FPSSLPPVSL LPHEKDQPRA DPIPICSFCL GTKESNREKK PEELLSCADC
250 260 270 280 290 300
GSSGHPSCLK FCPELTTNVK ALRWQCIECK TCSACRVQGR NADNMLFCDS CDRGFHMECC
310 320 330 340 350 360
DPPLSRMPKG MWICQVCRPK KKGRKLLHEK AAQIKRRYAK PIGRPKNKLK QRLLSVTSDE
370 380 390 400 410 420
GSMNAFTGRG SPGRGQKTKV CTTPSSGHAA SGKDSSSRLA VTDPTRPGAT TKITTTSTYI
430 440 450 460 470 480
SASTLKVNKK TKGLIDGLTK FFTPSPDGRR SRGEIIDFSK HYRPRKKVSQ KQSCTSHVLA
490 500 510 520 530 540
TGTTQKLKPP PSSLPPPTPI SGQSPSSQKS STATSSPSPQ SSSSQCSVPS LSSLTTNSQL
550 560 570 580 590 600
KALFDGLSHI YTTQGQSRKK GHPSYAPPKR MRRKTELSST AKSKAHFFGK RDIRSRFISH
610 620 630 640 650 660
SSSSSWGMAR GSIFKAIAHF KRTTFLKKHR MLGRLKYKVT PQMGTPSPGK GSLTDGRIKP
670 680 690 700 710 720
DQDDDTEIKI NIKQESADVN VIGNKDVVTE EDLDVFKQAQ ELSWEKIECE SGVEDCGRYP
730 740 750 760 770 780
SVIEFGKYEI QTWYSSPYPQ EYARLPKLYL CEFCLKYMKS KNILLRHSKK CGWFHPPANE
790 800 810 820 830 840
IYRRKDLSVF EVDGNMSKIY CQNLCLLAKL FLDHKTLYYD VEPFLFYVLT KNDEKGCHLV
850 860 870 880 890 900
GYFSKEKLCQ QKYNVSCIMI MPQHQRQGFG RFLIDFSYLL SRREGQAGSP EKPLSDLGRL
910 920 930 940 950 960
SYLAYWKSVI LEYLYHHHER HISIKAISRA TGMCPHDIAT TLQHLHMIDK RDGRFVIIRR
970 980 990 1000 1010 1020
EKLILSHMEK LKTCSRANEL DPDSLRWTPI LISNAAVSEE EREAEKEAER LMEQASCWEK
1030 1040 1050 1060 1070 1080
EEQEILSTRA NSRQSPAKVQ SKNKYLHSPE SRPVTGERGQ LLELSKESSE EEEEEEDEEE
1090 1100 1110 1120 1130 1140
EEEEEEEEED EEEEEEEEEE EEEENIQSSP PRLTKPQSVA IKRKRPFVLK KKRGRKRRRI
1150 1160 1170 1180 1190 1200
NSSVTTETIS ETTEVLNEPF DNSDEERPMP QLEPTCEIEV EEDGRKPVLR KAFQHQPGKK
1210 1220 1230 1240 1250 1260
RQTEEEEGKD NHCFKNADPC RNNMNDDSSN LKEGSKDNPE PLKCKQVWPK GTKRGLSKWR
1270 1280 1290 1300 1310 1320
QNKERKTGFK LNLYTPPETP MEPDEQVTVE EQKETSEGKT SPSPIRIEEE VKETGEALLP
1330 1340 1350 1360 1370 1380
QEENRREETC APVSPNTSPG EKPEDDLIKP EEEEEEEEEE EEEEEEEEGE EEEGGGNVEK
1390 1400 1410 1420 1430 1440
DPDGAKSQEK EEPEISTEKE DSARLDDHEE EEEEDEEPSH NEDHDADDED DSHMESAEVE
1450 1460 1470 1480 1490 1500
KEELPRESFK EVLENQETFL DLNVQPGHSN PEVLMDCGVD LTASCNSEPK ELAGDPEAVP
1510 1520 1530 1540 1550 1560
ESDEEPPPGE QAQKQDQKNS KEVDTEFKEG NPATMEIDSE TVQAVQSLTQ ESSEQDDTFQ
1570 1580 1590 1600 1610 1620
DCAETQEACR SLQNYTRADQ SPQIATTLDD CQQSDHSSPV SSVHSHPGQS VRSVNSPSVP
1630 1640 1650 1660 1670 1680
ALENSYAQIS PDQSAISVPS LQNMETSPMM DVPSVSDHSQ QVVDSGFSDL GSIESTTENY
1690 1700 1710 1720 1730 1740
ENPSSYDSTM GGSICGNGSS QNSCSYSNLT SSSLTQSSCA VTQQMSNISG SCSMLQQTSI
1750 1760 1770 1780 1790 1800
SSPPTCSVKS PQGCVVERPP SSSQQLAQCS MAANFTPPMQ LAEIPETSNA NIGLYERMGQ
1810 1820 1830 1840 1850 1860
SDFGAGHYPQ PSATFSLAKL QQLTNTLIDH SLPYSHSAAV TSYANSASLS TPLSNTGLVQ
1870 1880 1890 1900 1910 1920
LSQSPHSVPG GPQAQATMTP PPNLTPPPMN LPPPLLQRNM AASNIGISHS QRLQTQIASK
1930 1940 1950 1960 1970 1980
GHISMRTKSA SLSPAAATHQ SQIYGRSQTV AMQGPARTLT MQRGMNMSVN LMPAPAYNVN
1990 2000 2010 2020 2030 2040
SVNMNMNTLN AMNGYSMSQP MMNSGYHSNH GYMNQTPQYP MQMQMGMMGT QPYAQQPMQT
2050 2060 2070
PPHGNMMYTA PGHHGYMNTG MSKQSLNGSY MRR
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q8WYB5-1-unknown | MVKLAN... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q8WYB5-1-unknown | MVKLAN... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt78588 | |||
Q8WYB5-1-unknown | MVKLAN... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt78589 | |||
Q8WYB5-1119-unknown | VAIKRK... | 1119 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12980 | |||
Q8WYB5-1119-unknown | VAIKRK... | 1119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156596 | |||
Q8WYB5-1119-unknown | VAIKRK... | 1119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157026 | |||
Q8WYB5-1602- | SVHSHP... | 1602 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q8WYB5-1602-unknown | SVHSHP... | 1602 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168651 | |||
Q8WYB5-1602-unknown | SVHSHP... | 1602 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168652 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...TKPQSV | 1118 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12980 | |||
...TKPQSV | 1118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140081 | |||
...TKPQSV | 1118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140518 | |||
...SYMRR | 2073 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SYMRR | 2073 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt74207 | |||
...SYMRR | 2073 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt74206 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 1118 | PQSV.|.VAIK | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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