Q91WR3: Activating signal cointegrator 1 complex subunit 2

General Information

Protein names	- Activating signal cointegrator 1 complex subunit 2 - ASC-1 complex subunit p100 - Trip4 complex subunit p100
Gene names	Ascc2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q91WR3

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Activating signal cointegrator 1 complex subunit 2 - Isoform 3 of Activating signal cointegrator 1 complex subunit 2

Sequence View

        10         20         30         40         50         60
MPALPLDQLQ ITHKDPKTGQ PKTSAALNPE QKADRYFVLY KPPPKDNIPA LVEEYLERAN
        70         80         90        100        110        120
FVANDLDWLL ALPHDKFWCQ VIFDETLQKC LDSYLHYVPR KFDEWVAPTP EVADMQNHLH
       130        140        150        160        170        180
RSVFLTFLRM STHKESKDHF ISPSAFGEIL YNNFLFDIPK ILDLCVLFGK GNSPLLQKMI
       190        200        210        220        230        240
GNIFTQQPSY YTDLDETIPT ILQVFSNILQ HCGLQGDGTS TTPQKLGERS PLTPSDMPLL
       250        260        270        280        290        300
ELKDIVLYLC DTSTTLWAFL DIFPLACQTF QKHDFCYRLA SFYEMAIPEL ESAIKKRRLE
       310        320        330        340        350        360
DSKLLGDMWQ RLSHSKKKLM EVFHIILNQI CLLPILESSC DNIQGFIEEF LQIFSSLLQE
       370        380        390        400        410        420
KRFLRDYDTF SPVAEDISLL QQASSALDET RTAYILQAVE SAWEGVDRQK IKDIKDPPRA
       430        440        450        460        470        480
KGSNNEVTVT AEPVSEMPSQ LENLEEDEEC MGAAAALGPA VSGVELDSLI SQVKDLLPDL
       490        500        510        520        530        540
GEGFILACLE HYSYDSEQVI NNILEDRLAP ELSQLDRGLE RQVKPDPTPL LSSRHNIFQN
       550        560        570        580        590        600
DEFDVFSRDS VDLSRVHKGR RKEENVRSLV NDKQAVVAQW QRYQKYSVVV EEVPLQPGEY
       610        620        630        640        650        660
QADDYEDEYD DTYDGNQVGA NDADSDDELI SRRPFTIPQV LRTKMPGEVQ EEEWDEEDEV
       670        680        690        700        710        720
EEEAPKPDHF IQDPAVLREK AEARRMAFLA RKGYRPENST AVTGGPRGHG QSRETTQERR
       730        740
KKEANKAARA NHNRRTMADR KRSKGMIPS         10         20         30         40         50         60
MPALPLDQLQ ITHKDPKTGQ PKTSAALNPE QKADRYFVLY KPPPKDNIPA LVEEYLERAN
        70         80         90        100        110        120
FVANDLDWLL ALPHDKFWCQ VIFDETLQKC LDSYLHYVPR KFDEWVAPTP EVADMQNHLH
       130        140        150        160        170        180
RSVFLTFLRM STHKESKDHF ISPSAFGEIL YNNFLFDIPK ILDLCVLFGK GNSPLLQKMI
       190        200        210        220        230        240
GNIFTQQPSY YTDLDETIPT ILQVFSNILQ HCGLQGDGTS TTPQKLGERS PLTPSDMPLL
       250        260        270        280        290        300
ELKDIVLYLC DTSTTLWAFL DIFPLACQTF QKHDFCYRLA SFYEMAIPEL ESAIKKRRLE
       310        320        330        340        350        360
DSKLLGDMWQ RLSHSKKKLM EVFHIILNQI CLLPILESSC DNIQGFIEEF LQIFSSLLQE
       370        380        390        400        410        420
KRFLRDYDTF SPVAEDISLL QQASSALDET RTAYILQAVE SAWEGVDRQK IKDIKDPPRA
       430        440        450        460        470        480
KGSNNEVTVT AEPVSEMPSQ LENLEEDEEC MGAAAALGPA VSGVELDSLI SQVKDLLPDL
       490        500        510        520        530        540
GEGFILACLE HYSYDSEQVI NNILEDRLAP ELSQLDRGLE RQVKPDPTPL LSSRHNIFQN
       550        560        570        580        590        600
DEFDVFSRDS VDLSRVHKGR RKEENVRSLV NDKQAVVAQW QRYQKYSVVV EEVPLQPGEY
       610        620        630        640        650        660
QADDYEDEYD DTYDGNQVGA NDADSDDELI SRRPFTIPQV LRTKMPGEVQ EEEWDEEDEV
       670        680        690        700        710        720
EEEAPKPDHF IQDPAVLREK AEARRMAFLA RKGYRPENST AVTGGPRGHG QSRETTQERR
       730        740
KKEANKAARA NHNRRTMADR KRSKGMIPS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q91WR3-1-unknown	MPALPL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q91WR3-1-unknown	MPALPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67618
Q91WR3-1-unknown	MPALPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67619
Q91WR3-615-unknown	GNQVGA...	615	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28411
Q91WR3-615-unknown	GNQVGA...	615	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154276
Q91WR3-615-unknown	GNQVGA...	615	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154846

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDTYDG	614	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28411
...DDTYDG	614	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137697
...DDTYDG	614	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138273
...GMIPS	749	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GMIPS	749	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63236

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_MOUSE	614	TYDG.\|.GNQV	inferred from experiment	unknown	MEROPS	Nunez G	Lamkanfi M et al.:Targeted peptidecentric proteom... (C14.001)	18667412,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)