Q92769: Histone deacetylase 2 {ECO:0000305}

General Information

Protein names	- Histone deacetylase 2 {ECO:0000305} - HD2 - 3.5.1.98
Gene names	HDAC2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92769

4 N-termini

10 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA
        70         80         90        100        110        120
TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA
       130        140        150        160        170        180
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH
       190        200        210        220        230        240
GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ
       250        260        270        280        290        300
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG
       310        320        330        340        350        360
GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM
       370        380        390        400        410        420
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE
       430        440        450        460        470        480
FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT

KSEQLSNP

Isoforms

- Isoform 2 of Histone deacetylase 2

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 10 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q92769-1-unknown	MAYSQG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q92769-11-unknown	KVCYYY...	11	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417026
Q92769-31-unknown	MKPHRI...	31	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430008
Q92769-31-unknown	MKPHRI...	31	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000357621
Q92769-31-unknown	MKPHRI...	31	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000427861
Q92769-31-unknown	MKPHRI...	31	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429901
Q92769-31-unknown	MKPHRI...	31	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428599
Q92769-31-unknown	MKPHRI...	31	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428653
Q92769-31-unknown	MKPHRI...	31	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429236
Q92769-31-unknown	MKPHRI...	31	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428861
Q92769-31-unknown	MKPHRI...	31	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428989
Q92769-84-unknown	NMSEYS...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13005

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RSIRPD	82	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428989
...SIRPDN	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13005
...SEYSKQ	90	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428861
...QMQRFN	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429236
...VGEDCP	101	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428653
...GEDCPV	102	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428024
...QLSTGG	116	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428599
...NRQQTD	130	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429901
...QTDMAV	133	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000427861
...QLSNP	488	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	83	RPDN.\|.NMSE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)