Q92973: Transportin-1

General Information

Protein names	- Transportin-1 - Importin beta-2 - Karyopherin beta-2 - M9 region interaction protein - MIP
Gene names	TNPO1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92973

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Transportin-1 - Isoform 3 of Transportin-1

Sequence View

        10         20         30         40         50         60
MVWDRQTKME YEWKPDEQGL QQILQLLKES QSPDTTIQRT VQQKLEQLNQ YPDFNNYLIF
        70         80         90        100        110        120
VLTKLKSEDE PTRSLSGLIL KNNVKAHFQN FPNGVTDFIK SECLNNIGDS SPLIRATVGI
       130        140        150        160        170        180
LITTIASKGE LQNWPDLLPK LCSLLDSEDY NTCEGAFGAL QKICEDSAEI LDSDVLDRPL
       190        200        210        220        230        240
NIMIPKFLQF FKHSSPKIRS HAVACVNQFI ISRTQALMLH IDSFIENLFA LAGDEEPEVR
       250        260        270        280        290        300
KNVCRALVML LEVRMDRLLP HMHNIVEYML QRTQDQDENV ALEACEFWLT LAEQPICKDV
       310        320        330        340        350        360
LVRHLPKLIP VLVNGMKYSD IDIILLKGDV EEDETIPDSE QDIRPRFHRS RTVAQQHDED
       370        380        390        400        410        420
GIEEEDDDDD EIDDDDTISD WNLRKCSAAA LDVLANVYRD ELLPHILPLL KELLFHHEWV
       430        440        450        460        470        480
VKESGILVLG AIAEGCMQGM IPYLPELIPH LIQCLSDKKA LVRSITCWTL SRYAHWVVSQ
       490        500        510        520        530        540
PPDTYLKPLM TELLKRILDS NKRVQEAACS AFATLEEEAC TELVPYLAYI LDTLVFAFSK
       550        560        570        580        590        600
YQHKNLLILY DAIGTLADSV GHHLNKPEYI QMLMPPLIQK WNMLKDEDKD LFPLLECLSS
       610        620        630        640        650        660
VATALQSGFL PYCEPVYQRC VNLVQKTLAQ AMLNNAQPDQ YEAPDKDFMI VALDLLSGLA
       670        680        690        700        710        720
EGLGGNIEQL VARSNILTLM YQCMQDKMPE VRQSSFALLG DLTKACFQHV KPCIADFMPI
       730        740        750        760        770        780
LGTNLNPEFI SVCNNATWAI GEISIQMGIE MQPYIPMVLH QLVEIINRPN TPKTLLENTA
       790        800        810        820        830        840
ITIGRLGYVC PQEVAPMLQQ FIRPWCTSLR NIRDNEEKDS AFRGICTMIS VNPSGVIQDF
       850        860        870        880        890
IFFCDAVASW INPKDDLRDM FCKILHGFKN QVGDENWRRF SDQFPLPLKE RLAAFYGV         10         20         30         40         50         60
MVWDRQTKME YEWKPDEQGL QQILQLLKES QSPDTTIQRT VQQKLEQLNQ YPDFNNYLIF
        70         80         90        100        110        120
VLTKLKSEDE PTRSLSGLIL KNNVKAHFQN FPNGVTDFIK SECLNNIGDS SPLIRATVGI
       130        140        150        160        170        180
LITTIASKGE LQNWPDLLPK LCSLLDSEDY NTCEGAFGAL QKICEDSAEI LDSDVLDRPL
       190        200        210        220        230        240
NIMIPKFLQF FKHSSPKIRS HAVACVNQFI ISRTQALMLH IDSFIENLFA LAGDEEPEVR
       250        260        270        280        290        300
KNVCRALVML LEVRMDRLLP HMHNIVEYML QRTQDQDENV ALEACEFWLT LAEQPICKDV
       310        320        330        340        350        360
LVRHLPKLIP VLVNGMKYSD IDIILLKGDV EEDETIPDSE QDIRPRFHRS RTVAQQHDED
       370        380        390        400        410        420
GIEEEDDDDD EIDDDDTISD WNLRKCSAAA LDVLANVYRD ELLPHILPLL KELLFHHEWV
       430        440        450        460        470        480
VKESGILVLG AIAEGCMQGM IPYLPELIPH LIQCLSDKKA LVRSITCWTL SRYAHWVVSQ
       490        500        510        520        530        540
PPDTYLKPLM TELLKRILDS NKRVQEAACS AFATLEEEAC TELVPYLAYI LDTLVFAFSK
       550        560        570        580        590        600
YQHKNLLILY DAIGTLADSV GHHLNKPEYI QMLMPPLIQK WNMLKDEDKD LFPLLECLSS
       610        620        630        640        650        660
VATALQSGFL PYCEPVYQRC VNLVQKTLAQ AMLNNAQPDQ YEAPDKDFMI VALDLLSGLA
       670        680        690        700        710        720
EGLGGNIEQL VARSNILTLM YQCMQDKMPE VRQSSFALLG DLTKACFQHV KPCIADFMPI
       730        740        750        760        770        780
LGTNLNPEFI SVCNNATWAI GEISIQMGIE MQPYIPMVLH QLVEIINRPN TPKTLLENTA
       790        800        810        820        830        840
ITIGRLGYVC PQEVAPMLQQ FIRPWCTSLR NIRDNEEKDS AFRGICTMIS VNPSGVIQDF
       850        860        870        880        890
IFFCDAVASW INPKDDLRDM FCKILHGFKN QVGDENWRRF SDQFPLPLKE RLAAFYGV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q92973-1-acetylation	MVWDRQ...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q92973-1-acetylation	MVWDRQ...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163354
Q92973-1-unknown	MVWDRQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92973-1-unknown	MVWDRQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92672
Q92973-9-unknown	MEYEWK...	9		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92671
Q92973-9-unknown	MEYEWK...	9		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110006
Q92973-665-unknown	GNIEQL...	665		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7994
Q92973-665-unknown	GNIEQL...	665		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154833
Q92973-665-unknown	GNIEQL...	665		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155400

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AEGLGG	664	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7994
...AEGLGG	664	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138260
...AEGLGG	664	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138835
...AFYGV	898	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AFYGV	898	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88290
...AFYGV	898	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt88289

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	664	GLGG.\|.GNIE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)