Q92994: Transcription factor IIIB 90 kDa subunit

General Information

Protein names	- Transcription factor IIIB 90 kDa subunit - TFIIIB90 - hTFIIIB90 - B-related factor 1 - BRF-1 - hBRF - TAF3B2 - TATA box-binding protein-associated factor, RNA polymerase III, subunit 2
Gene names	BRF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92994

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Transcription factor IIIB 90 kDa subunit - Isoform 3 of Transcription factor IIIB 90 kDa subunit - Isoform 4 of Transcription factor IIIB 90 kDa subunit - Isoform 5 of Transcription factor IIIB 90 kDa subunit - Isoform 6 of Transcription factor IIIB 90 kDa subunit - Isoform 7 of Transcription factor IIIB 90 kDa subunit - Isoform 8 of Transcription factor IIIB 90 kDa subunit - Isoform 9 of Transcription factor IIIB 90 kDa subunit

Sequence View

        10         20         30         40         50         60
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL
        70         80         90        100        110        120
DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR
       130        140        150        160        170        180
HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA
       190        200        210        220        230        240
IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH
       250        260        270        280        290        300
DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK
       310        320        330        340        350        360
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC
       370        380        390        400        410        420
GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS
       430        440        450        460        470        480
LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE
       490        500        510        520        530        540
YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY
       550        560        570        580        590        600
SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP
       610        620        630        640        650        660
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ
       670
MMGSNDYGCD GDEDDGY         10         20         30         40         50         60
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL
        70         80         90        100        110        120
DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR
       130        140        150        160        170        180
HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA
       190        200        210        220        230        240
IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH
       250        260        270        280        290        300
DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK
       310        320        330        340        350        360
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC
       370        380        390        400        410        420
GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS
       430        440        450        460        470        480
LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE
       490        500        510        520        530        540
YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY
       550        560        570        580        590        600
SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP
       610        620        630        640        650        660
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ
       670
MMGSNDYGCD GDEDDGY         10         20         30         40         50         60
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL
        70         80         90        100        110        120
DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR
       130        140        150        160        170        180
HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA
       190        200        210        220        230        240
IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH
       250        260        270        280        290        300
DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK
       310        320        330        340        350        360
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC
       370        380        390        400        410        420
GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS
       430        440        450        460        470        480
LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE
       490        500        510        520        530        540
YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY
       550        560        570        580        590        600
SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP
       610        620        630        640        650        660
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ
       670
MMGSNDYGCD GDEDDGY         10         20         30         40         50         60
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL
        70         80         90        100        110        120
DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR
       130        140        150        160        170        180
HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA
       190        200        210        220        230        240
IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH
       250        260        270        280        290        300
DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK
       310        320        330        340        350        360
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC
       370        380        390        400        410        420
GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS
       430        440        450        460        470        480
LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE
       490        500        510        520        530        540
YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY
       550        560        570        580        590        600
SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP
       610        620        630        640        650        660
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ
       670
MMGSNDYGCD GDEDDGY         10         20         30         40         50         60
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL
        70         80         90        100        110        120
DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR
       130        140        150        160        170        180
HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA
       190        200        210        220        230        240
IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH
       250        260        270        280        290        300
DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK
       310        320        330        340        350        360
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC
       370        380        390        400        410        420
GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS
       430        440        450        460        470        480
LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE
       490        500        510        520        530        540
YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY
       550        560        570        580        590        600
SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP
       610        620        630        640        650        660
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ
       670
MMGSNDYGCD GDEDDGY         10         20         30         40         50         60
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL
        70         80         90        100        110        120
DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR
       130        140        150        160        170        180
HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA
       190        200        210        220        230        240
IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH
       250        260        270        280        290        300
DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK
       310        320        330        340        350        360
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC
       370        380        390        400        410        420
GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS
       430        440        450        460        470        480
LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE
       490        500        510        520        530        540
YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY
       550        560        570        580        590        600
SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP
       610        620        630        640        650        660
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ
       670
MMGSNDYGCD GDEDDGY         10         20         30         40         50         60
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL
        70         80         90        100        110        120
DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR
       130        140        150        160        170        180
HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA
       190        200        210        220        230        240
IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH
       250        260        270        280        290        300
DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK
       310        320        330        340        350        360
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC
       370        380        390        400        410        420
GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS
       430        440        450        460        470        480
LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE
       490        500        510        520        530        540
YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY
       550        560        570        580        590        600
SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP
       610        620        630        640        650        660
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ
       670
MMGSNDYGCD GDEDDGY         10         20         30         40         50         60
MTGRVCRGCG GTDIELDAAR GDAVCTACGS VLEDNIIVSE VQFVESSGGG SSAVGQFVSL
        70         80         90        100        110        120
DGAGKTPTLG GGFHVNLGKE SRAQTLQNGR RHIHHLGNQL QLNQHCLDTA FNFFKMAVSR
       130        140        150        160        170        180
HLTRGRKMAH VIAACLYLVC RTEGTPHMLL DLSDLLQVNV YVLGKTFLLL ARELCINAPA
       190        200        210        220        230        240
IDPCLYIPRF AHLLEFGEKN HEVSMTALRL LQRMKRDWMH TGRRPSGLCG AALLVAARMH
       250        260        270        280        290        300
DFRRTVKEVI SVVKVCESTL RKRLTEFEDT PTSQLTIDEF MKIDLEEECD PPSYTAGQRK
       310        320        330        340        350        360
LRMKQLEQVL SKKLEEVEGE ISSYQDAIEI ELENSRPKAK GGLASLAKDG STEDTASSLC
       370        380        390        400        410        420
GEEDTEDEEL EAAASHLNKD LYRELLGGAP GSSEAAGSPE WGGRPPALGS LLDPLPTAAS
       430        440        450        460        470        480
LGISDSIREC ISSQSSDPKD ASGDGELDLS GIDDLEIDRY ILNESEARVK AELWMRENAE
       490        500        510        520        530        540
YLREQREKEA RIAKEKELGI YKEHKPKKSC KRREPIQAST AREAIEKMLE QKKISSKINY
       550        560        570        580        590        600
SVLRGLSSAG GGSPHREDAQ PEHSASARKL SRRRTPASRS GADPVTSVGK RLRPLVSTQP
       610        620        630        640        650        660
AKKVATGEAL LPSSPTLGAE PARPQAVLVE SGPVSYHADE EADEEEPDEE DGEPCVSALQ
       670
MMGSNDYGCD GDEDDGY

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q92994-1-unknown	MTGRVC...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q92994-1-unknown	MTGRVC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91929
Q92994-1-unknown	MTGRVC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91930
Q92994-1-unknown	MTGRVC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91931
Q92994-116-unknown	MAVSRH...	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91932
Q92994-116-unknown	MAVSRH...	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91933
Q92994-116-unknown	MAVSRH...	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97520
Q92994-116-unknown	MAVSRH...	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97519
Q92994-116-unknown	MAVSRH...	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97521
Q92994-205-unknown	MTALRL...	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91927
Q92994-205-unknown	MTALRL...	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91928
Q92994-205-unknown	MTALRL...	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97206
Q92994-205-unknown	MTALRL...	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97207
Q92994-205-unknown	MTALRL...	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97208
Q92994-239-unknown	MHDFRR...	239	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91934
Q92994-239-unknown	MHDFRR...	239	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97623
Q92994-239-unknown	MHDFRR...	239	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97624
Q92994-239-unknown	MHDFRR...	239	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97620
Q92994-239-unknown	MHDFRR...	239	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97621
Q92994-239-unknown	MHDFRR...	239	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97622
Q92994-580-unknown	SGADPV...	580	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10463
Q92994-580-unknown	SGADPV...	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150793
Q92994-580-unknown	SGADPV...	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151545
Q92994-580-unknown	SGADPV...	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152983
Q92994-580-unknown	SGADPV...	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153276
Q92994-580-unknown	SGADPV...	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154021

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TPASRS	579	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10463
...TPASRS	579	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134195
...TPASRS	579	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134950
...TPASRS	579	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136409
...TPASRS	579	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136700
...TPASRS	579	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137441
...EDDGY	677	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EDDGY	677	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87552
...EDDGY	677	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87546
...EDDGY	677	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87550
...EDDGY	677	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87551
...EDDGY	677	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87548

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	579	ASRS.\|.SGAD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)