Q969K3: E3 ubiquitin-protein ligase RNF34 {ECO:0000305}

General Information

Protein names	- E3 ubiquitin-protein ligase RNF34 {ECO:0000305} - 2.3.2.27 {ECO:0000269\|PubMed:25012219, ECO:0000269\|Ref.13} - Caspase regulator CARP1 {ECO:0000305} - Caspases-8 and -10-associated RING finger protein 1 {ECO:0000303\|PubMed:15069192} - CARP-1 {ECO:0000303\|PubMed:15069192} - FYVE-RING finger protein Momo {ECO:0000250\|UniProtKB:Q6AYH3} - Human RING finger homologous to inhibitor of apoptosis protein {ECO:0000303\|PubMed:12118383} - hRFI {ECO:0000303\|PubMed:12118383} - RING finger protein 34 {ECO:0000312\|HGNC:HGNC:17297} - RING finger protein RIFF {ECO:0000303\|Ref.2} - RING-type E3 ubiquitin transferase RNF34 {ECO:0000305}
Gene names	RNF34
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q969K3

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKAGATSMWA SCCGLLNEVM GTGAVRGQQS AFAGATGPFR FTPNPEFSTY PPAATEGPNI
        70         80         90        100        110        120
VCKACGLSFS VFRKKHVCCD CKKDFCSVCS VLQENLRRCS TCHLLQETAF QRPQLMRLKV
       130        140        150        160        170        180
KDLRQYLILR NIPIDTCREK EDLVDLVLCH HGLGSEDDMD TSSLNSSRSQ TSSFFTRSFF
       190        200        210        220        230        240
SNYTAPSATM SSFQGELMDG DQTSRSGVPA QVQSEITSAN TEDDDDDDDE DDDDEEENAE
       250        260        270        280        290        300
DRNPGLSKER VRASLSDLSS LDDVEGMSVR QLKEILARNF VNYSGCCEKW ELVEKVNRLY
       310        320        330        340        350        360
KENEENQKSY GERLQLQDEE DDSLCRICMD AVIDCVLLEC GHMVTCTKCG KRMSECPICR
       370
QYVVRAVHVF KS

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase RNF34

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q969K3-1-unknown	MKAGAT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q969K3-192-unknown	SFQGEL...	192	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171721
Q969K3-192-	SFQGEL...	192		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q969K3-233-unknown	DDEEEN...	233	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2290
Q969K3-233-unknown	DDEEEN...	233	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147894

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DDEDDD	232	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2290
...DDEDDD	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131254
...HVFKS	372	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HVFKS	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83618

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	232	EDDD.\|.DDEE	inferred from experiment	unknown	MEROPS	Croce CM	Sasaki S et al.:Isolation and characterization ... (C14.003)	12118383,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)