Q969R2: Oxysterol-binding protein 2

General Information

Protein names	- Oxysterol-binding protein 2 - Oxysterol-binding protein-related protein 4 - ORP-4 - OSBP-related protein 4
Gene names	OSBP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q969R2

4 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Oxysterol-binding protein 2 - Isoform 3 of Oxysterol-binding protein 2 - Isoform 4 of Oxysterol-binding protein 2 - Isoform 5 of Oxysterol-binding protein 2 - Isoform 6 of Oxysterol-binding protein 2

Sequence View

        10         20         30         40         50         60
MGKAAAPSRG GGCGGRSRGL SSLFTVVPCL SCHTAAPGMS ASTSGSGPEP KPQPQPVPEP
        70         80         90        100        110        120
ERGPLSEQVS EAVSEAVPRS EPVSETTSEP EPGAGQPSEL LQGSRPGSES SSGVGAGPFT
       130        140        150        160        170        180
KAASEPLSRA VGSATFLRPE SGSLPALKPL PLLRPGQAKT PLGVPMSGTG TTSSAPLALL
       190        200        210        220        230        240
PLDSFEGWLL KWTNYLKGYQ RRWFVLGNGL LSYYRNQGEM AHTCRGTINL STAHIDTEDS
       250        260        270        280        290        300
CGILLTSGAR SYHLKASSEV DRQQWITALE LAKAKAVRVM NTHSDDSGDD DEATTPADKS
       310        320        330        340        350        360
ELHHTLKNLS LKLDDLSTCN DLIAKHGAAL QRSLTELDGL KIPSESGEKL KVVNERATLF
       370        380        390        400        410        420
RITSNAMINA CRDFLELAEI HSRKWQRALQ YEQEQRVHLE ETIEQLAKQH NSLERAFHSA
       430        440        450        460        470        480
PGRPANPSKS FIEGSLLTPK GEDSEEDEDT EYFDAMEDST SFITVITEAK EDSRKAEGST
       490        500        510        520        530        540
GTSSVDWSSA DNVLDGASLV PKGSSKVKRR VRIPNKPNYS LNLWSIMKNC IGRELSRIPM
       550        560        570        580        590        600
PVNFNEPLSM LQRLTEDLEY HHLLDKAVHC TSSVEQMCLV AAFSVSSYST TVHRIAKPFN
       610        620        630        640        650        660
PMLGETFELD RLDDMGLRSL CEQVSHHPPS AAHYVFSKHG WSLWQEITIS SKFRGKYISI
       670        680        690        700        710        720
MPLGAIHLEF QASGNHYVWR KSTSTVHNII VGKLWIDQSG DIEIVNHKTN DRCQLKFLPY
       730        740        750        760        770        780
SYFSKEAARK VTGVVSDSQG KAHYVLSGSW DEQMECSKVM HSSPSSPSSD GKQKTVYQTL
       790        800        810        820        830        840
SAKLLWKKYP LPENAENMYY FSELALTLNE HEEGVAPTDS RLRPDQRLME KGRWDEANTE
       850        860        870        880        890        900
KQRLEEKQRL SRRRRLEACG PGSSCSSEEE KEADAYTPLW FEKRLDPLTG EMACVYKGGY
       910
WEAKEKQDWH MCPNIF         10         20         30         40         50         60
MGKAAAPSRG GGCGGRSRGL SSLFTVVPCL SCHTAAPGMS ASTSGSGPEP KPQPQPVPEP
        70         80         90        100        110        120
ERGPLSEQVS EAVSEAVPRS EPVSETTSEP EPGAGQPSEL LQGSRPGSES SSGVGAGPFT
       130        140        150        160        170        180
KAASEPLSRA VGSATFLRPE SGSLPALKPL PLLRPGQAKT PLGVPMSGTG TTSSAPLALL
       190        200        210        220        230        240
PLDSFEGWLL KWTNYLKGYQ RRWFVLGNGL LSYYRNQGEM AHTCRGTINL STAHIDTEDS
       250        260        270        280        290        300
CGILLTSGAR SYHLKASSEV DRQQWITALE LAKAKAVRVM NTHSDDSGDD DEATTPADKS
       310        320        330        340        350        360
ELHHTLKNLS LKLDDLSTCN DLIAKHGAAL QRSLTELDGL KIPSESGEKL KVVNERATLF
       370        380        390        400        410        420
RITSNAMINA CRDFLELAEI HSRKWQRALQ YEQEQRVHLE ETIEQLAKQH NSLERAFHSA
       430        440        450        460        470        480
PGRPANPSKS FIEGSLLTPK GEDSEEDEDT EYFDAMEDST SFITVITEAK EDSRKAEGST
       490        500        510        520        530        540
GTSSVDWSSA DNVLDGASLV PKGSSKVKRR VRIPNKPNYS LNLWSIMKNC IGRELSRIPM
       550        560        570        580        590        600
PVNFNEPLSM LQRLTEDLEY HHLLDKAVHC TSSVEQMCLV AAFSVSSYST TVHRIAKPFN
       610        620        630        640        650        660
PMLGETFELD RLDDMGLRSL CEQVSHHPPS AAHYVFSKHG WSLWQEITIS SKFRGKYISI
       670        680        690        700        710        720
MPLGAIHLEF QASGNHYVWR KSTSTVHNII VGKLWIDQSG DIEIVNHKTN DRCQLKFLPY
       730        740        750        760        770        780
SYFSKEAARK VTGVVSDSQG KAHYVLSGSW DEQMECSKVM HSSPSSPSSD GKQKTVYQTL
       790        800        810        820        830        840
SAKLLWKKYP LPENAENMYY FSELALTLNE HEEGVAPTDS RLRPDQRLME KGRWDEANTE
       850        860        870        880        890        900
KQRLEEKQRL SRRRRLEACG PGSSCSSEEE KEADAYTPLW FEKRLDPLTG EMACVYKGGY
       910
WEAKEKQDWH MCPNIF         10         20         30         40         50         60
MGKAAAPSRG GGCGGRSRGL SSLFTVVPCL SCHTAAPGMS ASTSGSGPEP KPQPQPVPEP
        70         80         90        100        110        120
ERGPLSEQVS EAVSEAVPRS EPVSETTSEP EPGAGQPSEL LQGSRPGSES SSGVGAGPFT
       130        140        150        160        170        180
KAASEPLSRA VGSATFLRPE SGSLPALKPL PLLRPGQAKT PLGVPMSGTG TTSSAPLALL
       190        200        210        220        230        240
PLDSFEGWLL KWTNYLKGYQ RRWFVLGNGL LSYYRNQGEM AHTCRGTINL STAHIDTEDS
       250        260        270        280        290        300
CGILLTSGAR SYHLKASSEV DRQQWITALE LAKAKAVRVM NTHSDDSGDD DEATTPADKS
       310        320        330        340        350        360
ELHHTLKNLS LKLDDLSTCN DLIAKHGAAL QRSLTELDGL KIPSESGEKL KVVNERATLF
       370        380        390        400        410        420
RITSNAMINA CRDFLELAEI HSRKWQRALQ YEQEQRVHLE ETIEQLAKQH NSLERAFHSA
       430        440        450        460        470        480
PGRPANPSKS FIEGSLLTPK GEDSEEDEDT EYFDAMEDST SFITVITEAK EDSRKAEGST
       490        500        510        520        530        540
GTSSVDWSSA DNVLDGASLV PKGSSKVKRR VRIPNKPNYS LNLWSIMKNC IGRELSRIPM
       550        560        570        580        590        600
PVNFNEPLSM LQRLTEDLEY HHLLDKAVHC TSSVEQMCLV AAFSVSSYST TVHRIAKPFN
       610        620        630        640        650        660
PMLGETFELD RLDDMGLRSL CEQVSHHPPS AAHYVFSKHG WSLWQEITIS SKFRGKYISI
       670        680        690        700        710        720
MPLGAIHLEF QASGNHYVWR KSTSTVHNII VGKLWIDQSG DIEIVNHKTN DRCQLKFLPY
       730        740        750        760        770        780
SYFSKEAARK VTGVVSDSQG KAHYVLSGSW DEQMECSKVM HSSPSSPSSD GKQKTVYQTL
       790        800        810        820        830        840
SAKLLWKKYP LPENAENMYY FSELALTLNE HEEGVAPTDS RLRPDQRLME KGRWDEANTE
       850        860        870        880        890        900
KQRLEEKQRL SRRRRLEACG PGSSCSSEEE KEADAYTPLW FEKRLDPLTG EMACVYKGGY
       910
WEAKEKQDWH MCPNIF         10         20         30         40         50         60
MGKAAAPSRG GGCGGRSRGL SSLFTVVPCL SCHTAAPGMS ASTSGSGPEP KPQPQPVPEP
        70         80         90        100        110        120
ERGPLSEQVS EAVSEAVPRS EPVSETTSEP EPGAGQPSEL LQGSRPGSES SSGVGAGPFT
       130        140        150        160        170        180
KAASEPLSRA VGSATFLRPE SGSLPALKPL PLLRPGQAKT PLGVPMSGTG TTSSAPLALL
       190        200        210        220        230        240
PLDSFEGWLL KWTNYLKGYQ RRWFVLGNGL LSYYRNQGEM AHTCRGTINL STAHIDTEDS
       250        260        270        280        290        300
CGILLTSGAR SYHLKASSEV DRQQWITALE LAKAKAVRVM NTHSDDSGDD DEATTPADKS
       310        320        330        340        350        360
ELHHTLKNLS LKLDDLSTCN DLIAKHGAAL QRSLTELDGL KIPSESGEKL KVVNERATLF
       370        380        390        400        410        420
RITSNAMINA CRDFLELAEI HSRKWQRALQ YEQEQRVHLE ETIEQLAKQH NSLERAFHSA
       430        440        450        460        470        480
PGRPANPSKS FIEGSLLTPK GEDSEEDEDT EYFDAMEDST SFITVITEAK EDSRKAEGST
       490        500        510        520        530        540
GTSSVDWSSA DNVLDGASLV PKGSSKVKRR VRIPNKPNYS LNLWSIMKNC IGRELSRIPM
       550        560        570        580        590        600
PVNFNEPLSM LQRLTEDLEY HHLLDKAVHC TSSVEQMCLV AAFSVSSYST TVHRIAKPFN
       610        620        630        640        650        660
PMLGETFELD RLDDMGLRSL CEQVSHHPPS AAHYVFSKHG WSLWQEITIS SKFRGKYISI
       670        680        690        700        710        720
MPLGAIHLEF QASGNHYVWR KSTSTVHNII VGKLWIDQSG DIEIVNHKTN DRCQLKFLPY
       730        740        750        760        770        780
SYFSKEAARK VTGVVSDSQG KAHYVLSGSW DEQMECSKVM HSSPSSPSSD GKQKTVYQTL
       790        800        810        820        830        840
SAKLLWKKYP LPENAENMYY FSELALTLNE HEEGVAPTDS RLRPDQRLME KGRWDEANTE
       850        860        870        880        890        900
KQRLEEKQRL SRRRRLEACG PGSSCSSEEE KEADAYTPLW FEKRLDPLTG EMACVYKGGY
       910
WEAKEKQDWH MCPNIF         10         20         30         40         50         60
MGKAAAPSRG GGCGGRSRGL SSLFTVVPCL SCHTAAPGMS ASTSGSGPEP KPQPQPVPEP
        70         80         90        100        110        120
ERGPLSEQVS EAVSEAVPRS EPVSETTSEP EPGAGQPSEL LQGSRPGSES SSGVGAGPFT
       130        140        150        160        170        180
KAASEPLSRA VGSATFLRPE SGSLPALKPL PLLRPGQAKT PLGVPMSGTG TTSSAPLALL
       190        200        210        220        230        240
PLDSFEGWLL KWTNYLKGYQ RRWFVLGNGL LSYYRNQGEM AHTCRGTINL STAHIDTEDS
       250        260        270        280        290        300
CGILLTSGAR SYHLKASSEV DRQQWITALE LAKAKAVRVM NTHSDDSGDD DEATTPADKS
       310        320        330        340        350        360
ELHHTLKNLS LKLDDLSTCN DLIAKHGAAL QRSLTELDGL KIPSESGEKL KVVNERATLF
       370        380        390        400        410        420
RITSNAMINA CRDFLELAEI HSRKWQRALQ YEQEQRVHLE ETIEQLAKQH NSLERAFHSA
       430        440        450        460        470        480
PGRPANPSKS FIEGSLLTPK GEDSEEDEDT EYFDAMEDST SFITVITEAK EDSRKAEGST
       490        500        510        520        530        540
GTSSVDWSSA DNVLDGASLV PKGSSKVKRR VRIPNKPNYS LNLWSIMKNC IGRELSRIPM
       550        560        570        580        590        600
PVNFNEPLSM LQRLTEDLEY HHLLDKAVHC TSSVEQMCLV AAFSVSSYST TVHRIAKPFN
       610        620        630        640        650        660
PMLGETFELD RLDDMGLRSL CEQVSHHPPS AAHYVFSKHG WSLWQEITIS SKFRGKYISI
       670        680        690        700        710        720
MPLGAIHLEF QASGNHYVWR KSTSTVHNII VGKLWIDQSG DIEIVNHKTN DRCQLKFLPY
       730        740        750        760        770        780
SYFSKEAARK VTGVVSDSQG KAHYVLSGSW DEQMECSKVM HSSPSSPSSD GKQKTVYQTL
       790        800        810        820        830        840
SAKLLWKKYP LPENAENMYY FSELALTLNE HEEGVAPTDS RLRPDQRLME KGRWDEANTE
       850        860        870        880        890        900
KQRLEEKQRL SRRRRLEACG PGSSCSSEEE KEADAYTPLW FEKRLDPLTG EMACVYKGGY
       910
WEAKEKQDWH MCPNIF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q969R2-1-unknown	MGKAAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q969R2-1-unknown	MGKAAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83871
Q969R2-40-acetylation	SASTSG...	40	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q969R2-40-acetylation	SASTSG...	40	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183180
Q969R2-367-unknown	MINACR...	367		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411497
Q969R2-367-unknown	MINACR...	367		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000385254
Q969R2-367-unknown	MINACR...	367		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000388575
Q969R2-367-unknown	MINACR...	367		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130049
Q969R2-367-unknown	MINACR...	367		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130048
Q969R2-370-unknown	ACRDFL...	370		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409838
Q969R2-370-unknown	ACRDFL...	370		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130052
Q969R2-370-unknown	ACRDFL...	370		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130051

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VMNTHS	283	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411052
...VMNTHS	283	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108869
...VMNTHS	283	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108868
...RALQYE	391	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411497
...RALQYE	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108872
...RALQYE	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108871
...CIGREL	534	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409011
...CIGREL	534	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108878
...CIGREL	534	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108877
...SRIPMP	540	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388575
...SRIPMP	540	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108875
...SRIPMP	540	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108874
...QVSHHP	627	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401776
...QVSHHP	627	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108881
...QVSHHP	627	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt108880
...CPNIF	916	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CPNIF	916	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79490
...CPNIF	916	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79489

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)