Q96BT7: Alkylated DNA repair protein alkB homolog 8

General Information

Protein names	- Alkylated DNA repair protein alkB homolog 8 - 1.14.11.- - Probable alpha-ketoglutarate-dependent dioxygenase ABH8 - S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 - tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8 - 2.1.1.229
Gene names	ALKBH8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96BT7

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Alkylated DNA repair protein alkB homolog 8 - Isoform 3 of Alkylated DNA repair protein alkB homolog 8 - Isoform 4 of Alkylated DNA repair protein alkB homolog 8

Sequence View

        10         20         30         40         50         60
MDSNHQSNYK LSKTEKKFLR KQIKAKHTLL RHEGIETVSY ATQSLVVANG GLGNGVSRNQ
        70         80         90        100        110        120
LLPVLEKCGL VDALLMPPNK PYSFARYRTT EESKRAYVTL NGKEVVDDLG QKITLYLNFV
       130        140        150        160        170        180
EKVQWKELRP QALPPGLMVV EEIISSEEEK MLLESVDWTE DTDNQNSQKS LKHRRVKHFG
       190        200        210        220        230        240
YEFHYENNNV DKDKPLSGGL PDICESFLEK WLRKGYIKHK PDQMTINQYE PGQGIPAHID
       250        260        270        280        290        300
THSAFEDEIV SLSLGSEIVM DFKHPDGIAV PVMLPRRSLL VMTGESRYLW THGITCRKFD
       310        320        330        340        350        360
TVQASESLKS GIITSDVGDL TLSKRGLRTS FTFRKVRQTP CNCSYPLVCD SQRKETPPSF
       370        380        390        400        410        420
PESDKEASRL EQEYVHQVYE EIAGHFSSTR HTPWPHIVEF LKALPSGSIV ADIGCGNGKY
       430        440        450        460        470        480
LGINKELYMI GCDRSQNLVD ICRERQFQAF VCDALAVPVR SGSCDACISI AVIHHFATAE
       490        500        510        520        530        540
RRVAALQEIV RLLRPGGKAL IYVWAMEQEY NKQKSKYLRG NRNSQGKKEE MNSDTSVQRS
       550        560        570        580        590        600
LVEQMRDMGS RDSASSVPRI NDSQEGGCNS RQVSNSKLPV HVNRTSFYSQ DVLVPWHLKG
       610        620        630        640        650        660
NPDKGKPVEP FGPIGSQDPS PVFHRYYHVF REGELEGACR TVSDVRILQS YYDQGNWCVI

LQKA         10         20         30         40         50         60
MDSNHQSNYK LSKTEKKFLR KQIKAKHTLL RHEGIETVSY ATQSLVVANG GLGNGVSRNQ
        70         80         90        100        110        120
LLPVLEKCGL VDALLMPPNK PYSFARYRTT EESKRAYVTL NGKEVVDDLG QKITLYLNFV
       130        140        150        160        170        180
EKVQWKELRP QALPPGLMVV EEIISSEEEK MLLESVDWTE DTDNQNSQKS LKHRRVKHFG
       190        200        210        220        230        240
YEFHYENNNV DKDKPLSGGL PDICESFLEK WLRKGYIKHK PDQMTINQYE PGQGIPAHID
       250        260        270        280        290        300
THSAFEDEIV SLSLGSEIVM DFKHPDGIAV PVMLPRRSLL VMTGESRYLW THGITCRKFD
       310        320        330        340        350        360
TVQASESLKS GIITSDVGDL TLSKRGLRTS FTFRKVRQTP CNCSYPLVCD SQRKETPPSF
       370        380        390        400        410        420
PESDKEASRL EQEYVHQVYE EIAGHFSSTR HTPWPHIVEF LKALPSGSIV ADIGCGNGKY
       430        440        450        460        470        480
LGINKELYMI GCDRSQNLVD ICRERQFQAF VCDALAVPVR SGSCDACISI AVIHHFATAE
       490        500        510        520        530        540
RRVAALQEIV RLLRPGGKAL IYVWAMEQEY NKQKSKYLRG NRNSQGKKEE MNSDTSVQRS
       550        560        570        580        590        600
LVEQMRDMGS RDSASSVPRI NDSQEGGCNS RQVSNSKLPV HVNRTSFYSQ DVLVPWHLKG
       610        620        630        640        650        660
NPDKGKPVEP FGPIGSQDPS PVFHRYYHVF REGELEGACR TVSDVRILQS YYDQGNWCVI

LQKA         10         20         30         40         50         60
MDSNHQSNYK LSKTEKKFLR KQIKAKHTLL RHEGIETVSY ATQSLVVANG GLGNGVSRNQ
        70         80         90        100        110        120
LLPVLEKCGL VDALLMPPNK PYSFARYRTT EESKRAYVTL NGKEVVDDLG QKITLYLNFV
       130        140        150        160        170        180
EKVQWKELRP QALPPGLMVV EEIISSEEEK MLLESVDWTE DTDNQNSQKS LKHRRVKHFG
       190        200        210        220        230        240
YEFHYENNNV DKDKPLSGGL PDICESFLEK WLRKGYIKHK PDQMTINQYE PGQGIPAHID
       250        260        270        280        290        300
THSAFEDEIV SLSLGSEIVM DFKHPDGIAV PVMLPRRSLL VMTGESRYLW THGITCRKFD
       310        320        330        340        350        360
TVQASESLKS GIITSDVGDL TLSKRGLRTS FTFRKVRQTP CNCSYPLVCD SQRKETPPSF
       370        380        390        400        410        420
PESDKEASRL EQEYVHQVYE EIAGHFSSTR HTPWPHIVEF LKALPSGSIV ADIGCGNGKY
       430        440        450        460        470        480
LGINKELYMI GCDRSQNLVD ICRERQFQAF VCDALAVPVR SGSCDACISI AVIHHFATAE
       490        500        510        520        530        540
RRVAALQEIV RLLRPGGKAL IYVWAMEQEY NKQKSKYLRG NRNSQGKKEE MNSDTSVQRS
       550        560        570        580        590        600
LVEQMRDMGS RDSASSVPRI NDSQEGGCNS RQVSNSKLPV HVNRTSFYSQ DVLVPWHLKG
       610        620        630        640        650        660
NPDKGKPVEP FGPIGSQDPS PVFHRYYHVF REGELEGACR TVSDVRILQS YYDQGNWCVI

LQKA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q96BT7-1-unknown	MDSNHQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q96BT7-1-unknown	MDSNHQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66752
Q96BT7-1-unknown	MDSNHQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66753
Q96BT7-1-unknown	MDSNHQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt96090
Q96BT7-317-unknown	VGDLTL...	317	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13050
Q96BT7-317-unknown	VGDLTL...	317	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150348

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IITSDV	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13050
...IITSDV	316	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133745
...ILQKA	664	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ILQKA	664	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62372

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	316	TSDV.\|.VGDL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)