Q96BY6: Dedicator of cytokinesis protein 10 {ECO:0000305}

General Information

Protein names	- Dedicator of cytokinesis protein 10 {ECO:0000305} - Zizimin-3
Gene names	DOCK10
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96BY6

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGERTRRFT RSLLRPGQAA ELRHSAASAA AVAVSSRQQQ RQEKPRLLEP LDYETVIEEL
        70         80         90        100        110        120
EKTYRNDPLQ DLLFFPSDDF SAATVSWDIR TLYSTVPEDA EHKAENLLVK EACKFYSSQW
       130        140        150        160        170        180
HVVNYKYEQY SGDIRQLPRA EYKPEKLPSH SFEIDHEDAD KDEDTTSHSS SKGGGGAGGT
       190        200        210        220        230        240
GVFKSGWLYK GNFNSTVNNT VTVRSFKKRY FQLTQLPDNS YIMNFYKDEK ISKEPKGCIF
       250        260        270        280        290        300
LDSCTGVVQN NRLRKYAFEL KMNDLTYFVL AAETESDMDE WIHTLNRILQ ISPEGPLQGR
       310        320        330        340        350        360
RSTELTDLGL DSLDNSVTCE CTPEETDSSE NNLHADFAKY LTETEDTVKT TRNMERLNLF
       370        380        390        400        410        420
SLDPDIDTLK LQKKDLLEPE SVIKPFEEKA AKRIMIICKA LNSNLQGCVT ENENDPITNI
       430        440        450        460        470        480
EPFFVSVALY DLRDSRKISA DFHVDLNHAA VRQMLLGASV ALENGNIDTI TPRQSEEPHI
       490        500        510        520        530        540
KGLPEEWLKF PKQAVFSVSN PHSEIVLVAK IEKVLMGNIA SGAEPYIKNP DSNKYAQKIL
       550        560        570        580        590        600
KSNRQFCSKL GKYRMPFAWA VRSVFKDNQG NVDRDSRFSP LFRQESSKIS TEDLVKLVSD
       610        620        630        640        650        660
YRRADRISKM QTIPGSLDIA VDNVPLEHPN CVTSSFIPVK PFNMMAQTEP TVEVEEFVYD
       670        680        690        700        710        720
STKYCRPYRV YKNQIYIYPK HLKYDSQKCF NKARNITVCI EFKNSDEESA KPLKCIYGKP
       730        740        750        760        770        780
GGPLFTSAAY TAVLHHSQNP DFSDEVKIEL PTQLHEKHHI LFSFYHVTCD INAKANAKKK
       790        800        810        820        830        840
EALETSVGYA WLPLMKHDQI ASQEYNIPIA TSLPPNYLSF QDSASGKHGG SDIKWVDGGK
       850        860        870        880        890        900
PLFKVSTFVV STVNTQDPHV NAFFQECQKR EKDMSQSPTS NFIRSCKNLL NVEKIHAIMS
       910        920        930        940        950        960
FLPIILNQLF KVLVQNEEDE ITTTVTRVLT DIVAKCHEEQ LDHSVQSYIK FVFKTRACKE
       970        980        990       1000       1010       1020
RTVHEELAKN VTGLLKSNDS TTVKHVLKHS WFFFAIILKS MAQHLIDTNK IQLPRPQRFP
      1030       1040       1050       1060       1070       1080
ESYQNELDNL VMVLSDHVIW KYKDALEETR RANHSVARFL KRCFTFMDRG YVFKMVNNYI
      1090       1100       1110       1120       1130       1140
SMFSSGDLKT LCQYKFDFLQ EVCQHEHFIP LCLPIRSANI PDPLTPSEST QELHASDMPE
      1150       1160       1170       1180       1190       1200
YSVTNEFCRK HFLIGILLRE VGFALQEDQD VRHLALAVLK NLMAKHSFDD RYREPRKQAQ
      1210       1220       1230       1240       1250       1260
IASLYMPLYG MLLDNMPRIY LKDLYPFTVN TSNQGSRDDL STNGGFQSQT AIKHANSVDT
      1270       1280       1290       1300       1310       1320
SFSKDVLNSI AAFSSIAIST VNHADSRASL ASLDSNPSTN EKSSEKTDNC EKIPRPLSLI
      1330       1340       1350       1360       1370       1380
GSTLRFDKLD QAETRSLLMC FLHIMKTISY ETLIAYWQRA PSPEVSDFFS ILDVCLQNFR
      1390       1400       1410       1420       1430       1440
YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS NPSCQTSGLL SQWMHSTSSH EGHKQHRSQT
      1450       1460       1470       1480       1490       1500
LPIIRGKNAL SNPKLLQMLD NTMTSNSNEI DIVHHVDTEA NIATEVCLTI LDLLSLFTQT
      1510       1520       1530       1540       1550       1560
HQRQLQQCDC QNSLMKRVFD TYMLFFQVNQ SATALKHVFA SLRLFVCKFP SAFFQGPADL
      1570       1580       1590       1600       1610       1620
CGSFCYEVLK CCNHRSRSTQ TEASALLYFF MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD
      1630       1640       1650       1660       1670       1680
AGIGGSRFQH SLAITNNFAN GDKQMKNSNF PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM
      1690       1700       1710       1720       1730       1740
LVDLQYSLAN SYASTPELRR TWLESMAKIH ARNGDLSEAA MCYIHIAALI AEYLKRKGYW
      1750       1760       1770       1780       1790       1800
KVEKICTASL LSEDTHPCDS NSLLTTPSGG SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ
      1810       1820       1830       1840       1850       1860
DTPYNENILV EQLYMCVEFL WKSERYELIA DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY
      1870       1880       1890       1900       1910       1920
LKVAEVVNSE KRLFGRYYRV AFYGQGFFEE EEGKEYIYKE PKLTGLSEIS QRLLKLYADK
      1930       1940       1950       1960       1970       1980
FGADNVKIIQ DSNKVNPKDL DPKYAYIQVT YVTPFFEEKE IEDRKTDFEM HHNINRFVFE
      1990       2000       2010       2020       2030       2040
TPFTLSGKKH GGVAEQCKRR TILTTSHLFP YVKKRIQVIS QSSTELNPIE VAIDEMSKKV
      2050       2060       2070       2080       2090       2100
SELNQLCTME EVDMIRLQLK LQGSVSVKVN AGPMAYARAF LEETNAKKYP DNQVKLLKEI
      2110       2120       2130       2140       2150       2160
FRQFADACGQ ALDVNERLIK EDQLEYQEEL RSHYKDMLSE LSTVMNEQIT GRDDLSKRGV
      2170       2180
DQTCTRVISK ATPALPTVSI SSSAEV

Isoforms

- Isoform 2 of Dedicator of cytokinesis protein 10 - Isoform 3 of Dedicator of cytokinesis protein 10

Sequence View

        10         20         30         40         50         60
MAGERTRRFT RSLLRPGQAA ELRHSAASAA AVAVSSRQQQ RQEKPRLLEP LDYETVIEEL
        70         80         90        100        110        120
EKTYRNDPLQ DLLFFPSDDF SAATVSWDIR TLYSTVPEDA EHKAENLLVK EACKFYSSQW
       130        140        150        160        170        180
HVVNYKYEQY SGDIRQLPRA EYKPEKLPSH SFEIDHEDAD KDEDTTSHSS SKGGGGAGGT
       190        200        210        220        230        240
GVFKSGWLYK GNFNSTVNNT VTVRSFKKRY FQLTQLPDNS YIMNFYKDEK ISKEPKGCIF
       250        260        270        280        290        300
LDSCTGVVQN NRLRKYAFEL KMNDLTYFVL AAETESDMDE WIHTLNRILQ ISPEGPLQGR
       310        320        330        340        350        360
RSTELTDLGL DSLDNSVTCE CTPEETDSSE NNLHADFAKY LTETEDTVKT TRNMERLNLF
       370        380        390        400        410        420
SLDPDIDTLK LQKKDLLEPE SVIKPFEEKA AKRIMIICKA LNSNLQGCVT ENENDPITNI
       430        440        450        460        470        480
EPFFVSVALY DLRDSRKISA DFHVDLNHAA VRQMLLGASV ALENGNIDTI TPRQSEEPHI
       490        500        510        520        530        540
KGLPEEWLKF PKQAVFSVSN PHSEIVLVAK IEKVLMGNIA SGAEPYIKNP DSNKYAQKIL
       550        560        570        580        590        600
KSNRQFCSKL GKYRMPFAWA VRSVFKDNQG NVDRDSRFSP LFRQESSKIS TEDLVKLVSD
       610        620        630        640        650        660
YRRADRISKM QTIPGSLDIA VDNVPLEHPN CVTSSFIPVK PFNMMAQTEP TVEVEEFVYD
       670        680        690        700        710        720
STKYCRPYRV YKNQIYIYPK HLKYDSQKCF NKARNITVCI EFKNSDEESA KPLKCIYGKP
       730        740        750        760        770        780
GGPLFTSAAY TAVLHHSQNP DFSDEVKIEL PTQLHEKHHI LFSFYHVTCD INAKANAKKK
       790        800        810        820        830        840
EALETSVGYA WLPLMKHDQI ASQEYNIPIA TSLPPNYLSF QDSASGKHGG SDIKWVDGGK
       850        860        870        880        890        900
PLFKVSTFVV STVNTQDPHV NAFFQECQKR EKDMSQSPTS NFIRSCKNLL NVEKIHAIMS
       910        920        930        940        950        960
FLPIILNQLF KVLVQNEEDE ITTTVTRVLT DIVAKCHEEQ LDHSVQSYIK FVFKTRACKE
       970        980        990       1000       1010       1020
RTVHEELAKN VTGLLKSNDS TTVKHVLKHS WFFFAIILKS MAQHLIDTNK IQLPRPQRFP
      1030       1040       1050       1060       1070       1080
ESYQNELDNL VMVLSDHVIW KYKDALEETR RANHSVARFL KRCFTFMDRG YVFKMVNNYI
      1090       1100       1110       1120       1130       1140
SMFSSGDLKT LCQYKFDFLQ EVCQHEHFIP LCLPIRSANI PDPLTPSEST QELHASDMPE
      1150       1160       1170       1180       1190       1200
YSVTNEFCRK HFLIGILLRE VGFALQEDQD VRHLALAVLK NLMAKHSFDD RYREPRKQAQ
      1210       1220       1230       1240       1250       1260
IASLYMPLYG MLLDNMPRIY LKDLYPFTVN TSNQGSRDDL STNGGFQSQT AIKHANSVDT
      1270       1280       1290       1300       1310       1320
SFSKDVLNSI AAFSSIAIST VNHADSRASL ASLDSNPSTN EKSSEKTDNC EKIPRPLSLI
      1330       1340       1350       1360       1370       1380
GSTLRFDKLD QAETRSLLMC FLHIMKTISY ETLIAYWQRA PSPEVSDFFS ILDVCLQNFR
      1390       1400       1410       1420       1430       1440
YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS NPSCQTSGLL SQWMHSTSSH EGHKQHRSQT
      1450       1460       1470       1480       1490       1500
LPIIRGKNAL SNPKLLQMLD NTMTSNSNEI DIVHHVDTEA NIATEVCLTI LDLLSLFTQT
      1510       1520       1530       1540       1550       1560
HQRQLQQCDC QNSLMKRVFD TYMLFFQVNQ SATALKHVFA SLRLFVCKFP SAFFQGPADL
      1570       1580       1590       1600       1610       1620
CGSFCYEVLK CCNHRSRSTQ TEASALLYFF MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD
      1630       1640       1650       1660       1670       1680
AGIGGSRFQH SLAITNNFAN GDKQMKNSNF PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM
      1690       1700       1710       1720       1730       1740
LVDLQYSLAN SYASTPELRR TWLESMAKIH ARNGDLSEAA MCYIHIAALI AEYLKRKGYW
      1750       1760       1770       1780       1790       1800
KVEKICTASL LSEDTHPCDS NSLLTTPSGG SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ
      1810       1820       1830       1840       1850       1860
DTPYNENILV EQLYMCVEFL WKSERYELIA DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY
      1870       1880       1890       1900       1910       1920
LKVAEVVNSE KRLFGRYYRV AFYGQGFFEE EEGKEYIYKE PKLTGLSEIS QRLLKLYADK
      1930       1940       1950       1960       1970       1980
FGADNVKIIQ DSNKVNPKDL DPKYAYIQVT YVTPFFEEKE IEDRKTDFEM HHNINRFVFE
      1990       2000       2010       2020       2030       2040
TPFTLSGKKH GGVAEQCKRR TILTTSHLFP YVKKRIQVIS QSSTELNPIE VAIDEMSKKV
      2050       2060       2070       2080       2090       2100
SELNQLCTME EVDMIRLQLK LQGSVSVKVN AGPMAYARAF LEETNAKKYP DNQVKLLKEI
      2110       2120       2130       2140       2150       2160
FRQFADACGQ ALDVNERLIK EDQLEYQEEL RSHYKDMLSE LSTVMNEQIT GRDDLSKRGV
      2170       2180
DQTCTRVISK ATPALPTVSI SSSAEV         10         20         30         40         50         60
MAGERTRRFT RSLLRPGQAA ELRHSAASAA AVAVSSRQQQ RQEKPRLLEP LDYETVIEEL
        70         80         90        100        110        120
EKTYRNDPLQ DLLFFPSDDF SAATVSWDIR TLYSTVPEDA EHKAENLLVK EACKFYSSQW
       130        140        150        160        170        180
HVVNYKYEQY SGDIRQLPRA EYKPEKLPSH SFEIDHEDAD KDEDTTSHSS SKGGGGAGGT
       190        200        210        220        230        240
GVFKSGWLYK GNFNSTVNNT VTVRSFKKRY FQLTQLPDNS YIMNFYKDEK ISKEPKGCIF
       250        260        270        280        290        300
LDSCTGVVQN NRLRKYAFEL KMNDLTYFVL AAETESDMDE WIHTLNRILQ ISPEGPLQGR
       310        320        330        340        350        360
RSTELTDLGL DSLDNSVTCE CTPEETDSSE NNLHADFAKY LTETEDTVKT TRNMERLNLF
       370        380        390        400        410        420
SLDPDIDTLK LQKKDLLEPE SVIKPFEEKA AKRIMIICKA LNSNLQGCVT ENENDPITNI
       430        440        450        460        470        480
EPFFVSVALY DLRDSRKISA DFHVDLNHAA VRQMLLGASV ALENGNIDTI TPRQSEEPHI
       490        500        510        520        530        540
KGLPEEWLKF PKQAVFSVSN PHSEIVLVAK IEKVLMGNIA SGAEPYIKNP DSNKYAQKIL
       550        560        570        580        590        600
KSNRQFCSKL GKYRMPFAWA VRSVFKDNQG NVDRDSRFSP LFRQESSKIS TEDLVKLVSD
       610        620        630        640        650        660
YRRADRISKM QTIPGSLDIA VDNVPLEHPN CVTSSFIPVK PFNMMAQTEP TVEVEEFVYD
       670        680        690        700        710        720
STKYCRPYRV YKNQIYIYPK HLKYDSQKCF NKARNITVCI EFKNSDEESA KPLKCIYGKP
       730        740        750        760        770        780
GGPLFTSAAY TAVLHHSQNP DFSDEVKIEL PTQLHEKHHI LFSFYHVTCD INAKANAKKK
       790        800        810        820        830        840
EALETSVGYA WLPLMKHDQI ASQEYNIPIA TSLPPNYLSF QDSASGKHGG SDIKWVDGGK
       850        860        870        880        890        900
PLFKVSTFVV STVNTQDPHV NAFFQECQKR EKDMSQSPTS NFIRSCKNLL NVEKIHAIMS
       910        920        930        940        950        960
FLPIILNQLF KVLVQNEEDE ITTTVTRVLT DIVAKCHEEQ LDHSVQSYIK FVFKTRACKE
       970        980        990       1000       1010       1020
RTVHEELAKN VTGLLKSNDS TTVKHVLKHS WFFFAIILKS MAQHLIDTNK IQLPRPQRFP
      1030       1040       1050       1060       1070       1080
ESYQNELDNL VMVLSDHVIW KYKDALEETR RANHSVARFL KRCFTFMDRG YVFKMVNNYI
      1090       1100       1110       1120       1130       1140
SMFSSGDLKT LCQYKFDFLQ EVCQHEHFIP LCLPIRSANI PDPLTPSEST QELHASDMPE
      1150       1160       1170       1180       1190       1200
YSVTNEFCRK HFLIGILLRE VGFALQEDQD VRHLALAVLK NLMAKHSFDD RYREPRKQAQ
      1210       1220       1230       1240       1250       1260
IASLYMPLYG MLLDNMPRIY LKDLYPFTVN TSNQGSRDDL STNGGFQSQT AIKHANSVDT
      1270       1280       1290       1300       1310       1320
SFSKDVLNSI AAFSSIAIST VNHADSRASL ASLDSNPSTN EKSSEKTDNC EKIPRPLSLI
      1330       1340       1350       1360       1370       1380
GSTLRFDKLD QAETRSLLMC FLHIMKTISY ETLIAYWQRA PSPEVSDFFS ILDVCLQNFR
      1390       1400       1410       1420       1430       1440
YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS NPSCQTSGLL SQWMHSTSSH EGHKQHRSQT
      1450       1460       1470       1480       1490       1500
LPIIRGKNAL SNPKLLQMLD NTMTSNSNEI DIVHHVDTEA NIATEVCLTI LDLLSLFTQT
      1510       1520       1530       1540       1550       1560
HQRQLQQCDC QNSLMKRVFD TYMLFFQVNQ SATALKHVFA SLRLFVCKFP SAFFQGPADL
      1570       1580       1590       1600       1610       1620
CGSFCYEVLK CCNHRSRSTQ TEASALLYFF MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD
      1630       1640       1650       1660       1670       1680
AGIGGSRFQH SLAITNNFAN GDKQMKNSNF PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM
      1690       1700       1710       1720       1730       1740
LVDLQYSLAN SYASTPELRR TWLESMAKIH ARNGDLSEAA MCYIHIAALI AEYLKRKGYW
      1750       1760       1770       1780       1790       1800
KVEKICTASL LSEDTHPCDS NSLLTTPSGG SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ
      1810       1820       1830       1840       1850       1860
DTPYNENILV EQLYMCVEFL WKSERYELIA DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY
      1870       1880       1890       1900       1910       1920
LKVAEVVNSE KRLFGRYYRV AFYGQGFFEE EEGKEYIYKE PKLTGLSEIS QRLLKLYADK
      1930       1940       1950       1960       1970       1980
FGADNVKIIQ DSNKVNPKDL DPKYAYIQVT YVTPFFEEKE IEDRKTDFEM HHNINRFVFE
      1990       2000       2010       2020       2030       2040
TPFTLSGKKH GGVAEQCKRR TILTTSHLFP YVKKRIQVIS QSSTELNPIE VAIDEMSKKV
      2050       2060       2070       2080       2090       2100
SELNQLCTME EVDMIRLQLK LQGSVSVKVN AGPMAYARAF LEETNAKKYP DNQVKLLKEI
      2110       2120       2130       2140       2150       2160
FRQFADACGQ ALDVNERLIK EDQLEYQEEL RSHYKDMLSE LSTVMNEQIT GRDDLSKRGV
      2170       2180
DQTCTRVISK ATPALPTVSI SSSAEV

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96BY6-1-unknown	MAGERT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96BY6-1-unknown	MAGERT...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73097
Q96BY6-328-	SSENNL...	328		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q96BY6-328-	SSENNL...	328		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96BY6-328-unknown	SSENNL...	328		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96BY6-328-unknown	SSENNL...	328	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161468
Q96BY6-328-unknown	SSENNL...	328	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161469

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...SSAEV	2186	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...SSAEV	2186	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt68716

TopFIND

Q96BY6: Dedicator of cytokinesis protein 10 {ECO:0000305}

General Information

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates