TopFIND 4.0

Q96D53: Atypical kinase COQ8B, mitochondrial {ECO:0000305}

General Information

Protein names
- Atypical kinase COQ8B, mitochondrial {ECO:0000305}
- 2.7.-.- {ECO:0000250|UniProtKB:Q8NI60}
- AarF domain-containing protein kinase 4 {ECO:0000312|HGNC:HGNC:19041}
- Coenzyme Q protein 8B {ECO:0000305}
Gene names ADCK4
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q96D53

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MWLKVGGLLR GTGGQLGQTV GWPCGALGPG PHRWGPCGGS WAQKFYQDGP GRGLGEEDIR 
        70         80         90        100        110        120 
RAREARPRKT PRPQLSDRSR ERKVPASRIS RLANFGGLAV GLGLGVLAEM AKKSMPGGRL 
       130        140        150        160        170        180 
QSEGGSGLDS SPFLSEANAE RIVQTLCTVR GAALKVGQML SIQDNSFISP QLQHIFERVR 
       190        200        210        220        230        240 
QSADFMPRWQ MLRVLEEELG RDWQAKVASL EEVPFAAASI GQVHQGLLRD GTEVAVKIQY 
       250        260        270        280        290        300 
PGIAQSIQSD VQNLLAVLKM SAALPAGLFA EQSLQALQQE LAWECDYRRE AACAQNFRQL 
       310        320        330        340        350        360 
LANDPFFRVP AVVKELCTTR VLGMELAGGV PLDQCQGLSQ DLRNQICFQL LTLCLRELFE 
       370        380        390        400        410        420 
FRFMQTDPNW ANFLYDASSH QVTLLDFGAS REFGTEFTDH YIEVVKAAAD GDRDCVLQKS 
       430        440        450        460        470        480 
RDLKFLTGFE TKAFSDAHVE AVMILGEPFA TQGPYDFGSG ETARRIQDLI PVLLRHRLCP 
       490        500        510        520        530        540 
PPEETYALHR KLAGAFLACA HLRAHIACRD LFQDTYHRYW ASRQPDAATA GSLPTKGDSW 
   
VDPS

Isoforms

- Isoform 2 of AarF domain-containing protein kinase 4 - Isoform 2 of Atypical kinase COQ8B, mitochondrial

Sequence View

        10         20         30         40         50         60 
MWLKVGGLLR GTGGQLGQTV GWPCGALGPG PHRWGPCGGS WAQKFYQDGP GRGLGEEDIR 
        70         80         90        100        110        120 
RAREARPRKT PRPQLSDRSR ERKVPASRIS RLANFGGLAV GLGLGVLAEM AKKSMPGGRL 
       130        140        150        160        170        180 
QSEGGSGLDS SPFLSEANAE RIVQTLCTVR GAALKVGQML SIQDNSFISP QLQHIFERVR 
       190        200        210        220        230        240 
QSADFMPRWQ MLRVLEEELG RDWQAKVASL EEVPFAAASI GQVHQGLLRD GTEVAVKIQY 
       250        260        270        280        290        300 
PGIAQSIQSD VQNLLAVLKM SAALPAGLFA EQSLQALQQE LAWECDYRRE AACAQNFRQL 
       310        320        330        340        350        360 
LANDPFFRVP AVVKELCTTR VLGMELAGGV PLDQCQGLSQ DLRNQICFQL LTLCLRELFE 
       370        380        390        400        410        420 
FRFMQTDPNW ANFLYDASSH QVTLLDFGAS REFGTEFTDH YIEVVKAAAD GDRDCVLQKS 
       430        440        450        460        470        480 
RDLKFLTGFE TKAFSDAHVE AVMILGEPFA TQGPYDFGSG ETARRIQDLI PVLLRHRLCP 
       490        500        510        520        530        540 
PPEETYALHR KLAGAFLACA HLRAHIACRD LFQDTYHRYW ASRQPDAATA GSLPTKGDSW 
   
VDPS         10         20         30         40         50         60 
MWLKVGGLLR GTGGQLGQTV GWPCGALGPG PHRWGPCGGS WAQKFYQDGP GRGLGEEDIR 
        70         80         90        100        110        120 
RAREARPRKT PRPQLSDRSR ERKVPASRIS RLANFGGLAV GLGLGVLAEM AKKSMPGGRL 
       130        140        150        160        170        180 
QSEGGSGLDS SPFLSEANAE RIVQTLCTVR GAALKVGQML SIQDNSFISP QLQHIFERVR 
       190        200        210        220        230        240 
QSADFMPRWQ MLRVLEEELG RDWQAKVASL EEVPFAAASI GQVHQGLLRD GTEVAVKIQY 
       250        260        270        280        290        300 
PGIAQSIQSD VQNLLAVLKM SAALPAGLFA EQSLQALQQE LAWECDYRRE AACAQNFRQL 
       310        320        330        340        350        360 
LANDPFFRVP AVVKELCTTR VLGMELAGGV PLDQCQGLSQ DLRNQICFQL LTLCLRELFE 
       370        380        390        400        410        420 
FRFMQTDPNW ANFLYDASSH QVTLLDFGAS REFGTEFTDH YIEVVKAAAD GDRDCVLQKS 
       430        440        450        460        470        480 
RDLKFLTGFE TKAFSDAHVE AVMILGEPFA TQGPYDFGSG ETARRIQDLI PVLLRHRLCP 
       490        500        510        520        530        540 
PPEETYALHR KLAGAFLACA HLRAHIACRD LFQDTYHRYW ASRQPDAATA GSLPTKGDSW 
   
VDPS



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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...WVDPS 544 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...WVDPS 544 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt61975

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)