Q96FV9: THO complex subunit 1

General Information

Protein names	- THO complex subunit 1 - Tho1 - Nuclear matrix protein p84 - p84N5 - hTREX84
Gene names	THOC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96FV9

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSPTPPLFSL PEARTRFTKS TREALNNKNI KPLLSTFSQV PGSENEKKCT LDQAFRGILE
        70         80         90        100        110        120
EEIINHSSCE NVLAIISLAI GGVTEGICTA STPFVLLGDV LDCLPLDQCD TIFTFVEKNV
       130        140        150        160        170        180
ATWKSNTFYS AGKNYLLRMC NDLLRRLSKS QNTVFCGRIQ LFLARLFPLS EKSGLNLQSQ
       190        200        210        220        230        240
FNLENVTVFN TNEQESTLGQ KHTEDREEGM DVEEGEMGDE EAPTTCSIPI DYNLYRKFWS
       250        260        270        280        290        300
LQDYFRNPVQ CYEKISWKTF LKYSEEVLAV FKSYKLDDTQ ASRKKMEELK TGGEHVYFAK
       310        320        330        340        350        360
FLTSEKLMDL QLSDSNFRRH ILLQYLILFQ YLKGQVKFKS SNYVLTDEQS LWIEDTTKSV
       370        380        390        400        410        420
YQLLSENPPD GERFSKMVEH ILNTEENWNS WKNEGCPSFV KERTSDTKPT RIIRKRTAPE
       430        440        450        460        470        480
DFLGKGPTKK ILMGNEELTR LWNLCPDNME ACKSETREHM PTLEEFFEEA IEQADPENMV
       490        500        510        520        530        540
ENEYKAVNNS NYGWRALRLL ARRSPHFFQP TNQQFKSLPE YLENMVIKLA KELPPPSEEI
       550        560        570        580        590        600
KTGEDEDEED NDALLKENES PDVRRDKPVT GEQIEVFANK LGEQWKILAP YLEMKDSEIR
       610        620        630        640        650
QIECDSEDMK MRAKQLLVAW QDQEGVHATP ENLINALNKS GLSDLAESLT NDNETNS

Isoforms

- Isoform 2 of THO complex subunit 1

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96FV9-1-unknown	MSPTPP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92114
Q96FV9-1-Acetylation	MSPTPP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96FV9-1-Acetylation	MSPTPP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96FV9-1-Acetylation	MSPTPP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109412
Q96FV9-2-unknown	SPTPPL...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q96FV9-2-unknown	SPTPPL...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96FV9-2-unknown	SPTPPL...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163045
Q96FV9-448-unknown	NMEACK...	448		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13060

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...NLCPDN	447	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13060
	...NETNS	657	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	447	CPDN.\|.NMEA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)