Q96JH7: Deubiquitinating protein VCIP135

General Information

Protein names	- Deubiquitinating protein VCIP135 - 3.4.19.12 - Valosin-containing protein p97/p47 complex-interacting protein 1 - Valosin-containing protein p97/p47 complex-interacting protein p135 - VCP/p47 complex-interacting 135-kDa protein
Gene names	VCPIP1
Organism	Homo sapiens
Protease Family
Protease ID	C64.006
Chromosome location
UniProt ID	Q96JH7

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSQPPPPPPP LPPPPPPPEA PQTPSSLASA AASGGLLKRR DRRILSGSCP DPKCQARLFF
        70         80         90        100        110        120
PASGSVSIEC TECGQRHEQQ QLLGVEEVTD PDVVLHNLLR NALLGVTGAP KKNTELVKVM
       130        140        150        160        170        180
GLSNYHCKLL SPILARYGMD KQTGRAKLLR DMNQGELFDC ALLGDRAFLI EPEHVNTVGY
       190        200        210        220        230        240
GKDRSGSLLY LHDTLEDIKR ANKSQECLIP VHVDGDGHCL VHAVSRALVG RELFWHALRE
       250        260        270        280        290        300
NLKQHFQQHL ARYQALFHDF IDAAEWEDII NECDPLFVPP EGVPLGLRNI HIFGLANVLH
       310        320        330        340        350        360
RPIILLDSLS GMRSSGDYSA TFLPGLIPAE KCTGKDGHLN KPICIAWSSS GRNHYIPLVG
       370        380        390        400        410        420
IKGAALPKLP MNLLPKAWGV PQDLIKKYIK LEEDGGCVIG GDRSLQDKYL LRLVAAMEEV
       430        440        450        460        470        480
FMDKHGIHPS LVADVHQYFY RRTGVIGVQP EEVTAAAKKA VMDNRLHKCL LCGALSELHV
       490        500        510        520        530        540
PPEWLAPGGK LYNLAKSTHG QLRTDKNYSF PLNNLVCSYD SVKDVLVPDY GMSNLTACNW
       550        560        570        580        590        600
CHGTSVRKVR GDGSIVYLDG DRTNSRSTGG KCGCGFKHFW DGKEYDNLPE AFPITLEWGG
       610        620        630        640        650        660
RVVRETVYWF QYESDSSLNS NVYDVAMKLV TKHFPGEFGS EILVQKVVHT ILHQTAKKNP
       670        680        690        700        710        720
DDYTPVNIDG AHAQRVGDVQ GQESESQLPT KIILTGQKTK TLHKEELNMS KTERTIQQNI
       730        740        750        760        770        780
TEQASVMQKR KTEKLKQEQK GQPRTVSPST IRDGPSSAPA TPTKAPYSPT TSKEKKIRIT
       790        800        810        820        830        840
TNDGRQSMVT LKSSTTFFEL QESIAREFNI PPYLQCIRYG FPPKELMPPQ AGMEKEPVPL
       850        860        870        880        890        900
QHGDRITIEI LKSKAEGGQS AAAHSAHTVK QEDIAVTGKL SSKELQEQAE KEMYSLCLLA
       910        920        930        940        950        960
TLMGEDVWSY AKGLPHMFQQ GGVFYSIMKK TMGMADGKHC TFPHLPGKTF VYNASEDRLE
       970        980        990       1000       1010       1020
LCVDAAGHFP IGPDVEDLVK EAVSQVRAEA TTRSRESSPS HGLLKLGSGG VVKKKSEQLH
      1030       1040       1050       1060       1070       1080
NVTAFQGKGH SLGTASGNPH LDPRARETSV VRKHNTGTDF SNSSTKTEPS VFTASSSNSE
      1090       1100       1110       1120       1130       1140
LIRIAPGVVT MRDGRQLDPD LVEAQRKKLQ EMVSSIQASM DRHLRDQSTE QSPSDLPQRK
      1150       1160       1170       1180       1190       1200
TEVVSSSAKS GSLQTGLPES FPLTGGTENL NTETTDGCVA DALGAAFATR SKAQRGNSVE
      1210       1220
ELEEMDSQDA EMTNTTEPMD HS

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96JH7-1-unknown	MSQPPP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96JH7-756-	SSAPAT...	756		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q96JH7-975-unknown	VEDLVK...	975	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13081
Q96JH7-1182-unknown	ALGAAF...	1182	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1341

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PIGPDV	974	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13081
...GCVADA	1181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1341
...PMDHS	1222	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	974	GPDV.\|.VEDL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP1_HUMAN	1181	VADA.\|.ALGA	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)