Q96MT7: Cilia- and flagella-associated protein 44 {ECO:0000312|HGNC:HGNC:25631}
| Protein names | - Cilia- and flagella-associated protein 44 {ECO:0000312|HGNC:HGNC:25631} - WD repeat-containing protein 52 {ECO:0000312|HGNC:HGNC:25631} |
|---|---|
| Gene names | WDR52 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q96MT7 |
2
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MKEPDDQDTD GEKSVTSKSD GKKSLRSSKS ESRSPVQEDN TFLEDDTDET FTKGEGSYLE
70 80 90 100 110 120
EDSDEERLEG SLSSFQYGDL QSTTVPQQTP APAVEEAEEE VKKKISESFF YDYMELASMP
130 140 150 160 170 180
FVTLDSNIPL DLLTLVHSFG YDCRKRANLQ LLDDSIAIYI AGNQLIFLNL KTKEQIYLRS
190 200 210 220 230 240
SSGEGIGVIG VHPHKTYFTV AEKGSFPDII IYEYPSLRPY RVLRDGTEKG YAYVDFNYSG
250 260 270 280 290 300
NLLASVGSNP DYTLTIWNWK EEQPILRTKA FSQEVFKVTF NPDKEEQLTT SGSGHIKFWE
310 320 330 340 350 360
MAFTFTGLKL QGSLGRFGKT ITTDIEGYME LPDGKVLSGS EWGNMLLWEG GLIKVELCRG
370 380 390 400 410 420
TSKSCHNGPI NQIMLYEGEV ITVGSDGYVR IWDFETIDTA DVIDETGLLE IEPINELQVD
430 440 450 460 470 480
KNVNLFSMIK MNETGNNFWL AQDANGAIWK LDLSFSNITQ DPECLFSFHS GAIEAVAVSP
490 500 510 520 530 540
LTYLMATTAL DCSVRIYDFA SKTPLAQMKF KQGGTALVWV PRMVNFTGAQ IIVGFEDGVV
550 560 570 580 590 600
RILELYDPKG LTIFAGRKKI LDADIQLKQV FKPHTACVTA LAYERDGEIL ATGSKDQTVF
610 620 630 640 650 660
FFEVERDYKP IGYINTPGPV CQLMWSPMSH PESTLLIICE NGYILEAPLP TIKQEEDDHD
670 680 690 700 710 720
VVSYEIKDMC IKCFHFSSVK SKILRLIEIE KRERQRELKE KIREERRNKL AAEMGEDGEK
730 740 750 760 770 780
EFQEEEEEKE EEEEEEEPLP EIFIPSTPSP ILCGFYSEPG KFWVSLGGYD SGFLYHCEFP
790 800 810 820 830 840
PCDESSDFKE QKDEPIDVRY LADTEDNPIQ TITFNINKVM MFCGMKNGAI RVYVLNQNDP
850 860 870 880 890 900
SLTSLVDYWH FNMHDNNYGC IKSIANSFDD RFLVTAGADG NIFVFNIFSE FMLRKDMKAK
910 920 930 940 950 960
VPSPRFGIET EPIPEDIEDP KAYSIENARR KREHDKLMKE VGEIKARKRE QIKALRSEFC
970 980 990 1000 1010 1020
NLLEMNEKLP KHMQFKRTDF DVDSQIRAEM HRKTAFKIQQ VEKELAWEKE KHELGLMKLK
1030 1040 1050 1060 1070 1080
NRFRDPLESD TIVVHAILSD HKISSYRLVQ PSKYSKFKRA SQSERKPSKL DRFEKEGPGR
1090 1100 1110 1120 1130 1140
KDSQRDAGGS VTIQEESIIE KGKKFRPKTL SEIIVENQIE KTRKLILKAE RAQLKIQQRK
1150 1160 1170 1180 1190 1200
KEWEELYKSK PGDDYEDPKD LQAIKEAQVY MGDFNLKTAP DYKIPEHMRI NAAKKEEELG
1210 1220 1230 1240 1250 1260
HLDSLVHGNK RHMNKCILSL RDLKVAVVEE IQCLVQELKN IQSTLHISKH IPIPKIPQIH
1270 1280 1290 1300 1310 1320
PEEVPEKRFQ YDEETLLNFK QQQMKSKDEK SPGVEQTGSG GPVGGFLKLS SRKDGDLTTR
1330 1340 1350 1360 1370 1380
DSISRSSKAS TFSLDIPKCL EFEKAEPTDV ELEIMKRDEI KHVYMQQYLV NRIKELVVTF
1390 1400 1410 1420 1430 1440
DAELRLLRHQ KLKLDTQMKL SDLHHVTLFQ EILLLKNFEK QENILQERVN SLDKEEQYMQ
1450 1460 1470 1480 1490 1500
WKINETLKEM EEKKNEITKL QEQEKALYAG FQAAIGENNK FANFLMKVLK KKIKRVKKKE
1510 1520 1530 1540 1550 1560
VEGDADEDEE SEESSEEESS LESDEDESES EDEVFDDSIC PTNCDVALFE LALHLREKRL
1570 1580 1590 1600 1610 1620
DIEEALVEEK KIVDNLKKEY DTLSKKVKIV ATNLNAAEEA LEAYQREKQQ RLNELLVVIP
1630 1640 1650 1660 1670 1680
LKLHQIEYVV FGEIPSDLSG TLVFSNHALR RLQERIHELQ EENSKQQKLN KEWRERRKQL
1690 1700 1710 1720 1730 1740
IREKREMTKT IHKMEETVRQ LMISKFGRVV NLEALQTLSV NTTLEELKIR KLRKELANAK
1750 1760 1770 1780 1790 1800
EMKMWEEKIA QMRWELMMKT KEHTRKLYQM NDLCIEKKKL DSRLNTLQNQ QGNAFQGPRE
1810 1820 1830 1840 1850
ADVVAREEVT ELIQLQAERI SALKEEIALL RRKGSLILPP IQSPREKEIQ PADL
Isoforms
- Isoform 2 of WD repeat-containing protein 52 - Isoform 1 of Cilia- and flagella-associated protein 44Sequence View
10 20 30 40 50 60
MKEPDDQDTD GEKSVTSKSD GKKSLRSSKS ESRSPVQEDN TFLEDDTDET FTKGEGSYLE
70 80 90 100 110 120
EDSDEERLEG SLSSFQYGDL QSTTVPQQTP APAVEEAEEE VKKKISESFF YDYMELASMP
130 140 150 160 170 180
FVTLDSNIPL DLLTLVHSFG YDCRKRANLQ LLDDSIAIYI AGNQLIFLNL KTKEQIYLRS
190 200 210 220 230 240
SSGEGIGVIG VHPHKTYFTV AEKGSFPDII IYEYPSLRPY RVLRDGTEKG YAYVDFNYSG
250 260 270 280 290 300
NLLASVGSNP DYTLTIWNWK EEQPILRTKA FSQEVFKVTF NPDKEEQLTT SGSGHIKFWE
310 320 330 340 350 360
MAFTFTGLKL QGSLGRFGKT ITTDIEGYME LPDGKVLSGS EWGNMLLWEG GLIKVELCRG
370 380 390 400 410 420
TSKSCHNGPI NQIMLYEGEV ITVGSDGYVR IWDFETIDTA DVIDETGLLE IEPINELQVD
430 440 450 460 470 480
KNVNLFSMIK MNETGNNFWL AQDANGAIWK LDLSFSNITQ DPECLFSFHS GAIEAVAVSP
490 500 510 520 530 540
LTYLMATTAL DCSVRIYDFA SKTPLAQMKF KQGGTALVWV PRMVNFTGAQ IIVGFEDGVV
550 560 570 580 590 600
RILELYDPKG LTIFAGRKKI LDADIQLKQV FKPHTACVTA LAYERDGEIL ATGSKDQTVF
610 620 630 640 650 660
FFEVERDYKP IGYINTPGPV CQLMWSPMSH PESTLLIICE NGYILEAPLP TIKQEEDDHD
670 680 690 700 710 720
VVSYEIKDMC IKCFHFSSVK SKILRLIEIE KRERQRELKE KIREERRNKL AAEMGEDGEK
730 740 750 760 770 780
EFQEEEEEKE EEEEEEEPLP EIFIPSTPSP ILCGFYSEPG KFWVSLGGYD SGFLYHCEFP
790 800 810 820 830 840
PCDESSDFKE QKDEPIDVRY LADTEDNPIQ TITFNINKVM MFCGMKNGAI RVYVLNQNDP
850 860 870 880 890 900
SLTSLVDYWH FNMHDNNYGC IKSIANSFDD RFLVTAGADG NIFVFNIFSE FMLRKDMKAK
910 920 930 940 950 960
VPSPRFGIET EPIPEDIEDP KAYSIENARR KREHDKLMKE VGEIKARKRE QIKALRSEFC
970 980 990 1000 1010 1020
NLLEMNEKLP KHMQFKRTDF DVDSQIRAEM HRKTAFKIQQ VEKELAWEKE KHELGLMKLK
1030 1040 1050 1060 1070 1080
NRFRDPLESD TIVVHAILSD HKISSYRLVQ PSKYSKFKRA SQSERKPSKL DRFEKEGPGR
1090 1100 1110 1120 1130 1140
KDSQRDAGGS VTIQEESIIE KGKKFRPKTL SEIIVENQIE KTRKLILKAE RAQLKIQQRK
1150 1160 1170 1180 1190 1200
KEWEELYKSK PGDDYEDPKD LQAIKEAQVY MGDFNLKTAP DYKIPEHMRI NAAKKEEELG
1210 1220 1230 1240 1250 1260
HLDSLVHGNK RHMNKCILSL RDLKVAVVEE IQCLVQELKN IQSTLHISKH IPIPKIPQIH
1270 1280 1290 1300 1310 1320
PEEVPEKRFQ YDEETLLNFK QQQMKSKDEK SPGVEQTGSG GPVGGFLKLS SRKDGDLTTR
1330 1340 1350 1360 1370 1380
DSISRSSKAS TFSLDIPKCL EFEKAEPTDV ELEIMKRDEI KHVYMQQYLV NRIKELVVTF
1390 1400 1410 1420 1430 1440
DAELRLLRHQ KLKLDTQMKL SDLHHVTLFQ EILLLKNFEK QENILQERVN SLDKEEQYMQ
1450 1460 1470 1480 1490 1500
WKINETLKEM EEKKNEITKL QEQEKALYAG FQAAIGENNK FANFLMKVLK KKIKRVKKKE
1510 1520 1530 1540 1550 1560
VEGDADEDEE SEESSEEESS LESDEDESES EDEVFDDSIC PTNCDVALFE LALHLREKRL
1570 1580 1590 1600 1610 1620
DIEEALVEEK KIVDNLKKEY DTLSKKVKIV ATNLNAAEEA LEAYQREKQQ RLNELLVVIP
1630 1640 1650 1660 1670 1680
LKLHQIEYVV FGEIPSDLSG TLVFSNHALR RLQERIHELQ EENSKQQKLN KEWRERRKQL
1690 1700 1710 1720 1730 1740
IREKREMTKT IHKMEETVRQ LMISKFGRVV NLEALQTLSV NTTLEELKIR KLRKELANAK
1750 1760 1770 1780 1790 1800
EMKMWEEKIA QMRWELMMKT KEHTRKLYQM NDLCIEKKKL DSRLNTLQNQ QGNAFQGPRE
1810 1820 1830 1840 1850
ADVVAREEVT ELIQLQAERI SALKEEIALL RRKGSLILPP IQSPREKEIQ PADL
10 20 30 40 50 60
MKEPDDQDTD GEKSVTSKSD GKKSLRSSKS ESRSPVQEDN TFLEDDTDET FTKGEGSYLE
70 80 90 100 110 120
EDSDEERLEG SLSSFQYGDL QSTTVPQQTP APAVEEAEEE VKKKISESFF YDYMELASMP
130 140 150 160 170 180
FVTLDSNIPL DLLTLVHSFG YDCRKRANLQ LLDDSIAIYI AGNQLIFLNL KTKEQIYLRS
190 200 210 220 230 240
SSGEGIGVIG VHPHKTYFTV AEKGSFPDII IYEYPSLRPY RVLRDGTEKG YAYVDFNYSG
250 260 270 280 290 300
NLLASVGSNP DYTLTIWNWK EEQPILRTKA FSQEVFKVTF NPDKEEQLTT SGSGHIKFWE
310 320 330 340 350 360
MAFTFTGLKL QGSLGRFGKT ITTDIEGYME LPDGKVLSGS EWGNMLLWEG GLIKVELCRG
370 380 390 400 410 420
TSKSCHNGPI NQIMLYEGEV ITVGSDGYVR IWDFETIDTA DVIDETGLLE IEPINELQVD
430 440 450 460 470 480
KNVNLFSMIK MNETGNNFWL AQDANGAIWK LDLSFSNITQ DPECLFSFHS GAIEAVAVSP
490 500 510 520 530 540
LTYLMATTAL DCSVRIYDFA SKTPLAQMKF KQGGTALVWV PRMVNFTGAQ IIVGFEDGVV
550 560 570 580 590 600
RILELYDPKG LTIFAGRKKI LDADIQLKQV FKPHTACVTA LAYERDGEIL ATGSKDQTVF
610 620 630 640 650 660
FFEVERDYKP IGYINTPGPV CQLMWSPMSH PESTLLIICE NGYILEAPLP TIKQEEDDHD
670 680 690 700 710 720
VVSYEIKDMC IKCFHFSSVK SKILRLIEIE KRERQRELKE KIREERRNKL AAEMGEDGEK
730 740 750 760 770 780
EFQEEEEEKE EEEEEEEPLP EIFIPSTPSP ILCGFYSEPG KFWVSLGGYD SGFLYHCEFP
790 800 810 820 830 840
PCDESSDFKE QKDEPIDVRY LADTEDNPIQ TITFNINKVM MFCGMKNGAI RVYVLNQNDP
850 860 870 880 890 900
SLTSLVDYWH FNMHDNNYGC IKSIANSFDD RFLVTAGADG NIFVFNIFSE FMLRKDMKAK
910 920 930 940 950 960
VPSPRFGIET EPIPEDIEDP KAYSIENARR KREHDKLMKE VGEIKARKRE QIKALRSEFC
970 980 990 1000 1010 1020
NLLEMNEKLP KHMQFKRTDF DVDSQIRAEM HRKTAFKIQQ VEKELAWEKE KHELGLMKLK
1030 1040 1050 1060 1070 1080
NRFRDPLESD TIVVHAILSD HKISSYRLVQ PSKYSKFKRA SQSERKPSKL DRFEKEGPGR
1090 1100 1110 1120 1130 1140
KDSQRDAGGS VTIQEESIIE KGKKFRPKTL SEIIVENQIE KTRKLILKAE RAQLKIQQRK
1150 1160 1170 1180 1190 1200
KEWEELYKSK PGDDYEDPKD LQAIKEAQVY MGDFNLKTAP DYKIPEHMRI NAAKKEEELG
1210 1220 1230 1240 1250 1260
HLDSLVHGNK RHMNKCILSL RDLKVAVVEE IQCLVQELKN IQSTLHISKH IPIPKIPQIH
1270 1280 1290 1300 1310 1320
PEEVPEKRFQ YDEETLLNFK QQQMKSKDEK SPGVEQTGSG GPVGGFLKLS SRKDGDLTTR
1330 1340 1350 1360 1370 1380
DSISRSSKAS TFSLDIPKCL EFEKAEPTDV ELEIMKRDEI KHVYMQQYLV NRIKELVVTF
1390 1400 1410 1420 1430 1440
DAELRLLRHQ KLKLDTQMKL SDLHHVTLFQ EILLLKNFEK QENILQERVN SLDKEEQYMQ
1450 1460 1470 1480 1490 1500
WKINETLKEM EEKKNEITKL QEQEKALYAG FQAAIGENNK FANFLMKVLK KKIKRVKKKE
1510 1520 1530 1540 1550 1560
VEGDADEDEE SEESSEEESS LESDEDESES EDEVFDDSIC PTNCDVALFE LALHLREKRL
1570 1580 1590 1600 1610 1620
DIEEALVEEK KIVDNLKKEY DTLSKKVKIV ATNLNAAEEA LEAYQREKQQ RLNELLVVIP
1630 1640 1650 1660 1670 1680
LKLHQIEYVV FGEIPSDLSG TLVFSNHALR RLQERIHELQ EENSKQQKLN KEWRERRKQL
1690 1700 1710 1720 1730 1740
IREKREMTKT IHKMEETVRQ LMISKFGRVV NLEALQTLSV NTTLEELKIR KLRKELANAK
1750 1760 1770 1780 1790 1800
EMKMWEEKIA QMRWELMMKT KEHTRKLYQM NDLCIEKKKL DSRLNTLQNQ QGNAFQGPRE
1810 1820 1830 1840 1850
ADVVAREEVT ELIQLQAERI SALKEEIALL RRKGSLILPP IQSPREKEIQ PADL
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q96MT7-1-unknown | MKEPDD... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q96MT7-1-unknown | MKEPDD... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt94457 | |||
| Q96MT7-687-unknown | IEIEKR... | 687 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13089 | |||
| Q96MT7-687-unknown | IEIEKR... | 687 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155727 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...KILRLI | 686 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13089 | |||
| ...KILRLI | 686 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt139173 | |||
| ...TDFDVD | 982 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| GRAB_HUMAN | 686 | LRLI.|.IEIE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|