Q96N21: AP-4 complex accessory subunit Tepsin {ECO:0000305}

General Information

Protein names	- AP-4 complex accessory subunit Tepsin {ECO:0000305} - ENTH domain-containing protein 2 {ECO:0000312\|HGNC:HGNC:26458} - Epsin for AP-4 - Tetra-epsin {ECO:0000303\|PubMed:22472443}
Gene names	ENTHD2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96N21

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAPPLRDR LSFLHRLPIL LKGTSDDDVP CPGYLFEEIA KISHESPGSS QCLLEYLLSR
        70         80         90        100        110        120
LHSSSGHGKL KVLKILLYLC SHGSSFFLLI LKRNSAFIQE AAAFAGPPDP LHGNSLYQKV
       130        140        150        160        170        180
RAAAQDLGST LFSDTVLPLA PSQPLGTPPA TGMGSQARPH STLQGFGYSK EHGRTAVRHQ
       190        200        210        220        230        240
PGQAGGGWDE LDSGPSSQNS SQNSDLSRVS DSGSHSGSDS HSGASREPGD LAERVEVVAL
       250        260        270        280        290        300
SDCQQELSLV RTVTRGPRAF LSREEAQHFI KACGLLNCEA VLQLLTCHLR GTSECTQLRA
       310        320        330        340        350        360
LCAIASLGSS DLLPQEHILL RTRPWLQELS MGSPGPVTNK ATKILRHFEA SCGQLSPARG
       370        380        390        400        410        420
TSAEPGPTAA LPGPSDLLTD AVPLPGSQVF LQPLSSTPVS SRSPAPSSGM PSSPVPTPPP
       430        440        450        460        470        480
DASPIPAPGD PSEAEARLAE SRRWRPERIP GGTDSPKRGP SSCAWSRDSL FAGMELVACP
       490        500        510        520
RLVGAGAAAG ESCPDAPRAP QTSSQRTAAK EPPGSEPSAF AFLNA

Isoforms

- Isoform 2 of AP-4 complex accessory subunit tepsin

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96N21-1-unknown	MAAAPP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96N21-153-unknown	MGSQAR...	153	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67164
Q96N21-193-unknown	SGPSSQ...	193	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2295
Q96N21-193-unknown	SGPSSQ...	193	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142914
Q96N21-381-unknown	AVPLPG...	381	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172014
Q96N21-381-	AVPLPG...	381		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...WDELDS	192	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2295
...AFLNA	525	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AFLNA	525	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt62782
...AFLNA	525		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AFLNA	525		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	192	ELDS.\|.SGPS	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> AP4AT_HUMAN @192

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)