Q96RK0: Protein capicua homolog

General Information

Protein names	- Protein capicua homolog
Gene names	CIC
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96RK0

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MYSAHRPLMP ASSAASRGLG MFVWTNVEPR SVAVFPWHSL VPFLAPSQPD PSVQPSEAQQ
        70         80         90        100        110        120
PASHPVASNQ SKEPAESAAV AHERPPGGTG SADPERPPGA TCPESPGPGP PHPLGVVESG
       130        140        150        160        170        180
KGPPPTTEEE ASGPPGEPRL DSETESDHDD AFLSIMSPEI QLPLPPGKRR TQSLSALPKE
       190        200        210        220        230        240
RDSSSEKDGR SPNKREKDHI RRPMNAFMIF SKRHRALVHQ RHPNQDNRTV SKILGEWWYA
       250        260        270        280        290        300
LGPKEKQKYH DLAFQVKEAH FKAHPDWKWC NKDRKKSSSE AKPTSLGLAG GHKETRERSM
       310        320        330        340        350        360
SETGTAAAPG VSSELLSVAA QTLLSSDTKA PGSSSCGAER LHTVGGPGSA RPRAFSHSGV
       370        380        390        400        410        420
HSLDGGEVDS QALQELTQMV SGPASYSGPK PSTQYGAPGP FAAPGEGGAL AATGRPPLLP
       430        440        450        460        470        480
TRASRSQRAA SEDMTSDEER MVICEEEGDD DVIADDGFGT TDIDLKCKER VTDSESGDSS
       490        500        510        520        530        540
GEDPEGNKGF GRKVFSPVIR SSFTHCRPPL DPEPPGPPDP PVAFGKGYGS APSSSASSPA
       550        560        570        580        590        600
SSSASAATSF SLGSGTFKAQ ESGQGSTAGP LRPPPPGAGG PATPSKATRF LPMDPATFRR
       610        620        630        640        650        660
KRPESVGGLE PPGPSVIAAP PSGGGNILQT LVLPPNKEEQ EGGGARVPSA PAPSLAYGAP
       670        680        690        700        710        720
AAPLSRPAAT MVTNVVRPVS STPVPIASKP FPTSGRAEAS PNDTAGARTE MGTGSRVPGG
       730        740        750        760        770        780
SPLGVSLVYS DKKSAAATSP APHLVAGPLL GTVGKAPATV TNLLVGTPGY GAPAPPAVQF
       790        800        810        820        830        840
IAQGAPGGGT TAGSGAGAGS GPNGPVPLGI LQPGALGKAG GITQVQYILP TLPQQLQVAP
       850        860        870        880        890        900
APAPAPGTKA AAPSGPAPTT SIRFTLPPGT STNGKVLAAT APTPGIPILQ SVPSAPPPKA
       910        920        930        940        950        960
QSVSPVQAPP PGGSAQLLPG KVLVPLAAPS MSVRGGGAGQ PLPLVSPPFS VPVQNGAQPP
       970        980        990       1000       1010       1020
SKIIQLTPVP VSTPSGLVPP LSPATLPGPT SQPQKVLLPS STRITYVQSA GGHALPLGTS
      1030       1040       1050       1060       1070       1080
PASSQAGTVT SYGPTSSVAL GFTSLGPSGP AFVQPLLSAG QAPLLAPGQV GVSPVPSPQL
      1090       1100       1110       1120       1130       1140
PPACAAPGGP VITAFYSGSP APTSSAPLAQ PSQAPPSLVY TVATSTTPPA ATILPKGPPA
      1150       1160       1170       1180       1190       1200
PATATPAPTS PFPSATAGSM TYSLVAPKAQ RPSPKAPQKV KAAIASIPVG SFEAGASGRP
      1210       1220       1230       1240       1250       1260
GPAPRQPLEP GPVREPTAPE SELEGQPTPP APPPLPETWT PTARSSPPLP PPAEERTSAK
      1270       1280       1290       1300       1310       1320
GPETMASKFP SSSSDWRVPG QGLENRGEPP TPPSPAPAPA VAPGGSSESS SGRAAGDTPE
      1330       1340       1350       1360       1370       1380
RKEAAGTGKK VKVRPPPLKK TFDSVDNRVL SEVDFEERFA ELPEFRPEEV LPSPTLQSLA
      1390       1400       1410       1420       1430       1440
TSPRAILGSY RKKRKNSTDL DSAPEDPTSP KRKMRRRSSC SSEPNTPKSA KCEGDIFTFD
      1450       1460       1470       1480       1490       1500
RTGTEAEDVL GELEYDKVPY SSLRRTLDQR RALVMQLFQD HGFFPSAQAT AAFQARYADI
      1510       1520       1530       1540       1550       1560
FPSKVCLQLK IREVRQKIMQ AATPTEQPPG AEAPLPVPPP TGTAAAPAPT PSPAGGPDPT
      1570       1580       1590       1600
SPSSDSGTAQ AAPPLPPPPE SGPGQPGWEG APQPSPPPPG PSTAATGR

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

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Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96RK0-1-unknown	MYSAHR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96RK0-457-	GFGTTD...	457		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96RK0-457-	GFGTTD...	457		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96RK0-1225-	GQPTPP...	1225		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q96RK0-1225-	GQPTPP...	1225		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96RK0-1271-unknown	SSSSDW...	1271	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000458543

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PPESGP	1582	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000458543
	...AATGR	1608	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)