Q96RL1: BRCA1-A complex subunit RAP80

General Information

Protein names	- BRCA1-A complex subunit RAP80 - Receptor-associated protein 80 - Retinoid X receptor-interacting protein 110 - Ubiquitin interaction motif-containing protein 1
Gene names	UIMC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96RL1

3 N-termini

1 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of BRCA1-A complex subunit RAP80 - Isoform 3 of BRCA1-A complex subunit RAP80 - Isoform 4 of BRCA1-A complex subunit RAP80 - Isoform 5 of BRCA1-A complex subunit RAP80

Sequence View

        10         20         30         40         50         60
MPRRKKKVKE VSESRNLEKK DVETTSSVSV KRKRRLEDAF IVISDSDGEE PKEENGLQKT
        70         80         90        100        110        120
KTKQSNRAKC LAKRKIAQMT EEEQFALALK MSEQEAREVN SQEEEEEELL RKAIAESLNS
       130        140        150        160        170        180
CRPSDASATR SRPLATGPSS QSHQEKTTDS GLTEGIWQLV PPSLFKGSHI SQGNEAEERE
       190        200        210        220        230        240
EPWDHTEKTE EEPVSGSSGS WDQSSQPVFE NVNVKSFDRC TGHSAEHTQC GKPQESTGRG
       250        260        270        280        290        300
SAFLKAVQGS GDTSRHCLPT LADAKGLQDT GGTVNYFWGI PFCPDGVDPN QYTKVILCQL
       310        320        330        340        350        360
EVYQKSLKMA QRQLLNKKGF GEPVLPRPPS LIQNECGQGE QASEKNECIS EDMGDEDKEE
       370        380        390        400        410        420
RQESRASDWH SKTKDFQESS IKSLKEKLLL EEEPTTSHGQ SSQGIVEETS EEGNSVPASQ
       430        440        450        460        470        480
SVAALTSKRS LVLMPESSAE EITVCPETQL SSSETFDLER EVSPGSRDIL DGVRIIMADK
       490        500        510        520        530        540
EVGNKEDAEK EVAISTFSSS NQVSCPLCDQ CFPPTKIERH AMYCNGLMEE DTVLTRRQKE
       550        560        570        580        590        600
AKTKSDSGTA AQTSLDIDKN EKCYLCKSLV PFREYQCHVD SCLQLAKADQ GDGPEGSGRA
       610        620        630        640        650        660
CSTVEGKWQQ RLKNPKEKGH SEGRLLSFLE QSEHKTSDAD IKSSETGAFR VPSPGMEEAG
       670        680        690        700        710
CSREMQSSFT RRDLNESPVK SFVSISEATD CLVDFKKQVT VQPGSRTRTK AGRGRRRKF         10         20         30         40         50         60
MPRRKKKVKE VSESRNLEKK DVETTSSVSV KRKRRLEDAF IVISDSDGEE PKEENGLQKT
        70         80         90        100        110        120
KTKQSNRAKC LAKRKIAQMT EEEQFALALK MSEQEAREVN SQEEEEEELL RKAIAESLNS
       130        140        150        160        170        180
CRPSDASATR SRPLATGPSS QSHQEKTTDS GLTEGIWQLV PPSLFKGSHI SQGNEAEERE
       190        200        210        220        230        240
EPWDHTEKTE EEPVSGSSGS WDQSSQPVFE NVNVKSFDRC TGHSAEHTQC GKPQESTGRG
       250        260        270        280        290        300
SAFLKAVQGS GDTSRHCLPT LADAKGLQDT GGTVNYFWGI PFCPDGVDPN QYTKVILCQL
       310        320        330        340        350        360
EVYQKSLKMA QRQLLNKKGF GEPVLPRPPS LIQNECGQGE QASEKNECIS EDMGDEDKEE
       370        380        390        400        410        420
RQESRASDWH SKTKDFQESS IKSLKEKLLL EEEPTTSHGQ SSQGIVEETS EEGNSVPASQ
       430        440        450        460        470        480
SVAALTSKRS LVLMPESSAE EITVCPETQL SSSETFDLER EVSPGSRDIL DGVRIIMADK
       490        500        510        520        530        540
EVGNKEDAEK EVAISTFSSS NQVSCPLCDQ CFPPTKIERH AMYCNGLMEE DTVLTRRQKE
       550        560        570        580        590        600
AKTKSDSGTA AQTSLDIDKN EKCYLCKSLV PFREYQCHVD SCLQLAKADQ GDGPEGSGRA
       610        620        630        640        650        660
CSTVEGKWQQ RLKNPKEKGH SEGRLLSFLE QSEHKTSDAD IKSSETGAFR VPSPGMEEAG
       670        680        690        700        710
CSREMQSSFT RRDLNESPVK SFVSISEATD CLVDFKKQVT VQPGSRTRTK AGRGRRRKF         10         20         30         40         50         60
MPRRKKKVKE VSESRNLEKK DVETTSSVSV KRKRRLEDAF IVISDSDGEE PKEENGLQKT
        70         80         90        100        110        120
KTKQSNRAKC LAKRKIAQMT EEEQFALALK MSEQEAREVN SQEEEEEELL RKAIAESLNS
       130        140        150        160        170        180
CRPSDASATR SRPLATGPSS QSHQEKTTDS GLTEGIWQLV PPSLFKGSHI SQGNEAEERE
       190        200        210        220        230        240
EPWDHTEKTE EEPVSGSSGS WDQSSQPVFE NVNVKSFDRC TGHSAEHTQC GKPQESTGRG
       250        260        270        280        290        300
SAFLKAVQGS GDTSRHCLPT LADAKGLQDT GGTVNYFWGI PFCPDGVDPN QYTKVILCQL
       310        320        330        340        350        360
EVYQKSLKMA QRQLLNKKGF GEPVLPRPPS LIQNECGQGE QASEKNECIS EDMGDEDKEE
       370        380        390        400        410        420
RQESRASDWH SKTKDFQESS IKSLKEKLLL EEEPTTSHGQ SSQGIVEETS EEGNSVPASQ
       430        440        450        460        470        480
SVAALTSKRS LVLMPESSAE EITVCPETQL SSSETFDLER EVSPGSRDIL DGVRIIMADK
       490        500        510        520        530        540
EVGNKEDAEK EVAISTFSSS NQVSCPLCDQ CFPPTKIERH AMYCNGLMEE DTVLTRRQKE
       550        560        570        580        590        600
AKTKSDSGTA AQTSLDIDKN EKCYLCKSLV PFREYQCHVD SCLQLAKADQ GDGPEGSGRA
       610        620        630        640        650        660
CSTVEGKWQQ RLKNPKEKGH SEGRLLSFLE QSEHKTSDAD IKSSETGAFR VPSPGMEEAG
       670        680        690        700        710
CSREMQSSFT RRDLNESPVK SFVSISEATD CLVDFKKQVT VQPGSRTRTK AGRGRRRKF         10         20         30         40         50         60
MPRRKKKVKE VSESRNLEKK DVETTSSVSV KRKRRLEDAF IVISDSDGEE PKEENGLQKT
        70         80         90        100        110        120
KTKQSNRAKC LAKRKIAQMT EEEQFALALK MSEQEAREVN SQEEEEEELL RKAIAESLNS
       130        140        150        160        170        180
CRPSDASATR SRPLATGPSS QSHQEKTTDS GLTEGIWQLV PPSLFKGSHI SQGNEAEERE
       190        200        210        220        230        240
EPWDHTEKTE EEPVSGSSGS WDQSSQPVFE NVNVKSFDRC TGHSAEHTQC GKPQESTGRG
       250        260        270        280        290        300
SAFLKAVQGS GDTSRHCLPT LADAKGLQDT GGTVNYFWGI PFCPDGVDPN QYTKVILCQL
       310        320        330        340        350        360
EVYQKSLKMA QRQLLNKKGF GEPVLPRPPS LIQNECGQGE QASEKNECIS EDMGDEDKEE
       370        380        390        400        410        420
RQESRASDWH SKTKDFQESS IKSLKEKLLL EEEPTTSHGQ SSQGIVEETS EEGNSVPASQ
       430        440        450        460        470        480
SVAALTSKRS LVLMPESSAE EITVCPETQL SSSETFDLER EVSPGSRDIL DGVRIIMADK
       490        500        510        520        530        540
EVGNKEDAEK EVAISTFSSS NQVSCPLCDQ CFPPTKIERH AMYCNGLMEE DTVLTRRQKE
       550        560        570        580        590        600
AKTKSDSGTA AQTSLDIDKN EKCYLCKSLV PFREYQCHVD SCLQLAKADQ GDGPEGSGRA
       610        620        630        640        650        660
CSTVEGKWQQ RLKNPKEKGH SEGRLLSFLE QSEHKTSDAD IKSSETGAFR VPSPGMEEAG
       670        680        690        700        710
CSREMQSSFT RRDLNESPVK SFVSISEATD CLVDFKKQVT VQPGSRTRTK AGRGRRRKF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q96RL1-1-unknown	MPRRKK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q96RL1-1-unknown	MPRRKK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93864
Q96RL1-1-unknown	MPRRKK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93867
Q96RL1-5-unknown	KKKVKE...	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13112
Q96RL1-5-unknown	KKKVKE...	5	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194659
Q96RL1-5-unknown	KKKVKE...	5	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194660
Q96RL1-79-unknown	MTEEEQ...	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93865
Q96RL1-79-unknown	MTEEEQ...	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105344
Q96RL1-79-unknown	MTEEEQ...	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105345

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRRKF	719	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RRRKF	719	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89484
...RRRKF	719	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89482
...RRRKF	719	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89483

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	4	PRRK.\|.KKKV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)