Q96ST3: Paired amphipathic helix protein Sin3a

General Information

Protein names	- Paired amphipathic helix protein Sin3a - Histone deacetylase complex subunit Sin3a - Transcriptional corepressor Sin3a
Gene names	SIN3A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96ST3

4 N-termini

9 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKRRLDDQES PVYAAQQRRI PGSTEAFPHQ HRVLAPAPPV YEAVSETMQS ATGIQYSVTP
        70         80         90        100        110        120
SYQVSAMPQS SGSHGPAIAA VHSSHHHPTA VQPHGGQVVQ SHAHPAPPVA PVQGQQQFQR
       130        140        150        160        170        180
LKVEDALSYL DQVKLQFGSQ PQVYNDFLDI MKEFKSQSID TPGVISRVSQ LFKGHPDLIM
       190        200        210        220        230        240
GFNTFLPPGY KIEVQTNDMV NVTTPGQVHQ IPTHGIQPQP QPPPQHPSQP SAQSAPAPAQ
       250        260        270        280        290        300
PAPQPPPAKV SKPSQLQAHT PASQQTPPLP PYASPRSPPV QPHTPVTISL GTAPSLQNNQ
       310        320        330        340        350        360
PVEFNHAINY VNKIKNRFQG QPDIYKAFLE ILHTYQKEQR NAKEAGGNYT PALTEQEVYA
       370        380        390        400        410        420
QVARLFKNQE DLLSEFGQFL PDANSSVLLS KTTAEKVDSV RNDHGGTVKK PQLNNKPQRP
       430        440        450        460        470        480
SQNGCQIRRH PTGTTPPVKK KPKLLNLKDS SMADASKHGG GTESLFFDKV RKALRSAEAY
       490        500        510        520        530        540
ENFLRCLVIF NQEVISRAEL VQLVSPFLGK FPELFNWFKN FLGYKESVHL ETYPKERATE
       550        560        570        580        590        600
GIAMEIDYAS CKRLGSSYRA LPKSYQQPKC TGRTPLCKEV LNDTWVSFPS WSEDSTFVSS
       610        620        630        640        650        660
KKTQYEEHIY RCEDERFELD VVLETNLATI RVLEAIQKKL SRLSAEEQAK FRLDNTLGGT
       670        680        690        700        710        720
SEVIHRKALQ RIYADKAADI IDGLRKNPSI AVPIVLKRLK MKEEEWREAQ RGFNKVWREQ
       730        740        750        760        770        780
NEKYYLKSLD HQGINFKQND TKVLRSKSLL NEIESIYDER QEQATEENAG VPVGPHLSLA
       790        800        810        820        830        840
YEDKQILEDA AALIIHHVKR QTGIQKEDKY KIKQIMHHFI PDLLFAQRGD LSDVEEEEEE
       850        860        870        880        890        900
EMDVDEATGA VKKHNGVGGS PPKSKLLFSN TAAQKLRGMD EVYNLFYVNN NWYIFMRLHQ
       910        920        930        940        950        960
ILCLRLLRIC SQAERQIEEE NREREWEREV LGIKRDKSDS PAIQLRLKEP MDVDVEDYYP
       970        980        990       1000       1010       1020
AFLDMVRSLL DGNIDSSQYE DSLREMFTIH AYIAFTMDKL IQSIVRQLQH IVSDEICVQV
      1030       1040       1050       1060       1070       1080
TDLYLAENNN GATGGQLNTQ NSRSLLESTY QRKAEQLMSD ENCFKLMFIQ SQGQVQLTIE
      1090       1100       1110       1120       1130       1140
LLDTEEENSD DPVEAERWSD YVERYMNSDT TSPELREHLA QKPVFLPRNL RRIRKCQRGR
      1150       1160       1170       1180       1190       1200
EQQEKEGKEG NSKKTMENVD SLDKLECRFK LNSYKMVYVI KSEDYMYRRT ALLRAHQSHE
      1210       1220       1230       1240       1250       1260
RVSKRLHQRF QAWVDKWTKE HVPREMAAET SKWLMGEGLE GLVPCTTTCD TETLHFVSIN
      1270
KYRVKYGTVF KAP

Isoforms

Sequence View

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Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

4 N-termini - 9 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96ST3-1-unknown	MKRRLD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96ST3-48-unknown	MQSATG...	48	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q96ST3-101-	SHAHPA...	101		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96ST3-548-unknown	YASCKR...	548	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13125

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...HGGQVV	98	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000456997
...AHPAPP	107	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000455644
...QRLKVE	123	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000455662
...ALSYLD	130	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000454750
...GSQPQV	142	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000455072
...FKGHPD	176	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000455204
...AMEIDY	547	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13125
...VFKAP	1273		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VFKAP	1273	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VFKAP	1273		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	547	EIDY.\|.YASC	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)