Q99633: Pre-mRNA-splicing factor 18

General Information

Protein names	- Pre-mRNA-splicing factor 18 - PRP18 homolog - hPRP18
Gene names	PRPF18
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99633

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDILKSEILR KRQLVEDRNL LVENKKYFKR SELAKKEEEA YFERCGYKIQ PKEEDQKPLT
        70         80         90        100        110        120
SSNPVLELEL AEEKLPMTLS RQEVIRRLRE RGEPIRLFGE TDYDAFQRLR KIEILTPEVN
       130        140        150        160        170        180
KGLRNDLKAA LDKIDQQYLN EIVGGQEPGE EDTQNDLKVH EENTTIEELE ALGESLGKGD
       190        200        210        220        230        240
DHKDMDIITK FLKFLLGVWA KELNAREDYV KRSVQGKLNS ATQKQTESYL RPLFRKLRKR
       250        260        270        280        290        300
NLPADIKESI TDIIKFMLQR EYVKANDAYL QMAIGNAPWP IGVTMVGIHA RTGREKIFSK
       310        320        330        340
HVAHVLNDET QRKYIQGLKR LMTICQKHFP TDPSKCVEYN AL

Isoforms

- Isoform 2 of Pre-mRNA-splicing factor 18

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99633-1-Acetylation	MDILKS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99633-1-Acetylation	MDILKS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q99633-1-Acetylation	MDILKS...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97953
Q99633-1-unknown	MDILKS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86260
Q99633-1-unknown	MDILKS...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q99633-2-unknown	DILKSE...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q99633-19-unknown	NLLVEN...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10495

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LVEDRN	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10495
...IGVTMV	285	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81878
...EYNAL	342	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	18	EDRN.\|.NLLV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)