Q99714: 3-hydroxyacyl-CoA dehydrogenase type-2

General Information

Protein names	- 3-hydroxyacyl-CoA dehydrogenase type-2 - 1.1.1.35 {ECO:0000269\|PubMed:12917011, ECO:0000269\|PubMed:18996107, ECO:0000269\|PubMed:25925575, ECO:0000269\|PubMed:28888424, ECO:0000269\|PubMed:9553139} - 17-beta-hydroxysteroid dehydrogenase 10 - 17-beta-HSD 10 - 1.1.1.51 {ECO:0000269\|PubMed:12917011, ECO:0000269\|PubMed:28888424} - 2-methyl-3-hydroxybutyryl-CoA dehydrogenase {ECO:0000303\|PubMed:16148061} - MHBD {ECO:0000303\|PubMed:16148061} - 3-hydroxy-2-methylbutyryl-CoA dehydrogenase - 1.1.1.178 {ECO:0000269\|PubMed:12917011} - 3-hydroxyacyl-CoA dehydrogenase type II - Endoplasmic reticulum-associated amyloid beta-peptide-binding protein - Mitochondrial ribonuclease P protein 2 - Mitochondrial RNase P protein 2 - Short chain dehydrogenase/reductase family 5C member 1 - Short-chain type dehydrogenase/reductase XH98G2 - Type II HADH
Gene names	HSD17B10
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99714

9 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAACRSVKG LVAVITGGAS GLGLATAERL VGQGASAVLL DLPNSGGEAQ AKKLGNNCVF
        70         80         90        100        110        120
APADVTSEKD VQTALALAKG KFGRVDVAVN CAGIAVASKT YNLKKGQTHT LEDFQRVLDV
       130        140        150        160        170        180
NLMGTFNVIR LVAGEMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIVGMTL
       190        200        210        220        230        240
PIARDLAPIG IRVMTIAPGL FGTPLLTSLP EKVCNFLASQ VPFPSRLGDP AEYAHLVQAI
       250        260
IENPFLNGEV IRLDGAIRMQ P

Isoforms

- Isoform 2 of 3-hydroxyacyl-CoA dehydrogenase type-2

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99714-1-unknown	MAAACR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76779
Q99714-2-unknown	MAAACR...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q99714-2-unknown	MAAACR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99714-2-Acetylation	AAACRS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99714-2-Acetylation	AAACRS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110732
Q99714-2-Acetylation	AAACRS...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q99714-59-unknown	VFAPAD...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15496
Q99714-59-unknown	VFAPAD...	59		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139826
Q99714-59-	VFAPAD...	59			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q99714-105-unknown	KGQTHT...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165860
Q99714-105-	KGQTHT...	105			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q99714-169-unknown	SASKGG...	169		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171445
Q99714-169-	SASKGG...	169			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LGNNCV	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15496
...LGNNCV	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122925
...IRMQP	261	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IRMQP	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72397

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
HTRA2_HUMAN	58	NNCV.\|.VFAP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)