Q99829: Copine-1 {ECO:0000305}

General Information

Protein names	- Copine-1 {ECO:0000305} - Chromobindin 17 {ECO:0000303\|PubMed:9430674} - Copine I {ECO:0000303\|PubMed:9430674, ECO:0000312\|HGNC:HGNC:2314}
Gene names	CPNE1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99829

4 N-termini

15 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAHCVTLVQL SISCDHLIDK DIGSKSDPLC VLLQDVGGGS WAELGRTERV RNCSSPEFSK
        70         80         90        100        110        120
TLQLEYRFET VQKLRFGIYD IDNKTPELRD DDFLGGAECS LGQIVSSQVL TLPLMLKPGK
       130        140        150        160        170        180
PAGRGTITVS AQELKDNRVV TMEVEARNLD KKDFLGKSDP FLEFFRQGDG KWHLVYRSEV
       190        200        210        220        230        240
IKNNLNPTWK RFSVPVQHFC GGNPSTPIQV QCSDYDSDGS HDLIGTFHTS LAQLQAVPAE
       250        260        270        280        290        300
FECIHPEKQQ KKKSYKNSGT IRVKICRVET EYSFLDYVMG GCQINFTVGV DFTGSNGDPS
       310        320        330        340        350        360
SPDSLHYLSP TGVNEYLMAL WSVGSVVQDY DSDKLFPAFG FGAQVPPDWQ VSHEFALNFN
       370        380        390        400        410        420
PSNPYCAGIQ GIVDAYRQAL PQVRLYGPTN FAPIINHVAR FAAQAAHQGT ASQYFMLLLL
       430        440        450        460        470        480
TDGAVTDVEA TREAVVRASN LPMSVIIVGV GGADFEAMEQ LDADGGPLHT RSGQAAARDI
       490        500        510        520        530
VQFVPYRRFQ NAPREALAQT VLAEVPTQLV SYFRAQGWAP LKPLPPSAKD PAQAPQA

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 15 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99829-1-unknown	MAHCVT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99829-76-	FGIYDI...	76		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q99829-463-unknown	ADGGPL...	463	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8046
Q99829-465-	GGPLHT...	465		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q99829-465-	GGPLHT...	465		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LQLEYR	66	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412806
...QELKDN	136	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409955
...NLDKKD	152	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000391483
...GKWHLV	174	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000397638
...QHFCGG	201	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000409794
...STPIQV	209	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000401915
...FHTSLA	231	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000387434
...QLQAVP	237	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000389662
...SSPDSL	304	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000404355
...SVVQDY	329	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000416962
...AHQGTA	410	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000390626
...MEQLDA	462	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8046
...DPAQAP	534	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000415597
...QAPQA	537		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...QAPQA	537	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...QAPQA	537		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	462	QLDA.\|.ADGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)