Q99873: Protein arginine N-methyltransferase 1 {ECO:0000305}

General Information

Protein names	- Protein arginine N-methyltransferase 1 {ECO:0000305} - 2.1.1.319 {ECO:0000269\|PubMed:11387442, ECO:0000269\|PubMed:11448779, ECO:0000269\|PubMed:19405910, ECO:0000269\|PubMed:26575292, ECO:0000269\|PubMed:28040436} - Histone-arginine N-methyltransferase PRMT1 - Interferon receptor 1-bound protein 4
Gene names	PRMT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99873

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein arginine N-methyltransferase 1 - Isoform 3 of Protein arginine N-methyltransferase 1 - Isoform 4 of Protein arginine N-methyltransferase 1 - Isoform 3 of Protein arginine N-methyltransferase 1 - Isoform 4 of Protein arginine N-methyltransferase 1

Sequence View

        10         20         30         40         50         60
MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF
        70         80         90        100        110        120
GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS
       130        140        150        160        170        180
SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA
       190        200        210        220        230        240
RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV
       250        260        270        280        290        300
DPKQLVTNAC LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG
       310        320        330        340        350        360
FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT IDLDFKGQLC
       370
ELSCSTDYRM R         10         20         30         40         50         60
MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF
        70         80         90        100        110        120
GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS
       130        140        150        160        170        180
SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA
       190        200        210        220        230        240
RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV
       250        260        270        280        290        300
DPKQLVTNAC LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG
       310        320        330        340        350        360
FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT IDLDFKGQLC
       370
ELSCSTDYRM R         10         20         30         40         50         60
MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF
        70         80         90        100        110        120
GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS
       130        140        150        160        170        180
SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA
       190        200        210        220        230        240
RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV
       250        260        270        280        290        300
DPKQLVTNAC LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG
       310        320        330        340        350        360
FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT IDLDFKGQLC
       370
ELSCSTDYRM R         10         20         30         40         50         60
MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF
        70         80         90        100        110        120
GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS
       130        140        150        160        170        180
SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA
       190        200        210        220        230        240
RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV
       250        260        270        280        290        300
DPKQLVTNAC LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG
       310        320        330        340        350        360
FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT IDLDFKGQLC
       370
ELSCSTDYRM R         10         20         30         40         50         60
MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK DYYFDSYAHF
        70         80         90        100        110        120
GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG ILCMFAAKAG ARKVIGIECS
       130        140        150        160        170        180
SISDYAVKIV KANKLDHVVT IIKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVLYA
       190        200        210        220        230        240
RDKWLAPDGL IFPDRATLYV TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV
       250        260        270        280        290        300
DPKQLVTNAC LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG
       310        320        330        340        350        360
FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT IDLDFKGQLC
       370
ELSCSTDYRM R

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q99873-1-unknown	MAAAEA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99873-324-unknown	TVKTGE...	324	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4228
Q99873-324-unknown	TVKTGE...	324	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150031
Q99873-324-unknown	TVKTGE...	324	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150126
Q99873-324-unknown	TVKTGE...	324	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150243

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MEDYLT	323	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4228
...GQLCEL	361	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GQLCEL	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62592
...GQLCEL	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62591
...GQLCEL	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62593

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	323	DYLT.\|.TVKT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)