Q99961: Endophilin-A2

General Information

Protein names	- Endophilin-A2 - EEN fusion partner of MLL - Endophilin-2 - Extra eleven-nineteen leukemia fusion gene protein - EEN - SH3 domain protein 2B - SH3 domain-containing GRB2-like protein 1
Gene names	SH3GL1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99961

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Endophilin-A2 - Isoform 3 of Endophilin-A2

Sequence View

        10         20         30         40         50         60
MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKEMEKKV DVTSKAVTEV LARTIEYLQP
        70         80         90        100        110        120
NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMIRH GKELGGESNF GDALLDAGES
       130        140        150        160        170        180
MKRLAEVKDS LDIEVKQNFI DPLQNLCEKD LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD
       190        200        210        220        230        240
EELRQALEKF EESKEVAETS MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILDELAEKL
       250        260        270        280        290        300
KRRMREASSR PKREYKPKPR EPFDLGEPEQ SNGGFPCTTA PKIAASSSFR SSDKPIRTPS
       310        320        330        340        350        360
RSMPPLDQPS CKALYDFEPE NDGELGFHEG DVITLTNQID ENWYEGMLDG QSGFFPLSYV

EVLVPLPQ         10         20         30         40         50         60
MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKEMEKKV DVTSKAVTEV LARTIEYLQP
        70         80         90        100        110        120
NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMIRH GKELGGESNF GDALLDAGES
       130        140        150        160        170        180
MKRLAEVKDS LDIEVKQNFI DPLQNLCEKD LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD
       190        200        210        220        230        240
EELRQALEKF EESKEVAETS MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILDELAEKL
       250        260        270        280        290        300
KRRMREASSR PKREYKPKPR EPFDLGEPEQ SNGGFPCTTA PKIAASSSFR SSDKPIRTPS
       310        320        330        340        350        360
RSMPPLDQPS CKALYDFEPE NDGELGFHEG DVITLTNQID ENWYEGMLDG QSGFFPLSYV

EVLVPLPQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99961-1-unknown	MSVAGL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99961-1-unknown	MSVAGL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89530
Q99961-1-unknown	MSVAGL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89531
Q99961-9-unknown	QFYKAS...	9		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q99961-9-unknown	QFYKAS...	9	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160280
Q99961-9-unknown	QFYKAS...	9	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160281
Q99961-9-	QFYKAS...	9		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q99961-113-unknown	ALLDAG...	113	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13154
Q99961-113-unknown	ALLDAG...	113	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197137

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SNFGDA	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13154
...VPLPQ	368	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VPLPQ	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85149
...VPLPQ	368	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85148

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	112	FGDA.\|.ALLD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)