Q9BRT8: COBW domain-containing protein 1

General Information

Protein names	- COBW domain-containing protein 1 - Cobalamin synthase W domain-containing protein 1 - COBP - NPC-A-6 COBW domain-containing protein 1 - NPC-A-6
Gene names	CBWD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BRT8

3 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of COBW domain-containing protein 1 - Isoform 3 of COBW domain-containing protein 1 - Isoform 4 of COBW domain-containing protein 1

Sequence View

        10         20         30         40         50         60
MLPAVGSADE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN
        70         80         90        100        110        120
YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDSGLRAI
       130        140        150        160        170        180
ENLMQKKGKF DYILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE
       190        200        210        220        230        240
EKPDGLINEA TRQVALADAI LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS
       250        260        270        280        290        300
NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
       310        320        330        340        350        360
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLL
       370        380        390
GRNLDKDILK QLFIATVTET EKQWTTRFQE DQVCT         10         20         30         40         50         60
MLPAVGSADE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN
        70         80         90        100        110        120
YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDSGLRAI
       130        140        150        160        170        180
ENLMQKKGKF DYILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE
       190        200        210        220        230        240
EKPDGLINEA TRQVALADAI LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS
       250        260        270        280        290        300
NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
       310        320        330        340        350        360
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLL
       370        380        390
GRNLDKDILK QLFIATVTET EKQWTTRFQE DQVCT         10         20         30         40         50         60
MLPAVGSADE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN
        70         80         90        100        110        120
YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDSGLRAI
       130        140        150        160        170        180
ENLMQKKGKF DYILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE
       190        200        210        220        230        240
EKPDGLINEA TRQVALADAI LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS
       250        260        270        280        290        300
NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
       310        320        330        340        350        360
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLL
       370        380        390
GRNLDKDILK QLFIATVTET EKQWTTRFQE DQVCT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BRT8-1-unknown	MLPAVG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BRT8-1-unknown	MLPAVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69481
Q9BRT8-1-unknown	MLPAVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69482
Q9BRT8-1-	MLPAVG...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9BRT8-197-unknown	ADAILI...	197	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14926
Q9BRT8-197-unknown	ADAILI...	197	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145179
Q9BRT8-197-unknown	ADAILI...	197	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146491

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...CCSVKD	113	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt65100
...CCSVKD	113	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt91537
...CCSVKD	113	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt91536
...RQVALA	196	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14926
...RQVALA	196	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt128467
...RQVALA	196	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129799
...DQVCT	395		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DQVCT	395		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...DQVCT	395	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DQVCT	395	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt65098
...DQVCT	395	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt65099
...DQVCT	395		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DQVCT	395		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	196	VALA.\|.ADAI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)