TopFIND 4.0

Q9BUB5: MAP kinase-interacting serine/threonine-protein kinase 1

General Information

Protein names
- MAP kinase-interacting serine/threonine-protein kinase 1
- 2.7.11.1 {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:9155018}
- MAP kinase signal-integrating kinase 1
- MAPK signal-integrating kinase 1
- Mnk1
Gene names MKNK1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9BUB5

4

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL TSELLGEGAY 
        70         80         90        100        110        120 
AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ CQGNKNILEL IEFFEDDTRF 
       130        140        150        160        170        180 
YLVFEKLQGG SILAHIQKQK HFNEREASRV VRDVAAALDF LHTKDKVSLC HLGWSAMAPS 
       190        200        210        220        230        240 
GLTAAPTSLG SSDPPTSASQ VAGTTGIAHR DLKPENILCE SPEKVSPVKI CDFDLGSGMK 
       250        260        270        280        290        300 
LNNSCTPITT PELTTPCGSA EYMAPEVVEV FTDQATFYDK RCDLWSLGVV LYIMLSGYPP 
       310        320        330        340        350        360 
FVGHCGADCG WDRGEVCRVC QNKLFESIQE GKYEFPDKDW AHISSEAKDL ISKLLVRDAK 
       370        380        390        400        410        420 
QRLSAAQVLQ HPWVQGQAPE KGLPTPQVLQ RNSSTMDLTL FAAEAIALNR QLSQHEENEL 
       430        440        450        460    
AEEPEALADG LCSMKLSPPC KSRLARRRAL AQAGRGEDRS PPTAL

Isoforms

- Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 - Isoform 3 of MAP kinase-interacting serine/threonine-protein kinase 1

Sequence View

        10         20         30         40         50         60 
MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL TSELLGEGAY 
        70         80         90        100        110        120 
AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ CQGNKNILEL IEFFEDDTRF 
       130        140        150        160        170        180 
YLVFEKLQGG SILAHIQKQK HFNEREASRV VRDVAAALDF LHTKDKVSLC HLGWSAMAPS 
       190        200        210        220        230        240 
GLTAAPTSLG SSDPPTSASQ VAGTTGIAHR DLKPENILCE SPEKVSPVKI CDFDLGSGMK 
       250        260        270        280        290        300 
LNNSCTPITT PELTTPCGSA EYMAPEVVEV FTDQATFYDK RCDLWSLGVV LYIMLSGYPP 
       310        320        330        340        350        360 
FVGHCGADCG WDRGEVCRVC QNKLFESIQE GKYEFPDKDW AHISSEAKDL ISKLLVRDAK 
       370        380        390        400        410        420 
QRLSAAQVLQ HPWVQGQAPE KGLPTPQVLQ RNSSTMDLTL FAAEAIALNR QLSQHEENEL 
       430        440        450        460    
AEEPEALADG LCSMKLSPPC KSRLARRRAL AQAGRGEDRS PPTAL         10         20         30         40         50         60 
MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL TSELLGEGAY 
        70         80         90        100        110        120 
AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ CQGNKNILEL IEFFEDDTRF 
       130        140        150        160        170        180 
YLVFEKLQGG SILAHIQKQK HFNEREASRV VRDVAAALDF LHTKDKVSLC HLGWSAMAPS 
       190        200        210        220        230        240 
GLTAAPTSLG SSDPPTSASQ VAGTTGIAHR DLKPENILCE SPEKVSPVKI CDFDLGSGMK 
       250        260        270        280        290        300 
LNNSCTPITT PELTTPCGSA EYMAPEVVEV FTDQATFYDK RCDLWSLGVV LYIMLSGYPP 
       310        320        330        340        350        360 
FVGHCGADCG WDRGEVCRVC QNKLFESIQE GKYEFPDKDW AHISSEAKDL ISKLLVRDAK 
       370        380        390        400        410        420 
QRLSAAQVLQ HPWVQGQAPE KGLPTPQVLQ RNSSTMDLTL FAAEAIALNR QLSQHEENEL 
       430        440        450        460    
AEEPEALADG LCSMKLSPPC KSRLARRRAL AQAGRGEDRS PPTAL



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Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PPTAL 465 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...PPTAL 465 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt76848

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)