Q9BWE0: Replication initiator 1

General Information

Protein names	- Replication initiator 1 - 60 kDa origin-specific DNA-binding protein - 60 kDa replication initiation region protein - ATT-binding protein - DHFR oribeta-binding protein RIP60 - Zinc finger protein 464
Gene names	REPIN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BWE0

2 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLERRCRGPL AMGLAQPRLL SGPSQESPQT LGKESRGLRQ QGTSVAQSGA QAPGRAHRCA
        70         80         90        100        110        120
HCRRHFPGWV ALWLHTRRCQ ARLPLPCPEC GRRFRHAPFL ALHRQVHAAA TPDLGFACHL
       130        140        150        160        170        180
CGQSFRGWVA LVLHLRAHSA AKRPIACPKC ERRFWRRKQL RAHLRRCHPP APEARPFICG
       190        200        210        220        230        240
NCGRSFAQWD QLVAHKRVHV AEALEEAAAK ALGPRPRGRP AVTAPRPGGD AVDRPFQCAC
       250        260        270        280        290        300
CGKRFRHKPN LIAHRRVHTG ERPHQCPECG KRFTNKPYLT SHRRIHTGEK PYPCKECGRR
       310        320        330        340        350        360
FRHKPNLLSH SKIHKRSEGS AQAAPGPGSP QLPAGPQESA AEPTPAVPLK PAQEPPPGAP
       370        380        390        400        410        420
PEHPQDPIEA PPSLYSCDDC GRSFRLERFL RAHQRQHTGE RPFTCAECGK NFGKKTHLVA
       430        440        450        460        470        480
HSRVHSGERP FACEECGRRF SQGSHLAAHR RDHAPDRPFV CPDCGKAFRH KPYLAAHRRI
       490        500        510        520        530        540
HTGEKPYVCP DCGKAFSQKS NLVSHRRIHT GERPYACPDC DRSFSQKSNL ITHRKSHIRD
       550        560
GAFCCAICGQ TFDDEERLLA HQKKHDV

Isoforms

- Isoform 2 of Replication initiator 1

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9BWE0-1-unknown	MLERRC...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9BWE0-1-unknown	MLERRC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110011
Q9BWE0-21-unknown	SGPSQE...	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14969
Q9BWE0-21-unknown	SGPSQE...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141183

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QPRLLS	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14969
...KRPIAC	146	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428562
...KRPIAC	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113983
...HKPNLL	307	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419789
...HKPNLL	307	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113985
...SPQLPA	333	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419872
...SPQLPA	333	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt113987
...KKHDV	567	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KKHDV	567	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82903

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	20	RLLS.\|.SGPS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)