Q9BWT3: Poly(A) polymerase gamma

General Information

Protein names	- Poly(A) polymerase gamma - PAP-gamma - 2.7.7.19 - Neo-poly(A) polymerase - Neo-PAP - Polynucleotide adenylyltransferase gamma - SRP RNA 3'-adenylating enzyme - Signal recognition particle RNA-adenylating enzyme - SRP RNA-adenylating enzyme
Gene names	PAPOLG
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BWT3

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKEMSANTVL DSQRQQKHYG ITSPISLASP KEIDHIYTQK LIDAMKPFGV FEDEEELNHR
        70         80         90        100        110        120
LVVLGKLNNL VKEWISDVSE SKNLPPSVVA TVGGKIFTFG SYRLGVHTKG ADIDALCVAP
       130        140        150        160        170        180
RHVERSDFFQ SFFEKLKHQD GIRNLRAVED AFVPVIKFEF DGIEIDLVFA RLAIQTISDN
       190        200        210        220        230        240
LDLRDDSRLR SLDIRCIRSL NGCRVTDEIL HLVPNKETFR LTLRAVKLWA KRRGIYSNML
       250        260        270        280        290        300
GFLGGVSWAM LVARTCQLYP NAAASTLVHK FFLVFSKWEW PNPVLLKQPE ESNLNLPVWD
       310        320        330        340        350        360
PRVNPSDRYH LMPIITPAYP QQNSTYNVST STRTVMVEEF KQGLAVTDEI LQGKSDWSKL
       370        380        390        400        410        420
LEPPNFFQKY RHYIVLTASA STEENHLEWV GLVESKIRVL VGNLERNEFI TLAHVNPQSF
       430        440        450        460        470        480
PGNKEHHKDN NYVSMWFLGI IFRRVENAES VNIDLTYDIQ SFTDTVYRQA NNINMLKEGM
       490        500        510        520        530        540
KIEATHVKKK QLHHYLPAEI LQKKKKQSLS DVNRSSGGLQ SKRLSLDSSC LDSSRDTDNG
       550        560        570        580        590        600
TPFNSPASKS DSPSVGETER NSAEPAAVIV EKPLSVPPAQ GLSIPVIGAK VDSTVKTVSP
       610        620        630        640        650        660
PTVCTIPTVV GRNVIPRITT PHNPAQGQPH LNGMSNITKT VTPKRSHSPS IDGTPKRLKD
       670        680        690        700        710        720
VEKFIRLEST FKDPRTAEER KRKSVDAIGG ESMPIPTIDT SRKKRLPSKE LPDSSSPVPA
       730
NNIRVIKNSI RLTLNR

Isoforms

- Isoform 2 of Poly(A) polymerase gamma

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BWT3-1-unknown	MKEMSA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BWT3-1-unknown	MKEMSA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84252
Q9BWT3-1-unknown	MKEMSA...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9BWT3-1-unknown	MKEMSA...	1		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BWT3-333-unknown	RTVMVE...	333	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000405570
Q9BWT3-333-unknown	RTVMVE...	333	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130888
Q9BWT3-692-unknown	SMPIPT...	692	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13241
Q9BWT3-692-unknown	SMPIPT...	692	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt200159

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AIGGES	691	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13241
...LTLNR	736	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LTLNR	736	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79870

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	691	GGES.\|.SMPI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)