Q9BYI3: Hyccin {ECO:0000303|PubMed:16951682}

General Information

Protein names	- Hyccin {ECO:0000303\|PubMed:16951682} - Down-regulated by CTNNB1 protein A {ECO:0000303\|PubMed:10910037} - Protein FAM126A {ECO:0000305}
Gene names	FAM126A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BYI3

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Hyccin - Isoform 3 of Hyccin

Sequence View

        10         20         30         40         50         60
MFTSEKGVVE EWLSEFKTLP ETSLPNYATN LKDKSSLVSS LYKVIQEPQS ELLEPVCHQL
        70         80         90        100        110        120
FEFYRSGEEQ LLQFTLQFLP ELIWCYLAVS ASRNVHSSGC IEALLLGVYN LEIVDKQGHT
       130        140        150        160        170        180
KVLSFTIPSL SKPSVYHEPS SIGSMALTES ALSQHGLSKV VYSGPHPQRE MLTAQNRFEV
       190        200        210        220        230        240
LTFLLLCYNA ALTYMPSVSL QSLCQICSRI CVCGYPRQHV RKYKGISSRI PVSSGFMVQM
       250        260        270        280        290        300
LTGIYFAFYN GEWDLAQKAL DDIIYRAQLE LYPEPLLVAN AIKASLPHGP MKSNKEGTRC
       310        320        330        340        350        360
IQVEITPTSS RISRNAVTSM SIRGHRWKRH GNTELTGQEE LMEISEVDEG FYSRAASSTS
       370        380        390        400        410        420
QSGLSNSSHN CSNKPSIGKN HRRSGGSKTG GKEKETTGES CKDHFARKQT QRAQSENLEL
       430        440        450        460        470        480
LSLKRLTLTT SQSLPKPSSH GLAKTAATVF SKSFEQVSGV TVPHNPSSAV GCGAGTDANR
       490        500        510        520
FSACSLQEEK LIYVSERTEL PMKHQSGQQR PPSISITLST D         10         20         30         40         50         60
MFTSEKGVVE EWLSEFKTLP ETSLPNYATN LKDKSSLVSS LYKVIQEPQS ELLEPVCHQL
        70         80         90        100        110        120
FEFYRSGEEQ LLQFTLQFLP ELIWCYLAVS ASRNVHSSGC IEALLLGVYN LEIVDKQGHT
       130        140        150        160        170        180
KVLSFTIPSL SKPSVYHEPS SIGSMALTES ALSQHGLSKV VYSGPHPQRE MLTAQNRFEV
       190        200        210        220        230        240
LTFLLLCYNA ALTYMPSVSL QSLCQICSRI CVCGYPRQHV RKYKGISSRI PVSSGFMVQM
       250        260        270        280        290        300
LTGIYFAFYN GEWDLAQKAL DDIIYRAQLE LYPEPLLVAN AIKASLPHGP MKSNKEGTRC
       310        320        330        340        350        360
IQVEITPTSS RISRNAVTSM SIRGHRWKRH GNTELTGQEE LMEISEVDEG FYSRAASSTS
       370        380        390        400        410        420
QSGLSNSSHN CSNKPSIGKN HRRSGGSKTG GKEKETTGES CKDHFARKQT QRAQSENLEL
       430        440        450        460        470        480
LSLKRLTLTT SQSLPKPSSH GLAKTAATVF SKSFEQVSGV TVPHNPSSAV GCGAGTDANR
       490        500        510        520
FSACSLQEEK LIYVSERTEL PMKHQSGQQR PPSISITLST D

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BYI3-1-unknown	MFTSEK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BYI3-1-	MFTSEK...	1		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9BYI3-342-unknown	MEISEV...	342	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77381
Q9BYI3-365-unknown	SNSSHN...	365	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14974
Q9BYI3-365-unknown	SNSSHN...	365	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137133

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SQSGLS	364	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14974
...SQSGLS	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120025
...TLSTD	521	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TLSTD	521	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72999

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	364	SGLS.\|.SNSS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)