Q9GZR2: RNA exonuclease 4

General Information

Protein names	- RNA exonuclease 4 - 3.1.-.- - Exonuclease XPMC2 - Prevents mitotic catastrophe 2 protein homolog - hPMC2
Gene names	REXO4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9GZR2

6 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGKAKVPASK RAPSSPVAKP GPVKTLTRKK NKKKKRFWKS KAREVSKKPA SGPGAVVRPP
        70         80         90        100        110        120
KAPEDFSQNW KALQEWLLKQ KSQAPEKPLV ISQMGSKKKP KIIQQNKKET SPQVKGEEMP
       130        140        150        160        170        180
AGKDQEASRG SVPSGSKMDR RAPVPRTKAS GTEHNKKGTK ERTNGDIVPE RGDIEHKKRK
       190        200        210        220        230        240
AKEAAPAPPT EEDIWFDDVD PADIEAAIGP EAAKIARKQL GQSEGSVSLS LVKEQAFGGL
       250        260        270        280        290        300
TRALALDCEM VGVGPKGEES MAARVSIVNQ YGKCVYDKYV KPTEPVTDYR TAVSGIRPEN
       310        320        330        340        350        360
LKQGEELEVV QKEVAEMLKG RILVGHALHN DLKVLFLDHP KKKIRDTQKY KPFKSQVKSG
       370        380        390        400        410        420
RPSLRLLSEK ILGLQVQQAE HCSIQDAQAA MRLYVMVKKE WESMARDRRP LLTAPDHCSD

DA

Isoforms

- Isoform 2 of RNA exonuclease 4

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9GZR2-1-unknown	MGKAKV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9GZR2-1-unknown	MGKAKV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87321
Q9GZR2-2-unknown	GKAKVP...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9GZR2-2-unknown	GKAKVP...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9GZR2-2-unknown	GKAKVP...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162938
Q9GZR2-16-unknown	PVAKPG...	16	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000457846
Q9GZR2-16-unknown	PVAKPG...	16	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195059
Q9GZR2-94-unknown	MGSKKK...	94	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000454220
Q9GZR2-94-unknown	MGSKKK...	94	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000391534
Q9GZR2-118-unknown	EMPAGK...	118	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13275
Q9GZR2-194-unknown	IWFDDV...	194	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13276

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QVKGEE	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13275
...PTEEDI	193	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13276
...KYVKPT	282	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000454220
...KYVKPT	282	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391534
...WESMAR	405	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000456823
...WESMAR	405	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000394229
...CSDDA	422	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CSDDA	422	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82939

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	117	KGEE.\|.EMPA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	193	EEDI.\|.IWFD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)