Q9GZS1: DNA-directed RNA polymerase I subunit RPA49

General Information

Protein names	- DNA-directed RNA polymerase I subunit RPA49 - RNA polymerase I subunit A49 - DNA-directed RNA polymerase I subunit E - RNA polymerase I-associated factor 1 - RNA polymerase I-associated factor 53
Gene names	POLR1E
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9GZS1

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of DNA-directed RNA polymerase I subunit RPA49 - Isoform 1 of DNA-directed RNA polymerase I subunit RPA49

Sequence View

        10         20         30         40         50         60
MAAEVLPSAR WQYCGAPDGS QRAVLVQFSN GKLQSPGNMR FTLYENKDST NPRKRNQRIL
        70         80         90        100        110        120
AAETDRLSYV GNNFGTGALK CNTLCRHFVG ILNKTSGQME VYDAELFNMQ PLFSDVSVES
       130        140        150        160        170        180
ELALESQTKT YREKMDSCIE AFGTTKQKRA LNTRRMNRVG NESLNRAVAK AAETIIDTKG
       190        200        210        220        230        240
VTALVSDAIH NDLQDDSLYL PPCYDDAAKP EDVYKFEDLL SPAEYEALQS PSEAFRNVTS
       250        260        270        280        290        300
EEILKMIEEN SHCTFVIEAL KSLPSDVESR DRQARCIWFL DTLIKFRAHR VVKRKSALGP
       310        320        330        340        350        360
GVPHIINTKL LKHFTCLTYN NGRLRNLISD SMKAKITAYV IILALHIHDF QIDLTVLQRD
       370        380        390        400        410
LKLSEKRMME IAKAMRLKIS KRRVSVAAGS EEDHKLGTLS LPLPPAQTSD RLAKRRKIT         10         20         30         40         50         60
MAAEVLPSAR WQYCGAPDGS QRAVLVQFSN GKLQSPGNMR FTLYENKDST NPRKRNQRIL
        70         80         90        100        110        120
AAETDRLSYV GNNFGTGALK CNTLCRHFVG ILNKTSGQME VYDAELFNMQ PLFSDVSVES
       130        140        150        160        170        180
ELALESQTKT YREKMDSCIE AFGTTKQKRA LNTRRMNRVG NESLNRAVAK AAETIIDTKG
       190        200        210        220        230        240
VTALVSDAIH NDLQDDSLYL PPCYDDAAKP EDVYKFEDLL SPAEYEALQS PSEAFRNVTS
       250        260        270        280        290        300
EEILKMIEEN SHCTFVIEAL KSLPSDVESR DRQARCIWFL DTLIKFRAHR VVKRKSALGP
       310        320        330        340        350        360
GVPHIINTKL LKHFTCLTYN NGRLRNLISD SMKAKITAYV IILALHIHDF QIDLTVLQRD
       370        380        390        400        410
LKLSEKRMME IAKAMRLKIS KRRVSVAAGS EEDHKLGTLS LPLPPAQTSD RLAKRRKIT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9GZS1-1-unknown	MAAEVL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9GZS1-1-unknown	MAAEVL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88103
Q9GZS1-185-unknown	VSDAIH...	185	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13283
Q9GZS1-185-unknown	VSDAIH...	185	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143625
Q9GZS1-233-unknown	EAFRNV...	233		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9GZS1-233-unknown	EAFRNV...	233	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160180
Q9GZS1-233-	EAFRNV...	233		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVTALV	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13283
...GVTALV	184	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126867
...	481	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...	481	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83721

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	184	TALV.\|.VSDA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)