Q9H0D6: 5'-3' exoribonuclease 2

General Information

Protein names	- 5'-3' exoribonuclease 2 - 3.1.13.- - DHM1-like protein - DHP protein
Gene names	XRN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H0D6

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGVPAFFRWL SRKYPSIIVN CVEEKPKECN GVKIPVDASK PNPNDVEFDN LYLDMNGIIH
        70         80         90        100        110        120
PCTHPEDKPA PKNEDEMMVA IFEYIDRLFS IVRPRRLLYM AIDGVAPRAK MNQQRSRRFR
       130        140        150        160        170        180
ASKEGMEAAV EKQRVREEIL AKGGFLPPEE IKERFDSNCI TPGTEFMDNL AKCLRYYIAD
       190        200        210        220        230        240
RLNNDPGWKN LTVILSDASA PGEGEHKIMD YIRRQRAQPN HDPNTHHCLC GADADLIMLG
       250        260        270        280        290        300
LATHEPNFTI IREEFKPNKP KPCGLCNQFG HEVKDCEGLP REKKGKHDEL ADSLPCAEGE
       310        320        330        340        350        360
FIFLRLNVLR EYLERELTMA SLPFTFDVER SIDDWVFMCF FVGNDFLPHL PSLEIRENAI
       370        380        390        400        410        420
DRLVNIYKNV VHKTGGYLTE SGYVNLQRVQ MIMLAVGEVE DSIFKKRKDD EDSFRRRQKE
       430        440        450        460        470        480
KRKRMKRDQP AFTPSGILTP HALGSRNSPG SQVASNPRQA AYEMRMQNNS SPSISPNTSF
       490        500        510        520        530        540
TSDGSPSPLG GIKRKAEDSD SEPEPEDNVR LWEAGWKQRY YKNKFDVDAA DEKFRRKVVQ
       550        560        570        580        590        600
SYVEGLCWVL RYYYQGCASW KWYYPFHYAP FASDFEGIAD MPSDFEKGTK PFKPLEQLMG
       610        620        630        640        650        660
VFPAASGNFL PPSWRKLMSD PDSSIIDFYP EDFAIDLNGK KYAWQGVALL PFVDERRLRA
       670        680        690        700        710        720
ALEEVYPDLT PEETRRNSLG GDVLFVGKHH PLHDFILELY QTGSTEPVEV PPELCHGIQG
       730        740        750        760        770        780
KFSLDEEAIL PDQIVCSPVP MLRDLTQNTV VSINFKDPQF AEDYIFKAVM LPGARKPAAV
       790        800        810        820        830        840
LKPSDWEKSS NGRQWKPQLG FNRDRRPVHL DQAAFRTLGH VMPRGSGTGI YSNAAPPPVT
       850        860        870        880        890        900
YQGNLYRPLL RGQAQIPKLM SNMRPQDSWR GPPPLFQQQR FDRGVGAEPL LPWNRMLQTQ
       910        920        930        940        950
NAAFQPNQYQ MLAGPGGYPP RRDDRGGRQG YPREGRKYPL PPPSGRYNWN

Isoforms

- Isoform 2 of 5'-3' exoribonuclease 2

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H0D6-1-unknown	MGVPAF...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H0D6-2-unknown	GVPAFF...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H0D6-77-unknown	MMVAIF...	77	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94752
Q9H0D6-473-unknown	SISPNT...	473	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167924
Q9H0D6-473-	SISPNT...	473		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9H0D6-473-	SISPNT...	473		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9H0D6-478-unknown	TSFTSD...	478	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13285
Q9H0D6-478-unknown	TSFTSD...	478	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152032
Q9H0D6-484-unknown	GSPSPL...	484		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9H0D6-484-unknown	GSPSPL...	484	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162302

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SISPNT	477	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13285
...SISPNT	477	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135442
...RYNWN	950	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RYNWN	950	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90370

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	477	SPNT.\|.TSFT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)