Q9H1J1: Regulator of nonsense transcripts 3A

General Information

Protein names	- Regulator of nonsense transcripts 3A - Nonsense mRNA reducing factor 3A - Up-frameshift suppressor 3 homolog A - hUpf3
Gene names	UPF3A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H1J1

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Regulator of nonsense transcripts 3A - Isoform 3 of Regulator of nonsense transcripts 3A

Sequence View

        10         20         30         40         50         60
MRSEKEGAGG LRAAVAARGP SGREKLSALE VQFHRDSQQQ EAETPPTSSS GCGGGAGKPR
        70         80         90        100        110        120
EEKRTALSKV VIRRLPPGLT KEQLEEQLRP LPAHDYFEFF AADLSLYPHL YSRAYINFRN
       130        140        150        160        170        180
PDDILLFRDR FDGYIFLDSK GLEYPAVVEF APFQKIAKKK LRKKDAKTGS IEDDPEYKKF
       190        200        210        220        230        240
LETYCVEEEK TSANPETLLG EMEAKTRELI ARRTTPLLEY IKNRKLEKQR IREEKREERR
       250        260        270        280        290        300
RRELEKKRLR EEEKRRRREE ERCKKKETDK QKKIAEKEVR IKLLKKPEKG EEPTTEKPKE
       310        320        330        340        350        360
RGEEIDTGGG KQESCAPGAV VKARPMEGSL EEPQETSHSG SDKEHRDVER SQEQESEAQR
       370        380        390        400        410        420
YHVDDGRRHR AHHEPERLSR RSEDEQRWGK GPGQDRGKKG SQDSGAPGEA MERLGRAQRC
       430        440        450        460        470
DDSPAPRKER LANKDRPALQ LYDPGARFRA RECGGNRRIC KAEGSGTGPE KREEAE         10         20         30         40         50         60
MRSEKEGAGG LRAAVAARGP SGREKLSALE VQFHRDSQQQ EAETPPTSSS GCGGGAGKPR
        70         80         90        100        110        120
EEKRTALSKV VIRRLPPGLT KEQLEEQLRP LPAHDYFEFF AADLSLYPHL YSRAYINFRN
       130        140        150        160        170        180
PDDILLFRDR FDGYIFLDSK GLEYPAVVEF APFQKIAKKK LRKKDAKTGS IEDDPEYKKF
       190        200        210        220        230        240
LETYCVEEEK TSANPETLLG EMEAKTRELI ARRTTPLLEY IKNRKLEKQR IREEKREERR
       250        260        270        280        290        300
RRELEKKRLR EEEKRRRREE ERCKKKETDK QKKIAEKEVR IKLLKKPEKG EEPTTEKPKE
       310        320        330        340        350        360
RGEEIDTGGG KQESCAPGAV VKARPMEGSL EEPQETSHSG SDKEHRDVER SQEQESEAQR
       370        380        390        400        410        420
YHVDDGRRHR AHHEPERLSR RSEDEQRWGK GPGQDRGKKG SQDSGAPGEA MERLGRAQRC
       430        440        450        460        470
DDSPAPRKER LANKDRPALQ LYDPGARFRA RECGGNRRIC KAEGSGTGPE KREEAE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9H1J1-1-unknown	MRSEKE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H1J1-1-unknown	MRSEKE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt87275
Q9H1J1-68-unknown	SKVVIR...	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14991
Q9H1J1-68-unknown	SKVVIR...	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140503
Q9H1J1-326-unknown	MEGSLE...	326	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt87276
Q9H1J1-326-unknown	MEGSLE...	326	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt108977

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KRTALS	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14991
...KRTALS	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123630
...REEAE	476	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...REEAE	476	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82894
...REEAE	476	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82893

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	67	TALS.\|.SKVV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)