Q9H6W3: Ribosomal oxygenase 1 {ECO:0000312|HGNC:HGNC:20968}

General Information

Protein names	- Ribosomal oxygenase 1 {ECO:0000312\|HGNC:HGNC:20968} - 60S ribosomal protein L8 histidine hydroxylase - Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 - 1.14.11.- - 1.14.11.27 {ECO:0000269\|PubMed:23103944} - Histone lysine demethylase NO66 - Myc-associated protein with JmjC domain - Nucleolar protein 66 - hsNO66 - Ribosomal oxygenase NO66 - ROX
Gene names	NO66
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H6W3

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 - Isoform 2 of Ribosomal oxygenase 1

Sequence View

        10         20         30         40         50         60
MDGLQASAGP LRRGRPKRRR KPQPHSGSVL ALPLRSRKIR KQLRSVVSRM AALRTQTLPS
        70         80         90        100        110        120
ENSEESRVES TADDLGDALP GGAAVAAVPD AARREPYGHL GPAELLEASP AARSLQTPSA
       130        140        150        160        170        180
RLVPASAPPA RLVEVPAAPV RVVETSALLC TAQHLAAVQS SGAPATASGP QVDNTGGEPA
       190        200        210        220        230        240
WDSPLRRVLA ELNRIPSSRR RAARLFEWLI APMPPDHFYR RLWEREAVLV RRQDHTYYQG
       250        260        270        280        290        300
LFSTADLDSM LRNEEVQFGQ HLDAARYING RRETLNPPGR ALPAAAWSLY QAGCSLRLLC
       310        320        330        340        350        360
PQAFSTTVWQ FLAVLQEQFG SMAGSNVYLT PPNSQGFAPH YDDIEAFVLQ LEGRKLWRVY
       370        380        390        400        410        420
RPRVPTEELA LTSSPNFSQD DLGEPVLQTV LEPGDLLYFP RGFIHQAECQ DGVHSLHLTL
       430        440        450        460        470        480
STYQRNTWGD FLEAILPLAV QAAMEENVEF RRGLPRDFMD YMGAQHSDSK DPRRTAFMEK
       490        500        510        520        530        540
VRVLVARLGH FAPVDAVADQ RAKDFIHDSL PPVLTDRERA LSVYGLPIRW EAGEPVNVGA
       550        560        570        580        590        600
QLTTETEVHM LQDGIARLVG EGGHLFLYYT VENSRVYHLE EPKCLEIYPQ QADAMELLLG
       610        620        630        640
SYPEFVRVGD LPCDSVEDQL SLATTLYDKG LLLTKMPLAL N         10         20         30         40         50         60
MDGLQASAGP LRRGRPKRRR KPQPHSGSVL ALPLRSRKIR KQLRSVVSRM AALRTQTLPS
        70         80         90        100        110        120
ENSEESRVES TADDLGDALP GGAAVAAVPD AARREPYGHL GPAELLEASP AARSLQTPSA
       130        140        150        160        170        180
RLVPASAPPA RLVEVPAAPV RVVETSALLC TAQHLAAVQS SGAPATASGP QVDNTGGEPA
       190        200        210        220        230        240
WDSPLRRVLA ELNRIPSSRR RAARLFEWLI APMPPDHFYR RLWEREAVLV RRQDHTYYQG
       250        260        270        280        290        300
LFSTADLDSM LRNEEVQFGQ HLDAARYING RRETLNPPGR ALPAAAWSLY QAGCSLRLLC
       310        320        330        340        350        360
PQAFSTTVWQ FLAVLQEQFG SMAGSNVYLT PPNSQGFAPH YDDIEAFVLQ LEGRKLWRVY
       370        380        390        400        410        420
RPRVPTEELA LTSSPNFSQD DLGEPVLQTV LEPGDLLYFP RGFIHQAECQ DGVHSLHLTL
       430        440        450        460        470        480
STYQRNTWGD FLEAILPLAV QAAMEENVEF RRGLPRDFMD YMGAQHSDSK DPRRTAFMEK
       490        500        510        520        530        540
VRVLVARLGH FAPVDAVADQ RAKDFIHDSL PPVLTDRERA LSVYGLPIRW EAGEPVNVGA
       550        560        570        580        590        600
QLTTETEVHM LQDGIARLVG EGGHLFLYYT VENSRVYHLE EPKCLEIYPQ QADAMELLLG
       610        620        630        640
SYPEFVRVGD LPCDSVEDQL SLATTLYDKG LLLTKMPLAL N

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H6W3-1-Acetylation	MDGLQA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H6W3-1-Acetylation	MDGLQA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9H6W3-1-Acetylation	MDGLQA...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9H6W3-1-Acetylation	MDGLQA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H6W3-78-	ALPGGA...	78			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H6W3-157-	AVQSSG...	157			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9H6W3-160-	SSGAPA...	160			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9H6W3-213-unknown	MPPDHF...	213		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82990

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PLALN	641	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...PLALN	641	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt78608

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)