Q9H9T3: Elongator complex protein 3

General Information

Protein names	- Elongator complex protein 3 - hELP3 - 2.3.1.48
Gene names	ELP3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H9T3

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Elongator complex protein 3 - Isoform 3 of Elongator complex protein 3 - Isoform 4 of Elongator complex protein 3

Sequence View

        10         20         30         40         50         60
MRQKRKGDLS PAELMMLTIG DVIKQLIEAH EQGKDIDLNK VKTKTAAKYG LSAQPRLVDI
        70         80         90        100        110        120
IAAVPPQYRK VLMPKLKAKP IRTASGIAVV AVMCKPHRCP HISFTGNICV YCPGGPDSDF
       130        140        150        160        170        180
EYSTQSYTGY EPTSMRAIRA RYDPFLQTRH RIEQLKQLGH SVDKVEFIVM GGTFMALPEE
       190        200        210        220        230        240
YRDYFIRNLH DALSGHTSNN IYEAVKYSER SLTKCIGITI ETRPDYCMKR HLSDMLTYGC
       250        260        270        280        290        300
TRLEIGVQSV YEDVARDTNR GHTVKAVCES FHLAKDSGFK VVAHMMPDLP NVGLERDIEQ
       310        320        330        340        350        360
FTEFFENPAF RPDGLKLYPT LVIRGTGLYE LWKSGRYKSY SPSDLVELVA RILALVPPWT
       370        380        390        400        410        420
RVYRVQRDIP MPLVSSGVEH GNLRELALAR MKDLGIQCRD VRTREVGIQE IHHKVRPYQV
       430        440        450        460        470        480
ELVRRDYVAN GGWETFLSYE DPDQDILIGL LRLRKCSEET FRFELGGGVS IVRELHVYGS
       490        500        510        520        530        540
VVPVSSRDPT KFQHQGFGML LMEEAERIAR EEHGSGKIAV ISGVGTRNYY RKIGYRLQGP

YMVKMLK         10         20         30         40         50         60
MRQKRKGDLS PAELMMLTIG DVIKQLIEAH EQGKDIDLNK VKTKTAAKYG LSAQPRLVDI
        70         80         90        100        110        120
IAAVPPQYRK VLMPKLKAKP IRTASGIAVV AVMCKPHRCP HISFTGNICV YCPGGPDSDF
       130        140        150        160        170        180
EYSTQSYTGY EPTSMRAIRA RYDPFLQTRH RIEQLKQLGH SVDKVEFIVM GGTFMALPEE
       190        200        210        220        230        240
YRDYFIRNLH DALSGHTSNN IYEAVKYSER SLTKCIGITI ETRPDYCMKR HLSDMLTYGC
       250        260        270        280        290        300
TRLEIGVQSV YEDVARDTNR GHTVKAVCES FHLAKDSGFK VVAHMMPDLP NVGLERDIEQ
       310        320        330        340        350        360
FTEFFENPAF RPDGLKLYPT LVIRGTGLYE LWKSGRYKSY SPSDLVELVA RILALVPPWT
       370        380        390        400        410        420
RVYRVQRDIP MPLVSSGVEH GNLRELALAR MKDLGIQCRD VRTREVGIQE IHHKVRPYQV
       430        440        450        460        470        480
ELVRRDYVAN GGWETFLSYE DPDQDILIGL LRLRKCSEET FRFELGGGVS IVRELHVYGS
       490        500        510        520        530        540
VVPVSSRDPT KFQHQGFGML LMEEAERIAR EEHGSGKIAV ISGVGTRNYY RKIGYRLQGP

YMVKMLK         10         20         30         40         50         60
MRQKRKGDLS PAELMMLTIG DVIKQLIEAH EQGKDIDLNK VKTKTAAKYG LSAQPRLVDI
        70         80         90        100        110        120
IAAVPPQYRK VLMPKLKAKP IRTASGIAVV AVMCKPHRCP HISFTGNICV YCPGGPDSDF
       130        140        150        160        170        180
EYSTQSYTGY EPTSMRAIRA RYDPFLQTRH RIEQLKQLGH SVDKVEFIVM GGTFMALPEE
       190        200        210        220        230        240
YRDYFIRNLH DALSGHTSNN IYEAVKYSER SLTKCIGITI ETRPDYCMKR HLSDMLTYGC
       250        260        270        280        290        300
TRLEIGVQSV YEDVARDTNR GHTVKAVCES FHLAKDSGFK VVAHMMPDLP NVGLERDIEQ
       310        320        330        340        350        360
FTEFFENPAF RPDGLKLYPT LVIRGTGLYE LWKSGRYKSY SPSDLVELVA RILALVPPWT
       370        380        390        400        410        420
RVYRVQRDIP MPLVSSGVEH GNLRELALAR MKDLGIQCRD VRTREVGIQE IHHKVRPYQV
       430        440        450        460        470        480
ELVRRDYVAN GGWETFLSYE DPDQDILIGL LRLRKCSEET FRFELGGGVS IVRELHVYGS
       490        500        510        520        530        540
VVPVSSRDPT KFQHQGFGML LMEEAERIAR EEHGSGKIAV ISGVGTRNYY RKIGYRLQGP

YMVKMLK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9H9T3-1-unknown	MRQKRK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H9T3-15-unknown	MMLTIG...	15	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73842
Q9H9T3-375-unknown	SSGVEH...	375	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4256
Q9H9T3-375-unknown	SSGVEH...	375	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151211

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PMPLVS	374	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4256
...PMPLVS	374	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134613
...VKMLK	547		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VKMLK	547	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VKMLK	547	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt69460
...VKMLK	547		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	374	PLVS.\|.SSGV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)