Q9HAP2: MLX-interacting protein

General Information

Protein names	- MLX-interacting protein - Class E basic helix-loop-helix protein 36 - bHLHe36 - Transcriptional activator MondoA
Gene names	MLXIP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9HAP2

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of MLX-interacting protein - Isoform 3 of MLX-interacting protein - Isoform 4 of MLX-interacting protein - Isoform 5 of MLX-interacting protein

Sequence View

        10         20         30         40         50         60
MAADVFMCSP RRPRSRGRQV LLKPQVSEDD DDSDTDEPSP PPASGAATPA RAHASAAPPP
        70         80         90        100        110        120
PRAGPGREEP PRRQQIIHSG HFMVSSPHRE HPPKKGYDFD TVNKQTCQTY SFGKTSSCHL
       130        140        150        160        170        180
SIDASLTKLF ECMTLAYSGK LVSPKWKNFK GLKLQWRDKI RLNNAIWRAW YMQYLEKRKN
       190        200        210        220        230        240
PVCHFVTPLD GSVDVDEHRR PEAITTEGKY WKSRIEIVIR EYHKWRTYFK KRLQQHKDED
       250        260        270        280        290        300
LSSLVQDDDM LYWHKHGDGW KTPVPMEEDP LLDTDMLMSE FSDTLFSTLS SHQPVAWPNP
       310        320        330        340        350        360
REIAHLGNAD MIQPGLIPLQ PNLDFMDTFE PFQDLFSSSR SIFGSMLPAS ASAPVPDPNN
       370        380        390        400        410        420
PPAQESILPT TALPTVSLPD SLIAPPTAPS LAHMDEQGCE HTSRTEDPFI QPTDFGPSEP
       430        440        450        460        470        480
PLSVPQPFLP VFTMPLLSPS PAPPPISPVL PLVPPPATAL NPPAPPTFHQ PQKFAGVNKA
       490        500        510        520        530        540
PSVITHTASA TLTHDAPATT FSQSQGLVIT THHPAPSAAP CGLALSPVTR PPQPRLTFVH
       550        560        570        580        590        600
PKPVSLTGGR PKQPHKIVPA PKPEPVSLVL KNARIAPAAF SGQPQAVIMT SGPLKREGML
       610        620        630        640        650        660
ASTVSQSNVV IAPAAIARAP GVPEFHSSIL VTDLGHGTSS PPAPVSRLFP STAQDPLGKG
       670        680        690        700        710        720
EQVPLHGGSP QVTVTGPSRD CPNSGQASPC ASEQSPSPQS PQNNCSGKSD PKNVAALKNR
       730        740        750        760        770        780
QMKHISAEQK RRFNIKMCFD MLNSLISNNS KLTSHAITLQ KTVEYITKLQ QERGQMQEEA
       790        800        810        820        830        840
RRLREEIEEL NATIISCQQL LPATGVPVTR RQFDHMKDMF DEYVKTRTLQ NWKFWIFSII
       850        860        870        880        890        900
IKPLFESFKG MVSTSSLEEL HRTALSWLDQ HCSLPILRPM VLSTLRQLST STSILTDPAQ
       910
LPEQASKAVT RIGKRLGES         10         20         30         40         50         60
MAADVFMCSP RRPRSRGRQV LLKPQVSEDD DDSDTDEPSP PPASGAATPA RAHASAAPPP
        70         80         90        100        110        120
PRAGPGREEP PRRQQIIHSG HFMVSSPHRE HPPKKGYDFD TVNKQTCQTY SFGKTSSCHL
       130        140        150        160        170        180
SIDASLTKLF ECMTLAYSGK LVSPKWKNFK GLKLQWRDKI RLNNAIWRAW YMQYLEKRKN
       190        200        210        220        230        240
PVCHFVTPLD GSVDVDEHRR PEAITTEGKY WKSRIEIVIR EYHKWRTYFK KRLQQHKDED
       250        260        270        280        290        300
LSSLVQDDDM LYWHKHGDGW KTPVPMEEDP LLDTDMLMSE FSDTLFSTLS SHQPVAWPNP
       310        320        330        340        350        360
REIAHLGNAD MIQPGLIPLQ PNLDFMDTFE PFQDLFSSSR SIFGSMLPAS ASAPVPDPNN
       370        380        390        400        410        420
PPAQESILPT TALPTVSLPD SLIAPPTAPS LAHMDEQGCE HTSRTEDPFI QPTDFGPSEP
       430        440        450        460        470        480
PLSVPQPFLP VFTMPLLSPS PAPPPISPVL PLVPPPATAL NPPAPPTFHQ PQKFAGVNKA
       490        500        510        520        530        540
PSVITHTASA TLTHDAPATT FSQSQGLVIT THHPAPSAAP CGLALSPVTR PPQPRLTFVH
       550        560        570        580        590        600
PKPVSLTGGR PKQPHKIVPA PKPEPVSLVL KNARIAPAAF SGQPQAVIMT SGPLKREGML
       610        620        630        640        650        660
ASTVSQSNVV IAPAAIARAP GVPEFHSSIL VTDLGHGTSS PPAPVSRLFP STAQDPLGKG
       670        680        690        700        710        720
EQVPLHGGSP QVTVTGPSRD CPNSGQASPC ASEQSPSPQS PQNNCSGKSD PKNVAALKNR
       730        740        750        760        770        780
QMKHISAEQK RRFNIKMCFD MLNSLISNNS KLTSHAITLQ KTVEYITKLQ QERGQMQEEA
       790        800        810        820        830        840
RRLREEIEEL NATIISCQQL LPATGVPVTR RQFDHMKDMF DEYVKTRTLQ NWKFWIFSII
       850        860        870        880        890        900
IKPLFESFKG MVSTSSLEEL HRTALSWLDQ HCSLPILRPM VLSTLRQLST STSILTDPAQ
       910
LPEQASKAVT RIGKRLGES         10         20         30         40         50         60
MAADVFMCSP RRPRSRGRQV LLKPQVSEDD DDSDTDEPSP PPASGAATPA RAHASAAPPP
        70         80         90        100        110        120
PRAGPGREEP PRRQQIIHSG HFMVSSPHRE HPPKKGYDFD TVNKQTCQTY SFGKTSSCHL
       130        140        150        160        170        180
SIDASLTKLF ECMTLAYSGK LVSPKWKNFK GLKLQWRDKI RLNNAIWRAW YMQYLEKRKN
       190        200        210        220        230        240
PVCHFVTPLD GSVDVDEHRR PEAITTEGKY WKSRIEIVIR EYHKWRTYFK KRLQQHKDED
       250        260        270        280        290        300
LSSLVQDDDM LYWHKHGDGW KTPVPMEEDP LLDTDMLMSE FSDTLFSTLS SHQPVAWPNP
       310        320        330        340        350        360
REIAHLGNAD MIQPGLIPLQ PNLDFMDTFE PFQDLFSSSR SIFGSMLPAS ASAPVPDPNN
       370        380        390        400        410        420
PPAQESILPT TALPTVSLPD SLIAPPTAPS LAHMDEQGCE HTSRTEDPFI QPTDFGPSEP
       430        440        450        460        470        480
PLSVPQPFLP VFTMPLLSPS PAPPPISPVL PLVPPPATAL NPPAPPTFHQ PQKFAGVNKA
       490        500        510        520        530        540
PSVITHTASA TLTHDAPATT FSQSQGLVIT THHPAPSAAP CGLALSPVTR PPQPRLTFVH
       550        560        570        580        590        600
PKPVSLTGGR PKQPHKIVPA PKPEPVSLVL KNARIAPAAF SGQPQAVIMT SGPLKREGML
       610        620        630        640        650        660
ASTVSQSNVV IAPAAIARAP GVPEFHSSIL VTDLGHGTSS PPAPVSRLFP STAQDPLGKG
       670        680        690        700        710        720
EQVPLHGGSP QVTVTGPSRD CPNSGQASPC ASEQSPSPQS PQNNCSGKSD PKNVAALKNR
       730        740        750        760        770        780
QMKHISAEQK RRFNIKMCFD MLNSLISNNS KLTSHAITLQ KTVEYITKLQ QERGQMQEEA
       790        800        810        820        830        840
RRLREEIEEL NATIISCQQL LPATGVPVTR RQFDHMKDMF DEYVKTRTLQ NWKFWIFSII
       850        860        870        880        890        900
IKPLFESFKG MVSTSSLEEL HRTALSWLDQ HCSLPILRPM VLSTLRQLST STSILTDPAQ
       910
LPEQASKAVT RIGKRLGES         10         20         30         40         50         60
MAADVFMCSP RRPRSRGRQV LLKPQVSEDD DDSDTDEPSP PPASGAATPA RAHASAAPPP
        70         80         90        100        110        120
PRAGPGREEP PRRQQIIHSG HFMVSSPHRE HPPKKGYDFD TVNKQTCQTY SFGKTSSCHL
       130        140        150        160        170        180
SIDASLTKLF ECMTLAYSGK LVSPKWKNFK GLKLQWRDKI RLNNAIWRAW YMQYLEKRKN
       190        200        210        220        230        240
PVCHFVTPLD GSVDVDEHRR PEAITTEGKY WKSRIEIVIR EYHKWRTYFK KRLQQHKDED
       250        260        270        280        290        300
LSSLVQDDDM LYWHKHGDGW KTPVPMEEDP LLDTDMLMSE FSDTLFSTLS SHQPVAWPNP
       310        320        330        340        350        360
REIAHLGNAD MIQPGLIPLQ PNLDFMDTFE PFQDLFSSSR SIFGSMLPAS ASAPVPDPNN
       370        380        390        400        410        420
PPAQESILPT TALPTVSLPD SLIAPPTAPS LAHMDEQGCE HTSRTEDPFI QPTDFGPSEP
       430        440        450        460        470        480
PLSVPQPFLP VFTMPLLSPS PAPPPISPVL PLVPPPATAL NPPAPPTFHQ PQKFAGVNKA
       490        500        510        520        530        540
PSVITHTASA TLTHDAPATT FSQSQGLVIT THHPAPSAAP CGLALSPVTR PPQPRLTFVH
       550        560        570        580        590        600
PKPVSLTGGR PKQPHKIVPA PKPEPVSLVL KNARIAPAAF SGQPQAVIMT SGPLKREGML
       610        620        630        640        650        660
ASTVSQSNVV IAPAAIARAP GVPEFHSSIL VTDLGHGTSS PPAPVSRLFP STAQDPLGKG
       670        680        690        700        710        720
EQVPLHGGSP QVTVTGPSRD CPNSGQASPC ASEQSPSPQS PQNNCSGKSD PKNVAALKNR
       730        740        750        760        770        780
QMKHISAEQK RRFNIKMCFD MLNSLISNNS KLTSHAITLQ KTVEYITKLQ QERGQMQEEA
       790        800        810        820        830        840
RRLREEIEEL NATIISCQQL LPATGVPVTR RQFDHMKDMF DEYVKTRTLQ NWKFWIFSII
       850        860        870        880        890        900
IKPLFESFKG MVSTSSLEEL HRTALSWLDQ HCSLPILRPM VLSTLRQLST STSILTDPAQ
       910
LPEQASKAVT RIGKRLGES

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9HAP2-1-unknown	MAADVF...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81262
Q9HAP2-2-unknown	MAADVF...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9HAP2-2-Acetylation	AADVFM...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9HAP2-2-Acetylation	AADVFM...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9HAP2-2-Acetylation	AADVFM...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9HAP2-2-Acetylation	AADVFM...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110646
Q9HAP2-190-unknown	DGSVDV...	190		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15005
Q9HAP2-190-unknown	DGSVDV...	190		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146253
Q9HAP2-394-unknown	MDEQGC...	394		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81261
Q9HAP2-394-unknown	MDEQGC...	394		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81263
Q9HAP2-394-unknown	MDEQGC...	394		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81264
Q9HAP2-394-unknown	MDEQGC...	394		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102081

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FVTPLD	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15005
...FVTPLD	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129557
...RLGES	919	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RLGES	919	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76879

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	189	TPLD.\|.DGSV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)