Q9HC62: Sentrin-specific protease 2

General Information

Protein names	- Sentrin-specific protease 2 - 3.4.22.- - Axam2 - SMT3-specific isopeptidase 2 - Smt3ip2 - Sentrin/SUMO-specific protease SENP2
Gene names	SENP2
Organism	Homo sapiens
Protease Family	C48.007
Protease ID	C48.007
Chromosome location
UniProt ID	Q9HC62

4 N-termini

4 C-termini

1 Cleavages

6 Substrates

Sequence

        10         20         30         40         50         60
MYRWLVRILG TIFRFCDRSV PPARALLKRR RSDSTLFSTV DTDEIPAKRP RLDCFIHQVK
        70         80         90        100        110        120
NSLYNAASLF GFPFQLTTKP MVTSACNGTR NVAPSGEVFS NSSSCELTGS GSWNNMLKLG
       130        140        150        160        170        180
NKSPNGISDY PKIRVTVTRD QPRRVLPSFG FTLNSEGCNR RPGGRRHSKG NPESSLMWKP
       190        200        210        220        230        240
QEQAVTEMIS EESGKGLRRP HCTVEEGVQK EEREKYRKLL ERLKESGHGN SVCPVTSNYH
       250        260        270        280        290        300
SSQRSQMDTL KTKGWGEEQN HGVKTTQFVP KQYRLVETRG PLCSLRSEKR CSKGKITDTE
       310        320        330        340        350        360
TMVGIRFENE SRRGYQLEPD LSEEVSARLR LGSGSNGLLR RKVSIIETKE KNCSGKERDR
       370        380        390        400        410        420
RTDDLLELTE DMEKEISNAL GHGPQDEILS SAFKLRITRG DIQTLKNYHW LNDEVINFYM
       430        440        450        460        470        480
NLLVERNKKQ GYPALHVFST FFYPKLKSGG YQAVKRWTKG VNLFEQEIIL VPIHRKVHWS
       490        500        510        520        530        540
LVVIDLRKKC LKYLDSMGQK GHRICEILLQ YLQDESKTKR NSDLNLLEWT HHSMKPHEIP
       550        560        570        580
QQLNGSDCGM FTCKYADYIS RDKPITFTQH QMPLFRKKMV WEILHQQLL

Isoforms

- Isoform 2 of Sentrin-specific protease 2

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 1 Cleavages - 6 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9HC62-1-unknown	MYRWLV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9HC62-177-unknown	MWKPQE...	177	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000394562
Q9HC62-294-unknown	GKITDT...	294	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399201
Q9HC62-321-unknown	LSEEVS...	321	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13359

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KYRKLL	219	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399156
...QLEPDL	320	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13359
...PHEIPQ	540	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399201
...HQQLL	589	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	320	EPDL.\|.LSEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
SUMO2-Isoform2_HUMAN	69	TGGV.\|.VY	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31577
SUMO1-Isoform2_HUMAN	72	TGGH.\|.HSTV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31579
SUMO3_HUMAN	92	TGGV.\|.VPES	inferred from experiment	unknown	MEROPS	Yasuda H	Nishida T et al.:Characterization of a novel mam... (C48.007)	11489887,
SUMO2_HUMAN	93	TGGV.\|.VY	inferred from experiment	unknown	MEROPS	Yasuda H	Nishida T et al.:Characterization of a novel mam... (C48.007)	11489887,
SUMO1_HUMAN	97	TGGH.\|.HSTV	inferred from experiment	unknown	MEROPS	Yasuda H	Nishida T et al.:Characterization of a novel mam... (C48.007)	11489887,
SUMO3-Isoform2_HUMAN	130	TGGV.\|.VPES	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31575