Q9HDB5: Neurexin-3-beta

General Information

Protein names	- Neurexin-3-beta - Neurexin III-beta - Neurexin-3-beta, soluble form - Neurexin-3-beta, C-terminal fragment - NRXN3-CTF
Gene names	NRXN3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9HDB5

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2b of Neurexin-3-beta - Isoform 3b of Neurexin-3-beta - Isoform 4b of Neurexin-3-beta

Sequence View

        10         20         30         40         50         60
MHLRIHARRS PPRRPAWTLG IWFLFWGCIV SSVWSSSNVA SSSSTSSSPG SHSQHEHHFH
        70         80         90        100        110        120
GSKHHSVPIS IYRSPVSLRG GHAGATYIFG KSGGLILYTW PANDRPSTRS DRLAVGFSTT
       130        140        150        160        170        180
VKDGILVRID SAPGLGDFLQ LHIEQGKIGV VFNIGTVDIS IKEERTPVND GKYHVVRFTR
       190        200        210        220        230        240
NGGNATLQVD NWPVNEHYPT GRQLTIFNTQ AQIAIGGKDK GRLFQGQLSG LYYDGLKVLN
       250        260        270        280        290        300
MAAENNPNIK INGSVRLVGE VPSILGTTQT TSMPPEMSTT VMETTTTMAT TTTRKNRSTA
       310        320        330        340        350        360
SIQPTSDDLV SSAECSSDDE DFVECEPSTG GELVIPLLVE DPLATPPIAT RAPSITLPPT
       370        380        390        400        410        420
FRPLLTIIET TKDSLSMTSE AGLPCLSDQG SDGCDDDGLV ISGYGSGETF DSNLPPTDDE
       430        440        450        460        470        480
DFYTTFSLVT DKSLSTSIFE GGYKAHAPKW ESKDFRPNKV SETSRTTTTS LSPELIRFTA
       490        500        510        520        530        540
SSSSGMVPKL PAGKMNNRDL KPQPDIVLLP LPTAYELDST KLKSPLITSP MFRNVPTANP
       550        560        570        580        590        600
TEPGIRRVPG ASEVIRESSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYQVDETR
       610        620        630
NYISNSAQSN GTLMKEKQQS SKSGHKKQKN KDREYYV         10         20         30         40         50         60
MHLRIHARRS PPRRPAWTLG IWFLFWGCIV SSVWSSSNVA SSSSTSSSPG SHSQHEHHFH
        70         80         90        100        110        120
GSKHHSVPIS IYRSPVSLRG GHAGATYIFG KSGGLILYTW PANDRPSTRS DRLAVGFSTT
       130        140        150        160        170        180
VKDGILVRID SAPGLGDFLQ LHIEQGKIGV VFNIGTVDIS IKEERTPVND GKYHVVRFTR
       190        200        210        220        230        240
NGGNATLQVD NWPVNEHYPT GRQLTIFNTQ AQIAIGGKDK GRLFQGQLSG LYYDGLKVLN
       250        260        270        280        290        300
MAAENNPNIK INGSVRLVGE VPSILGTTQT TSMPPEMSTT VMETTTTMAT TTTRKNRSTA
       310        320        330        340        350        360
SIQPTSDDLV SSAECSSDDE DFVECEPSTG GELVIPLLVE DPLATPPIAT RAPSITLPPT
       370        380        390        400        410        420
FRPLLTIIET TKDSLSMTSE AGLPCLSDQG SDGCDDDGLV ISGYGSGETF DSNLPPTDDE
       430        440        450        460        470        480
DFYTTFSLVT DKSLSTSIFE GGYKAHAPKW ESKDFRPNKV SETSRTTTTS LSPELIRFTA
       490        500        510        520        530        540
SSSSGMVPKL PAGKMNNRDL KPQPDIVLLP LPTAYELDST KLKSPLITSP MFRNVPTANP
       550        560        570        580        590        600
TEPGIRRVPG ASEVIRESSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYQVDETR
       610        620        630
NYISNSAQSN GTLMKEKQQS SKSGHKKQKN KDREYYV         10         20         30         40         50         60
MHLRIHARRS PPRRPAWTLG IWFLFWGCIV SSVWSSSNVA SSSSTSSSPG SHSQHEHHFH
        70         80         90        100        110        120
GSKHHSVPIS IYRSPVSLRG GHAGATYIFG KSGGLILYTW PANDRPSTRS DRLAVGFSTT
       130        140        150        160        170        180
VKDGILVRID SAPGLGDFLQ LHIEQGKIGV VFNIGTVDIS IKEERTPVND GKYHVVRFTR
       190        200        210        220        230        240
NGGNATLQVD NWPVNEHYPT GRQLTIFNTQ AQIAIGGKDK GRLFQGQLSG LYYDGLKVLN
       250        260        270        280        290        300
MAAENNPNIK INGSVRLVGE VPSILGTTQT TSMPPEMSTT VMETTTTMAT TTTRKNRSTA
       310        320        330        340        350        360
SIQPTSDDLV SSAECSSDDE DFVECEPSTG GELVIPLLVE DPLATPPIAT RAPSITLPPT
       370        380        390        400        410        420
FRPLLTIIET TKDSLSMTSE AGLPCLSDQG SDGCDDDGLV ISGYGSGETF DSNLPPTDDE
       430        440        450        460        470        480
DFYTTFSLVT DKSLSTSIFE GGYKAHAPKW ESKDFRPNKV SETSRTTTTS LSPELIRFTA
       490        500        510        520        530        540
SSSSGMVPKL PAGKMNNRDL KPQPDIVLLP LPTAYELDST KLKSPLITSP MFRNVPTANP
       550        560        570        580        590        600
TEPGIRRVPG ASEVIRESSS TTGMVVGIVA AAALCILILL YAMYKYRNRD EGSYQVDETR
       610        620        630
NYISNSAQSN GTLMKEKQQS SKSGHKKQKN KDREYYV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9HDB5-1-unknown	MHLRIH...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83322
Q9HDB5-1-unknown	MHLRIH...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83323
Q9HDB5-1-unknown	MHLRIH...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83324
Q9HDB5-36-unknown	SSNVAS...	36	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9HDB5-36-unknown	SSNVAS...	36	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9HDB5-36-unknown	SSNVAS...	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115272
Q9HDB5-36-unknown	SSNVAS...	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115273
Q9HDB5-36-unknown	SSNVAS...	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115274
Q9HDB5-466-unknown	TTTTSL...	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18128
Q9HDB5-551-unknown	ASEVIR...	551	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9HDB5-551-unknown	ASEVIR...	551	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116237
Q9HDB5-551-unknown	ASEVIR...	551	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116236

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SETSRT	465	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18128
...RRVPGA	550	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...REYYV	637	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...REYYV	637	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78940
...REYYV	637	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78942

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	465	TSRT.\|.TTTT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)