Q9NPF4: Probable tRNA N6-adenosine threonylcarbamoyltransferase {ECO:0000255|HAMAP-Rule:MF_03180}

General Information

Protein names	- Probable tRNA N6-adenosine threonylcarbamoyltransferase {ECO:0000255\|HAMAP-Rule:MF_03180} - 2.3.1.234 {ECO:0000255\|HAMAP-Rule:MF_03180} - N6-L-threonylcarbamoyladenine synthase - t(6)A synthase - O-sialoglycoprotein endopeptidase {ECO:0000255\|HAMAP-Rule:MF_03180} - hOSGEP {ECO:0000303\|PubMed:12039036} - t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP {ECO:0000255\|HAMAP-Rule:MF_03180} - tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP {ECO:0000255\|HAMAP-Rule:MF_03180}
Gene names	OSGEP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NPF4

5 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPAVLGFEGS ANKIGVGVVR DGKVLANPRR TYVTPPGTGF LPGDTARHHR AVILDLLQEA
        70         80         90        100        110        120
LTESGLTSQD IDCIAYTKGP GMGAPLVSVA VVARTVAQLW NKPLVGVNHC IGHIEMGRLI
       130        140        150        160        170        180
TGATSPTVLY VSGGNTQVIA YSEHRYRIFG ETIDIAVGNC LDRFARVLKI SNDPSPGYNI
       190        200        210        220        230        240
EQMAKRGKKL VELPYTVKGM DVSFSGILSF IEDVAHRMLA TGECTPEDLC FSLQETVFAM
       250        260        270        280        290        300
LVEITERAMA HCGSQEALIV GGVGCNVRLQ EMMATMCQER GARLFATDER FCIDNGAMIA
       310        320        330
QAGWEMFRAG HRTPLSDSGV TQRYRTDEVE VTWRD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NPF4-1-unknown	MPAVLG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NPF4-2-unknown	PAVLGF...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NPF4-2-unknown	PAVLGF...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NPF4-183-unknown	MAKRGK...	183	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451548
Q9NPF4-183-unknown	MAKRGK...	183	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450464
Q9NPF4-200-unknown	MDVSFS...	200	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451784
Q9NPF4-200-unknown	MDVSFS...	200	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451787
Q9NPF4-313-unknown	TPLSDS...	313	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13369

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GCNVRL	268	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451787
...RGARLF	284	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450464
...RAGHRT	312	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13369
...VTWRD	335	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	312	GHRT.\|.TPLS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)