Q9NQH7: Xaa-Pro aminopeptidase 3 {ECO:0000312|HGNC:HGNC:28052}

General Information

Protein names	- Xaa-Pro aminopeptidase 3 {ECO:0000312\|HGNC:HGNC:28052} - X-Pro aminopeptidase 3 - 3.4.11.9 {ECO:0000269\|PubMed:25609706, ECO:0000269\|PubMed:28476889} - Aminopeptidase P3 - APP3
Gene names	XPNPEP3
Organism	Homo sapiens
Protease Family
Protease ID	M24.026
Chromosome location
UniProt ID	Q9NQH7

7 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Probable Xaa-Pro aminopeptidase 3 - Isoform 3 of Probable Xaa-Pro aminopeptidase 3 - Isoform 4 of Probable Xaa-Pro aminopeptidase 3 - Isoform 5 of Probable Xaa-Pro aminopeptidase 3 - Isoform 2 of Xaa-Pro aminopeptidase 3 - Isoform 3 of Xaa-Pro aminopeptidase 3 - Isoform 4 of Xaa-Pro aminopeptidase 3 - Isoform 5 of Xaa-Pro aminopeptidase 3

Sequence View

        10         20         30         40         50         60
MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP
        70         80         90        100        110        120
GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN
       130        140        150        160        170        180
FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD
       190        200        210        220        230        240
EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI
       250        260        270        280        290        300
QRLRLIKSPA EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY
       310        320        330        340        350        360
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL
       370        380        390        400        410        420
YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH
       430        440        450        460        470        480
HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV
       490        500
TQDSPLILSA DCPKEMNDIE QICSQAS         10         20         30         40         50         60
MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP
        70         80         90        100        110        120
GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN
       130        140        150        160        170        180
FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD
       190        200        210        220        230        240
EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI
       250        260        270        280        290        300
QRLRLIKSPA EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY
       310        320        330        340        350        360
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL
       370        380        390        400        410        420
YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH
       430        440        450        460        470        480
HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV
       490        500
TQDSPLILSA DCPKEMNDIE QICSQAS         10         20         30         40         50         60
MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP
        70         80         90        100        110        120
GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN
       130        140        150        160        170        180
FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD
       190        200        210        220        230        240
EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI
       250        260        270        280        290        300
QRLRLIKSPA EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY
       310        320        330        340        350        360
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL
       370        380        390        400        410        420
YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH
       430        440        450        460        470        480
HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV
       490        500
TQDSPLILSA DCPKEMNDIE QICSQAS         10         20         30         40         50         60
MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP
        70         80         90        100        110        120
GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN
       130        140        150        160        170        180
FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD
       190        200        210        220        230        240
EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI
       250        260        270        280        290        300
QRLRLIKSPA EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY
       310        320        330        340        350        360
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL
       370        380        390        400        410        420
YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH
       430        440        450        460        470        480
HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV
       490        500
TQDSPLILSA DCPKEMNDIE QICSQAS         10         20         30         40         50         60
MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP
        70         80         90        100        110        120
GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN
       130        140        150        160        170        180
FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD
       190        200        210        220        230        240
EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI
       250        260        270        280        290        300
QRLRLIKSPA EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY
       310        320        330        340        350        360
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL
       370        380        390        400        410        420
YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH
       430        440        450        460        470        480
HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV
       490        500
TQDSPLILSA DCPKEMNDIE QICSQAS         10         20         30         40         50         60
MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP
        70         80         90        100        110        120
GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN
       130        140        150        160        170        180
FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD
       190        200        210        220        230        240
EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI
       250        260        270        280        290        300
QRLRLIKSPA EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY
       310        320        330        340        350        360
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL
       370        380        390        400        410        420
YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH
       430        440        450        460        470        480
HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV
       490        500
TQDSPLILSA DCPKEMNDIE QICSQAS         10         20         30         40         50         60
MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP
        70         80         90        100        110        120
GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN
       130        140        150        160        170        180
FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD
       190        200        210        220        230        240
EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI
       250        260        270        280        290        300
QRLRLIKSPA EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY
       310        320        330        340        350        360
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL
       370        380        390        400        410        420
YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH
       430        440        450        460        470        480
HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV
       490        500
TQDSPLILSA DCPKEMNDIE QICSQAS         10         20         30         40         50         60
MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP
        70         80         90        100        110        120
GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN
       130        140        150        160        170        180
FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD
       190        200        210        220        230        240
EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI
       250        260        270        280        290        300
QRLRLIKSPA EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY
       310        320        330        340        350        360
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL
       370        380        390        400        410        420
YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH
       430        440        450        460        470        480
HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV
       490        500
TQDSPLILSA DCPKEMNDIE QICSQAS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NQH7-1-unknown	MPWLLS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NQH7-1-unknown	MPWLLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94737
Q9NQH7-1-unknown	MPWLLS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94739
Q9NQH7-24-unknown	MLCSQR...	24	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94738
Q9NQH7-24-unknown	MLCSQR...	24	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96951
Q9NQH7-24-unknown	MLCSQR...	24	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96952
Q9NQH7-32-unknown	SLQPVP...	32		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9NQH7-32-unknown	SLQPVP...	32	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160395
Q9NQH7-32-unknown	SLQPVP...	32	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160394
Q9NQH7-32-unknown	SLQPVP...	32	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160396
Q9NQH7-32-unknown	SLQPVP...	32	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NQH7-32-	SLQPVP...	32		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NQH7-80-unknown	MSLIQK...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94736
Q9NQH7-80-unknown	MSLIQK...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96805
Q9NQH7-80-unknown	MSLIQK...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96804
Q9NQH7-80-unknown	MSLIQK...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96806
Q9NQH7-126-unknown	GFQEPD...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174077
Q9NQH7-126-unknown	GFQEPD...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174075
Q9NQH7-126-unknown	GFQEPD...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174074
Q9NQH7-126-unknown	GFQEPD...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174076
Q9NQH7-126-	GFQEPD...	126		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CSQAS	507	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CSQAS	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90354
...CSQAS	507	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90356

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)