Q9NQT5: Exosome complex component RRP40

General Information

Protein names	- Exosome complex component RRP40 - Exosome component 3 - Ribosomal RNA-processing protein 40 - p10
Gene names	EXOSC3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NQT5

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEPASVAAE SLAGSRARAA RTVLGQVVLP GEELLLPEQE DAEGPGGAVE RPLSLNARAC
        70         80         90        100        110        120
SRVRVVCGPG LRRCGDRLLV TKCGRLRHKE PGSGSGGGVY WVDSQQKRYV PVKGDHVIGI
       130        140        150        160        170        180
VTAKSGDIFK VDVGGSEPAS LSYLSFEGAT KRNRPNVQVG DLIYGQFVVA NKDMEPEMVC
       190        200        210        220        230        240
IDSCGRANGM GVIGQDGLLF KVTLGLIRKL LAPDCEIIQE VGKLYPLEIV FGMNGRIWVK
       250        260        270
AKTIQQTLIL ANILEACEHM TSDQRKQIFS RLAES

Isoforms

- Isoform 2 of Exosome complex component RRP40

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NQT5-1-unknown	MAEPAS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74328
Q9NQT5-2-unknown	MAEPAS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NQT5-2-Acetylation	AEPASV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NQT5-2-Acetylation	AEPASV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NQT5-2-Acetylation	AEPASV...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9NQT5-2-Acetylation	AEPASV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NQT5-2-Acetylation	AEPASV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110490
Q9NQT5-6-unknown	SVAAES...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15019
Q9NQT5-6-unknown	SVAAES...	6		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194730

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...MAEPAS	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15019
	...RLAES	275	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	5	EPAS.\|.SVAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)